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Inflammation
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ALX-350-086 Revised 08-Apr-08
Nordihydroguaiaretic acid
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SYNONYMS NDGA
4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products for Inflammation Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-086-G001   1 g 62.00 USD Add To Cart
Product Specification
FORMULA: C18H22O4
MW: 302.4
CAS NUMBER: 500-38-9
MERCK INDEX: 14: 6693
SOURCE/HOST: Synthetic.
PURITY: ≥95%
APPEARANCE: Crystalline powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or acetone; slightly soluble in hot water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Antioxidant and antineoplastic. Lipoxygenase inhibitor. Stimulates the rapid retrograde movement of both Golgi stacks and the trans-Golgi network to the endoplasmatic reticulum (ER). Displays pleiotropic effects on cells, which include apoptosis, cell proliferation, differentiation and chemotaxis. Anticancer agent.
Product Specific Literature References
Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid: M. Pavani, et al.; Biochem. Pharmacol. 48, 1935 (1994) Abstract
Nordihydroguaiaretic acid blocks protein transport in the secretory pathway causing redistribution of Golgi proteins into the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 273, 3068 (1998) Abstract; Full Text
Effect of nordihydroguaiaretic acid on the secretion of lipoprotein lipase: S.M. Kim, et al.; J. Biochem. Mol. Biol. 35, 518 (2002) Abstract; Full Text
Mechanisms underlying the activation of large conductance Ca2+-activated K+ channels by nordihydroguaiaretic acid: H. Yamamura, et al.; Jpn. J. Pharmacol. 89, 53 (2002) Abstract
Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid: T. Fujiwara, et al.; BBRC 301, 927 (2003) Abstract
Stepwise dissection of the intracellular fate of cationic cell-penetrating peptides: R. Fischer, et al.; J. Biol. Chem. 279, 12625 (2004) Abstract; Full Text
The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling: C.A. Culver, et al.; Life Sci. 77, 2457 (2005) Abstract
Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs: E. Floriano-Sanchez, et al.; Free Radic. Res. 40, 523 (2006) Abstract
Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells: K. Arasaki, et al.; Mol. Pharmacol. 71, 454 (2007) Abstract
Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro: Y.H. Siddique, et al.; J. Environ. Biol. 28, 279 (2007) Abstract
Further Categories Containing This Product:
Golgi Apparatus • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Antitumor Reagents • Lipoxygenases/Related Products • Natural Products - Antioxidants
 
 
ALX-380-093 Revised 16-Jun-08
Novobiocin . sodium salt
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SYNONYMS Albamycin
Streptonivicin
N-[7-[[3-O-Aminocarbonyl-6-deoxy-5-C-methyl-4-O-β-L-lyxo-hexapyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)benzamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-093-G001   1 g 30.00 USD Add To Cart
Product Specification
FORMULA: C31H35N2O11 . Na
MW: 611.6 . 23.0
CAS NUMBER: 1476-53-5
MERCK INDEX: 14: 6722
RTECS: RD5425000
PURITY: ≥95%
APPEARANCE: White to pale yellow solid.
SOLUBILITY: Soluble in water (100mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. IRRITANT.

Product Description
Antibiotic. Inhibitor of HSP90. Interacts with the C-terminal ATP-binding domain of HSP90 in contrast to the benzoquinone ansamycins 17-AAG (Prod. No. ALX-380-091), geldanamycin (Prod. No. ALX-380-054), herbimycin A (Prod. No. ALX-350-029), and the chemically unrelated radicicol (Prod. No. ALX-380-092), which bind to the N-terminal ATP-binding site of HSP90. Inhibitor of DNA gyrase. Useful for the production of positively supercoiled plasma DNA, targeting the nucleotide-binding site of gyrase B. Inhibits retrovirus RNA-dependent DNA polymerase. Potent inhibitor of ADP ribosylation. Inhibits LPS-induced production of pro-inflammatory cytokines, such as TNF-α, IL-1, IL-6 and IL-10. Inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins. Reverses etoposide resistance in non-P-glycoprotein expressing multidrug resistant (MDR) tumor cell lines. Inducer of CD38 on cells of the myelomonocytic  lineage. Forms ion channels in lipid bilayers.
Product Specific Literature References
Novobiocin-a specific inhibitor of semiconservative DNA replication in permeabilized Escherichia coli cells: W.L. Staudenbauer; J. Mol. Biol. 96, 201 (1975) Abstract
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase: M. Gellert, et al.; PNAS 73, 4474 (1976) Abstract; Full Text
Energy coupling in DNA gyrase and the mechanism of action of novobiocin: A. Sugino, et al.; PNAS 75, 4838 (1978) Abstract; Full Text
Effect of novobiocin and other DNA gyrase inhibitors on virus replication and DNA synthesis in herpes simplex virus type 1-infected BHK cells: B. Francke and J. Margolin; J. Gen. Virol. 52, 401 (1981) Abstract; Full Text
Inhibition of retrovirus RNA-dependent DNA polymerase by novobiocin and nalidixic acid: Y. Sumiyoshi, et al.; J. Gen. Virol. 64, 2329 (1983) Abstract
Positively supercoiled plasmid DNA is produced by treatment of Escherichia coli with DNA gyrase inhibitors: D. Lockshon and D.R. Morris; Nucleic Acids Res. 11, 2999 (1983) Abstract
Structure-activity relationships in DNA gyrase inhibitors: S. Radl; Pharmacol. Ther. 48, 1 (1990), (Review) Abstract
Reversal of etoposide resistance in non-P-glycoprotein expressing multidrug resistant tumor cell lines by novobiocin: G. Rappa, et al.; Cancer Res. 53, 58487 (1993) Abstract
The properties of ion channels formed by the coumarin antibiotic, novobiocin, in lipid bilayers: A.M. Feigin, et al.; Biochim. Biophys. Acta 1234, 43 (1995) Abstract
Mechanism of inhibition of vaccinia DNA topoisomerase by novobiocin and coumermycin: J. Sekiguchi, et al.; J. Biol. Chem. 271, 2313 (1996) Abstract; Full Text
Immunomodulating properties of the antibiotic novobiocin in human monocytes: A. Luhrmann, et al.; Antimicrob. Agents Chemother. 42, 1911 (1998) Abstract; Full Text
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins: M.G. Marcu, et al.; J. Natl. Cancer Inst. 92, 242 (2000) Abstract
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone: M.G. Marcu, et al.; J. Biol. Chem. 275, 37181 (2000) Abstract; Full Text
Novobiocin is a novel inducer of CD38 on cells of the myelomonocytic lineage: A. Thiele, et al.; Biochim. Biophys. Acta 1542, 32 (2002) Abstract
Evidence that the novobiocin-sensitive ATP-binding site of the heat shock protein 90 (hsp90) is necessary for its autophosphorylation: T. Langer, et al.; Cell Biol. Int. 26, 653 (2002) Abstract
Alteration of Escherichia coli topoisomerase IV to novobiocin resistance: C.D. Hardy and N.R. Cozzarelli; Antimicrob. Agents Chemother. 47, 941 (2003) Abstract; Full Text
Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance: C.H. Gross, et al.; Antimicrob. Agents Chemother. 47, 1037 (2003) Abstract; Full Text
A coumermycin/novobiocin-regulated gene expression system: H.F. Zhao, et al.; Hum. Gene Ther. 14, 1619 (2003) Abstract
Destabilization of the non-pathogenic, cellular prion-protein by a small molecular drug: H.J. Ochel and G. Gademann; Antivir. Ther. 9, 441 (2004) Abstract
Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions: B.G. Yun, et al.; Biochemistry 43, 8217 (2004) Abstract
Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90: J.A. Burlison, et al.; JACS 128, 15529 (2006) Abstract
Further Categories Containing This Product:
Protein Synthesis Other Products • HSP90/HtpG/Related Products • Antibiotics - Topoisomerase Inhibitors • Anti-inflammatory Agents Other Products
 
 
ALX-270-197 Revised 15-Jan-08
NS-398
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SYNONYMS N-[2-(Cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-197-M005   5 mg 55.00 USD Add To Cart
ALX-270-197-M010   10 mg 98.00 USD Add To Cart
ALX-270-197-M050   50 mg 395.00 USD Add To Cart
Product Specification
FORMULA: C13H18N2O5S
MW: 314.4
CAS NUMBER: 123653-11-2
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white crystalline solid
SOLUBILITY: Soluble in 100% ethanol (warm; sonification), DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Potent and selective cyclooxygenase-2 (COX-2) inhibitor.
Product Specific Literature References
Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats: I. Arai, et al.; Res. Comm. Chem. Pathol. Pharmacol. 81, 259 (1993) Abstract
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions: N. Futaki, et al.; Gen. Pharmacol. 24, 105 (1993) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic: J.L. Masferrer, et al.; PNAS 91, 3228 (1994) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms: M. Ouellet & M.D. Percival; Biochem. J. 306, 247 (1995) Abstract
Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism: M.C. Zatelli, et al.; J. Clin. Endocrinol. Metab. 90, 5754 (2005) Abstract; Full Text
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-350-308 Revised 03-Apr-08
3-O-Acetyl-β-boswellic acid
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SYNONYMS AβBA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-308-M001   1 mg 45.00 USD Add To Cart
ALX-350-308-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C32H50O4
MW: 498.8
CAS NUMBER: 5968-70-7
SOURCE/HOST: Isolated from Boswellia sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone, dimethyl formamide, DMSO, dichloromethane, 100% ethanol or methanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, non-competitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-100 times more potent than natural boswellic acid.
Product Specific Literature References
Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers: V. Sterk, et al.; Planta Med. 70, 1155 (2004) Abstract
Effects of Boswellia serrata in mouse models of chemically induced colitis: P.R. Kiela, et al.; Am. J. Physiol. Gastrointest. Liver. Physiol. 288, G798 (2005) Abstract
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo: T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) Abstract; Full Text
Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid: D. Poeckel, et al.; Br. J. Pharmacol. 146, 514 (2005) Abstract
Boswellic acids: biological actions and molecular targets: D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006), Review Abstract
Further Categories Containing This Product:
Natural Products - Topoisomerase Inhibitors • NF-kB Pathway Inhibitors • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Protein Kinase Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Anti-inflammatory Agents • Antitumor Agents (Apoptosis Inducers) • Lipoxygenases/Related Products
 
 
ALX-270-105 Revised 05-Dec-04
OBAA
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SYNONYMS 3-(4-Octadecyl)-benzoylacrylic acid
4-(4-Octadecylphenyl)-4-oxobutenoic acid
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PLA2 Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-105-M005   5 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C28H44O3
MW: 428.6
CAS NUMBER: 134531-42-3
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Potent inhibitor of phospholipase A2.
Product Specific Literature References
Phospholipase A2 inhibition by alkylbenzoylacrylic acids: T. Köhler, et al.; Agents Actions 32, 70 (1991) Abstract
Allergen-induced bronchospasm in passively sensitized guinea pigs: influence of new substances in comparison to reference compounds: S. Madi, et al.; Agents Actions 32, 144 (1991) Abstract
Phospholipase A2 inhibition by alkylbenzoylacrylic acids: T. Köhler, et al.; Biochem. Pharmacol. 44, 805 (1992) Abstract
 
 
ALX-746-001 Revised 06-Oct-06
ODN 1668 (TLRgrade™) (synthetic)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Oligodeoxynucleotides [ODNs]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-746-001-T100   100 tests 155.00 USD Add To Cart
Product Specification
SEQUENCE: 5’-tccatgacgttcctgatgct-3’
(lower case letters indicate phosphorothioate linkage).
MW: 6383 (ammonium salt)
SOURCE/HOST: Synthetic.
QUANTITY: 15nmol (~96µg). Sufficient for at least 100 cellular activation assays at 0.1-0.5µg/well when performed in a 200µl assay volume (i.e. 96 well microtiter plate).
PURITY DETAIL: Activity and endotoxin tested - TLRgrade™.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 100µM stock solution, dissolve the total vial content in 150µl endotoxin-free water (included) or PBS (to order seperately).
To obtain optimal dissolving we recommend the following procedure:
- Add 50% of the solvent and let dissolve for 10 min.
- Add remaining 50% of the solvent and mix thoroughly.
- Moderate warming may aid dissolving.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Aqueous stock solution is stable for 1 day when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Protect from light.
Product Images
Please click on thumbnails to enlarge.
Product Description
CpG oligodeoxynucleotide (Type B) with phosphorothioate backbone. Specific ligand for mouse TLR9 (Toll-like receptor 9).
General Information
BACKGROUND/TECHNICAL INFORMATION

Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).

Related Products:

- PBS (endotoxin-free) (Prod. No. ALX-505-007)

- ODN 1720 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-200)

- iODN 2088 (TLRgrade™) (synthetic) (Inhibitory for mouse) (Prod. No. ALX-746-250)
Related Products
 
 
ALX-746-200 Revised 06-Oct-06
ODN 1720 (TLRgrade™) (synthetic) (Control)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Oligodeoxynucleotides [ODNs]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-746-200-T100   100 tests 155.00 USD Add To Cart
Product Specification
SEQUENCE: 5’-tccatgagcttcctgatgct-3’
(lower case letters indicate phosphorothioate linkage).
MW: 6383 (ammonium salt)
SOURCE/HOST: Synthetic.
QUANTITY: 15nmol (~96µg). Sufficient for at least 100 cellular activation assays at 0.1-0.5µg/well when performed in a 200µl assay volume (i.e. 96 well microtiter plate).
PURITY DETAIL: Activity and endotoxin tested - TLRgrade™.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02 EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 100µM stock solution, dissolve the total vial content in 150µl endotoxin-free water (included) or PBS (to order seperately).
To obtain optimal dissolving we recommend the following procedure:
- Add 50% of the solvent and let dissolve for 10 min.
- Add remaining 50% of the solvent and mix thoroughly.
- Moderate warming may aid dissolving.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Aqueous stock solution is stable for 1 day when stored at +4°C.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Protect from light. After reconstitution, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Description
GpC oligodeoxynucleotide with phosphorothioate backbone. Inactive control for ODN 1668 (Prod. No. ALX-746-001).
General Information
BACKGROUND/TECHNICAL INFORMATION

Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).

Related Products:

- PBS (endotoxin-free) (Prod. No. ALX-505-007)

- ODN 1668 (TLRgrade™) (synthetic) (Prod. No. ALX-746-001)
Related Products
 
 
ALX-746-002 Revised 06-Oct-06
ODN 1826 (TLRgrade™) (synthetic)
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SYNONYMS CpG-B (TLRgrade™) (synthetic)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Oligodeoxynucleotides [ODNs]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-746-002-T100   100 tests 155.00 USD Add To Cart
Product Specification
SEQUENCE: 5’-tccatgacgttcctgacgtt-3’
(lower case letters indicate phosphorothioate linkage).
MW: 6383 (ammonium salt)
SOURCE/HOST: Synthetic.
QUANTITY: 15nmol (~96µg). Sufficient for at least 100 cellular activation assays at 0.1-0.5µg/well when performed in a 200µl assay volume (i.e. 96 well microtiter plate).
PURITY DETAIL: Activity and endotoxin tested - TLRgrade™.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 100µM stock solution, dissolve the total vial content in 150µl endotoxin-free water (included) or PBS (to order seperately).
To obtain optimal dissolving we recommend the following procedure:
- Add 50% of the solvent and let dissolve for 10 min.
- Add remaining 50% of the solvent and mix thoroughly.
- Moderate warming may aid dissolving.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Aqueous stock solution is stable for 1 day when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Description
CpG oligodeoxynucleotide (Type B) with phosphorothioate backbone. Specific ligand for mouse TLR9 (Toll-like receptor 9). For inactive control compound see ODN 1982 (Prod. No. ALX-746-201).
General Information
BACKGROUND/TECHNICAL INFORMATION

Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).

Related Products:

- PBS (endotoxin-free) (Prod. No. ALX-505-007)

- ODN 1982 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-201)

- iODN 2088 (TLRgrade™) (synthetic) (Inhibitory for mouse) (Prod. No. ALX-746-250)
Related Products