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ALX-430-156
Revised 21-Apr-08
6BIO
SYNONYMS
(2’Z,3’E)-6-Bromoindirubin-3’-oxime
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Non-apoptotic Cell Death / Necrosis
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ALX-430-156-M001
1 mg
40.00 USD
Product Specification
FORMULA:
C
16
H
10
BrN
3
O
2
MW:
356.2
CAS NUMBER:
667463-62-9
PURITY:
≥98%
APPEARANCE:
Dark red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
Product Description
Inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β).
Product Specific Literature References
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases:
P. Polychronopoulos, et al.; J. Med. Chem.
47
, 935 (2004)
Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death:
J. Ribas, et al.; Oncogene
25
, 6304 (2006)
Abstract
Inverse in silico screening for identification of kinase inhibitor targets:
S. Zahler, et al.; Chem. Biol.
14
, 1207 (2007)
Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins:
V. Myrianthopoulos, et al.; J. Med. Chem.
50
, 4027 (2007)
Abstract
Related Products
ALX-270-271
Indirubin-3'-monoxime
ALX-430-149
7BIO
ALX-430-157
Me-7BIO
ALX-270-296
Indirubin-5-sulfonic acid . sodium salt
ALX-270-361
Indirubin
ALX-270-424
5-Iodo-indirubin-3'-monoxime
ALX-430-149
Revised 23-Jun-08
7BIO
SYNONYMS
(2’Z, 3’E)-7-Bromoindirubin-3’-monoxime
MLS2156
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Non-apoptotic Cell Death / Necrosis
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-430-149-M005
5 mg
80.00 USD
ALX-430-149-M025
25 mg
320.00 USD
Product Specification
FORMULA:
C
16
H
10
BrN
3
O
2
MW:
356.2
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
Dark brown solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
Product Description
Induces a rapid caspase-independent cell death process distinct from apoptosis. Demonstrated selective inhibition of aurora kinase B (IC
50
=4.6µM) and aurora kinase C (IC
50
=0.7µM) whereas the homologeous aurora kinase A is poorly inhibited.
Product Specific Literature References
3’-Substituted 7-halogenoindirubins, a new class of cell death inducing agents:
Y. Ferandin, et al.; J. Med. Chem.
49
, 4638 (2006)
Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death:
J. Ribas, et al.; Oncogene
25
, 6304 (2006)
Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins:
V. Myrianthopoulos, et al.; J. Med. Chem.
50
, 4027 (2007)
Abstract
7-Bromoindirubin-3’-oxime uncovers a serine protease-mediated paradigm of necrotic cell death:
J. Ribas, et al.; Biochem. Pharmacol.
76
, 39 (2008)
Abstract
Related Products
ALX-270-271
Indirubin-3'-monoxime
ALX-430-157
Me-7BIO
ALX-430-156
6BIO
ALX-270-296
Indirubin-5-sulfonic acid . sodium salt
ALX-270-361
Indirubin
ALX-270-424
5-Iodo-indirubin-3'-monoxime
ALX-630-093
Revised 23-Jul-08
Aflatoxin B1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
Ordering Information
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Format:
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ALX-630-093-M001
1 mg
28.00 USD
ALX-630-093-M005
5 mg
110.00 USD
Product Specification
FORMULA:
C
17
H
12
O
6
MW:
312.3
CAS NUMBER:
1162-65-8
MERCK INDEX:
14:
180
RTECS:
GY1925000
SOURCE/HOST:
Isolated from
Aspergillus flavus
.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to yellow powder.
SOLUBILITY:
Soluble in DMSO (20mg/ml) or methylene chloride (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
VERY TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.
Product Description
Naturally occuring mycotoxin produced by many species of
Aspergillus
. Metabolized by the liver to the reactive intermediate aflatoxin M
1
. Exposure may produce acute necrosis, cirrhosis and carcinoma of the liver. Induces DNA damage.
Product Specific Literature References
Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus:
C.P. Wild, et al.; Environ. Health Perspect.
99
, 115 (1993)
Abstract
A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China:
G.S. Qian, et al.; Cancer Epidemiol. Biomarkers Prev.
3
, 3 (1994)
Abstract
Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone:
H. Autrup, et al.; Mutagenesis
11
, 69 (1996)
Abstract
Activation and detoxication of aflatoxin B1:
F.P. Guengerich, et al.; Mutat. Res.
402
, 121 (1998), (Review)
Abstract
Hyperplasia, partial hepatectomy, and the carcinogenicity of aflatoxin B1:
B.D. Roebu; J. Cell. Biochem.
91
, 242 (2004), (Review)
Abstract
Aflatoxin B1-induced DNA damage and its repair:
L. L. Bedard & T. E. Massey; Cancer Lett.
241
, 174 (2006), (Review)
Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
•
Non-apoptotic Cell Death / Necrosis
•
Plant Research Reagents / Related Products
ALX-630-103
Revised 04-Sep-08
Aflatoxin B2
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
Ordering Information
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ALX-630-103-M001
1 mg
55.00 USD
ALX-630-103-M005
5 mg
260.00 USD
Product Specification
FORMULA:
C
17
H
14
O
6
MW:
314.3
CAS NUMBER:
7220-81-7
MERCK INDEX:
14:
180
RTECS:
GY1722000
SOURCE/HOST:
Isolated from
Aspergillus flavus.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
MAY BE CARCINOGENIC. VERY TOXIC.
Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Aflatoxin B2: Chemical Identity and Biological Activity:
S.B. Chang, et al.; Science
142
, 1191 (1963)
Abstract
Accumulation of only aflatoxin B2 by a strain of Aspergillus flavus:
H.W. Schroeder & W.W. Carlton; Appl. Microbiol.
25
, 146 (1973)
Abstract
In vitro metabolism of aflatoxin B2 by animal and human liver:
B.D. Roebuck, et al.; Cancer Res.
38
, 999 (1978)
Abstract
Interaction of aflatoxin B2 with rat liver DNA and histones in vivo:
J.D. Groopman, et al.; Carcinogenesis
2
, 1371 (1981)
Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
•
Non-apoptotic Cell Death / Necrosis
•
Plant Research Reagents / Related Products
ALX-630-104
Revised 24-Sep-08
Aflatoxin G1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
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ALX-630-104-M001
1 mg
65.00 USD
ALX-630-104-M005
5 mg
260.00 USD
Product Specification
FORMULA:
C
17
H
12
O
7
MW:
328.3
CAS NUMBER:
1165-39-5
MERCK INDEX:
14:
181
RTECS:
LV1720000
SOURCE/HOST:
Isolated from
Aspergillus flavus.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to yellow powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml), methylene chloride (5mg/ml) or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
VERY TOXIC. MAY BE CARCINOGENIC.
Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Mutagenic effect of aflatoxin G1 in comparison with B1:
M.M. el-Zawahri, et al.; J. Environ. Pathol. Toxicol. Oncol.
10
, 45 (1990)
Abstract
Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins:
G. Sabbioni & C.P. Wild; Carcinogenesis
12
, 97 (1991)
Abstract
Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro:
X.M. Sun, et al.; Biomed. Environ. Sci.
15
, 145 (2002)
Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
•
Non-apoptotic Cell Death / Necrosis
•
Plant Research Reagents / Related Products
ALX-630-106
Revised 20-Jun-08
Aflatoxin G2
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
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ALX-630-106-M001
1 mg
150.00 USD
ALX-630-106-M005
5 mg
600.00 USD
Product Specification
FORMULA:
C
17
H
14
O
7
MW:
330.3
CAS NUMBER:
7241-98-7
MERCK INDEX:
14:
181
RTECS:
LV1700000
SOURCE/HOST:
Isolated from
Aspergillus flavus.
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
MAY BE CARCINOGENIC. VERY TOXIC.
Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Combining Ability for Resistance to Field Aflatoxin Accumulation in Maize Grain:
D.P. Gorman, et al.; Plant Breeding
109
, 296 (1992)
Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential:
J.J. Wong & D.P. Hsieh; PNAS
73
, 2241 (1976)
Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Plant Research Reagents / Related Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
•
Non-apoptotic Cell Death / Necrosis
ALX-630-095
Revised 03-Apr-08
Aflatoxin M1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
Ordering Information
Product Numbers:
Format:
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ALX-630-095-MC01
0.1 mg
80.00 USD
Product Specification
FORMULA:
C
17
H
12
O
7
MW:
328.3
CAS NUMBER:
6795-23-9
MERCK INDEX:
14:
182
RTECS:
GY1880000
SOURCE/HOST:
Isolated from
Aspergillus flavus
.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methylene chloride (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
MAY BE MUTAGENIC. MAY BE CARCINOGENIC. VERY TOXIC.
Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin. Hydroxylated metabolite of aflatoxin B
1
.
Product Specific Literature References
Production and characterization of monoclonal antibodies against aflatoxin M1:
N.A. Woychik, et al.; Appl. Environ. Microbiol.
48
, 1096 (1984)
Abstract
;
Full Text
Comparative binding and sequence interaction specificities of aflatoxin B1, aflatoxicol, aflatoxin M1, and aflatoxicol M1 with purified DNA:
K. Marien, et al.; J. Biol. Chem.
262
, 7455 (1987)
Abstract
;
Full Text
Presence of aflatoxin M1 in commercial ultra-high-temperature-treated milk.:
J.L. Blanco, et al.; Appl. Environ. Microbiol.
54
, 1622 (1988)
Abstract
;
Full Text
Distribution and stability of aflatoxin M1 during processing, ripening and storage of Telemes cheese:
A. Govaris, et al.; Food Addit. Contam.
18
, 437 (2001)
Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
•
Non-apoptotic Cell Death / Necrosis
•
Plant Research Reagents / Related Products
ALX-380-002
Revised 03-Apr-08
Cyclosporin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Immunomodulators
Ordering Information
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Format:
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ALX-380-002-M100
100 mg
46.00 USD
ALX-380-002-5100
5x100 mg
190.00 USD
ALX-380-002-G001
1 g
290.00 USD
ALX-380-002-5001
5x1 g
1'150.00 USD
Product Specification
FORMULA:
C
62
H
111
N
11
O
12
MW:
1202.6
CAS NUMBER:
59865-13-3
MERCK INDEX:
14:
2752
RTECS:
GZ4120000
SOURCE/HOST:
Isolated from
Fusarium solani.
PURITY:
≥99% (Assay)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methanol, 100% ethanol, acetone or petroleum ether; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
MAY BE TERATOGENIC. TOXIC. MAY BE CARCINOGENIC.
Product Description
Antibiotic. Potent immunosuppressor. Widely used after organ transplantation. Binds to cytosolic proteins of the cyclophilin family. Cyclosporin A-cyclophilin complexes block protein phosphatase 2B (PP2B; calcineurin), a key enzyme in T cell activation. As a result of the calcineurin inhibition, cyclosporine A blocks various cellular processes such as activation of T cells and expression of several lymphokines (especially IL-2). Inhibits cytochrome c release from mitochondria. Inhibits nitric oxide (NO) synthesis.
Product Specific Literature References
Cyclosporin A and C-New metabolites from Trichodermapolysporum (Link ex Pers.) Rifai:
Dreyfuss M., et al.; Europ. J. appl. Microbiol.
3
, 125 (1976)
Immunosuppression for organ grafting - observations on cyclosporin A:
R. Y. Calne; Immunol. Rev.
46
, 113 (1976), Review
Abstract
Immunological actions of cyclosporin A in rheumatoid arthritis:
D. Yocum; Br. J. Rheumatol.
32
, 38 (1993), Review
Abstract
Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury:
A.P. Halestrap, et al; Mol. Cell. Biochem.
174
, 167 (1997), Review
Abstract
New aspects of cyclosporin a mode of action: from gene silencing to gene up-regulation:
L. Mascarell & P. Truffa-Bachi; Mini Rev. Med. Chem.
3
, 205 (2003), Review
Abstract
Rationale for T cell inhibition by cyclosporin A in major autoimmune diseases:
G.F. Ferraccioli, et al.; Ann. N. Y. Acad. Sci.
1051
, 658 (2005), Review
Abstract
Further Categories Containing This Product:
MPTP [Mitochondrial Transition Pore] / Related Products
•
Antibiotics - Nitric Oxide Pathway Modulators
•
Antibiotics - Apoptosis Inducers & Inhibitors
•
Non-apoptotic Cell Death / Necrosis
ALX-380-282
Revised 19-Mar-08
Cyclosporin C
SYNONYMS
Thr
2
-cyclosporin A
7-L-Threonine-cyclosporin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Immunomodulators
Ordering Information
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ALX-380-282-M001
1 mg
50.00 USD
ALX-380-282-M005
5 mg
200.00 USD
Product Specification
FORMULA:
C
62
H
111
N
11
O
13
MW:
1218.6
