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Inflammation
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ALX-420-038 Revised 09-May-07
R-848
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SYNONYMS 4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol
S 28463
Resiquimod
PRODUCT LINE Immunology
PRODUCT CATEGORY Immunomodulators Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-038-M005   5 mg 50.00 USD Add To Cart
ALX-420-038-M025   25 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C17H22N4O2
MW: 314.4
CAS NUMBER: 144875-48-9
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% methanol or 5% methanol in dichloromethane. Poorly soluble in acetonitrile or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Potent antitumor and antiviral compound. Stimulates antibody secretion, cytokine production, protection from apoptosis and CD80 upregulation.
Product Specific Literature References
The immune response modifier resiquimod mimics CD40-induced B cell activation: G.A. Bishop, et al.; Cell. Immunol. 208, 9 (2001) Abstract
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway: H. Hemmi, et al.; Nat. Immunol. 3, 196 (2002) Abstract
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848: M. Jurk, et al.; Nat. Immunol. 3, 499 (2002) Abstract
Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responses: J.J. Wu, et al.; Antiviral Res. 64, 79 (2004) Abstract
TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848): R.D. Weeratna, et al.; Vaccine 23, 5263 (2005) Abstract
Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells: G. Caron, et al.; J. Immunol. 175, 1551 (2005) Abstract; Full Text
Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and resiquimod (R-848): M.J. McCluskie, et al.; Antiviral Res. 69, 77 (2006) Abstract
Further Categories Containing This Product:
TLR Agonists Other Products • CD40 & CD40L [CD154]/Related Products • Inflammasome
 
 
ALX-420-039 Revised 14-Aug-08
Imiquimod
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SYNONYMS 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
R-837
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Agonists Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-039-M100   100 mg 55.00 USD Add To Cart
ALX-420-039-M250   250 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C14H16N4
MW: 240.3
CAS NUMBER: 99011-02-6
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C.

Product Description
Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.
Product Specific Literature References
Imiquimod applied topically: a novel immune response modifier and new class of drug: R.L. Miller, et al.; Int. J. Immunopharmacol. 21, 1 (1999) Abstract
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway: H. Hemmi, et al.; Nat. Immunol. 3, 196 (2002) Abstract
In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases: C. Hesling, et al.; Br. J. Dermatol. 150, 761 (2004) Abstract
Imiquimod as an antiangiogenic agent: V.W. Li, et al.; J. Drugs Dermatol. 4, 708 (2005) Abstract
Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis: S. Majewski, et al.; Int. J. Dermatol. 44, 14 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Stimulation of TLR7 can be achieved with 1-10µg/ml of the compound for 6 to 24 hours.

Related Products:
- ddWater (endotoxin-free) (Prod. No. ALX-505-008)
- PBS (endotoxin-free) (Prod. No. ALX-505-007)
Related Products
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Angiogenesis Modulators Other Products • MMPs Other Products • Inflammasome
 
 
ALX-480-021 Revised 16-Dec-04
Adenosine 5'-triphosphate . disodium salt
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SYNONYMS ATP . 2Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-021-G001   1 g 15.00 USD Add To Cart
ALX-480-021-G005   5 g 45.00 USD Add To Cart
Product Specification
FORMULA: C10H14N5O13P3. 2Na
MW: 505.2 . 46.0
CAS NUMBER: 51963-61-2
MERCK INDEX: 14: 155
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture. Keep cool and dry.

Further Categories Containing This Product:
Inflammasome
 
 
ALX-270-066 Revised 07-Apr-08
Lavendustin C
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SYNONYMS Compound 5
5-(N-2,5-Dihydroxybenzyl)aminosalicylic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-270-066-M001   1 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C14H13NO5
MW: 275.3
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Potent inhibitor of protein tyrosine kinases and Ca2+/calmodulin-dependent kinase II. Acts also as an inhibitor of EGFR tyrosine kinase and pp60c-src kinase.
Product Specific Literature References
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus: T. Onoda, et al.; J. Nat. Prod. 52, 1252 (1989) Abstract
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors: T.J. O'Dell, et al.; Nature 353, 558 (1991) Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989) Abstract
Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor: H.M. Burt, et al.; J. Leukoc. Biol. 55, 112 (1994) Abstract
Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway: D. Lidington, et al.; J. Cell Physiol. 185, 117 (2000) Abstract
Related Products
Further Categories Containing This Product:
CAM Kinase Inhibitors • Lipopolysaccharides [LPS]/Related Products • Tyrosine Kinase Inhibitors • EGFR Kinase Inhibitors
 
 
ALX-350-227 Revised 28-Apr-08
Myristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-227-M100   100 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C11H12O3
MW: 192.2
CAS NUMBER: 607-91-0
MERCK INDEX: 14: 6334
SOURCE/HOST: Isolated from Petroselinium hortense Hoffmann.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless to slightly yellow liquid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Natural product isolated from parsley oil. Inducer of glutathione S-transferases. Also inhibits chemical carcinogenesis. Induces rat and human cytochrome P450 enzymes. Has very potent hepatoprotective activity. Induces apoptosis.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.-Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Induction of rat hepatic cytochrome P450 enzymes by myristicin: H.G. Jeong & C.H. Yun; BBRC 217, 966 (1995) Abstract
Toxicological evaluation of myristicin: H. Hallstrom & A. Thuvander; Nat. Toxins 5, 186 (1997), Review Abstract
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin: C.H. Yun, et al.; Toxicol. Lett. 137, 143 (2003) Abstract
Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/ d-galactosamine-induced liver injury: T. Morita, et al.; J. Agric. Food Chem. 51, 1560 (2003) Abstract
Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells: B.K. Lee, et al.; Toxicol. Lett. 157, 49 (2005) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Lipopolysaccharides [LPS]/Related Products • Glutathione S-Transferase • Cytochrome P450 [CYP450]/Related Products • Active Substances from Fruit and Vegetables • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-581-001 Revised 03-Apr-07
LPS from E. coli, Serotype O55:B5 - Replaced by Prod. No. ALX-581-013
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
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not sold in USA
Related Products
 
 
ALX-581-002 Revised 14-Feb-07
LPS from E. coli, Serotype O111:B4 - Replaced by Prod. No. ALX-581-012
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
Ordering Information
not sold in USA
Related Products
 
 
ALX-581-004 Revised 14-Feb-07
LPS from Salmonella typhimurium - Replaced by Prod. No. ALX-581-011
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
Ordering Information
not sold in USA
Related Products
 
 
ALX-581-007 Revised 26-Apr-07
LPS from E. coli, Serotype R515 (Re) (TLRgrade™) (liquid)
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SYNONYMS Lipopolysaccharide from E. coli, Serotype R515 (Re) (TLRgrade™) (liquid)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-007-L002   2 ml 155.00 USD Add To Cart
Product Specification
SOURCE/HOST: Rough (R)-form LPS isolated and purified from E. coli R515 (Re mutant) by a modification of the PCP extraction method [1,2], converted to the uniform sodium salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Strong activator of Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Keep sterile. Use must be restricted to qualified personnel. Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream.
HAZARD: HARMFUL. HIGHLY PYROGENIC.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides : C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides  : C. Galanos & O. Luderitz; Meth. Carbohydrate. Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells: M. Huber, et al.; Eur. J. Immunol. 36, 701 (2006) Abstract
[5] The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies: N. Satta, et al.; Blood 109, 1507 (2007) Abstract
 
 
ALX-581-008 Revised 26-Apr-07
LPS from Salmonella minnesota R595 (Re) (TLRgrade™) (liquid)
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SYNONYMS Lipopolysaccharide from Salmonella minnesota R595 (Re) (TLRgrade™) (liquid)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-008-L002   2 ml 155.00 USD Add To Cart
Product Specification
RTECS: UX2990000
SOURCE/HOST: Rough (R)-form LPS, isolated and purified from Salmonella minnesota R595 (Re mutant) by a modification of the PCP extraction method [1,2], converted to the uniform sodium salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Strong activator of Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Use must be restricted to qualified personnel. Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream. Keep sterile.
HAZARD: HIGHLY PYROGENIC. HARMFUL.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Methods in Carbohydrate Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4: C. Termeer, et al.; J. Exp. Med. 195, 99 (2002) Abstract; Full Text
[5] CD36 is a sensor of diacylglycerides: K. Hoebe, et al.; Nature 433, 523 (2005) Abstract
[6] CD14 is required for MyD88-independent LPS signaling: Z. Jiang, et al.; Nat. Immunol. 6, 565 (2005 6, 565 (2005) Abstract
[7] Toll-like receptor 9-induced type I IFN protects mice from experimental colitis: K. Katakura, et al.; J. Clin. Invest. 115, 695 (2005) Abstract; Full Text
[8] R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells: M. Huber, et al.; Eur. J. Immunol. 36, 701 (2006) Abstract
 
 
ALX-581-009 Revised 14-Feb-08
LPS from Salmonella abortus equi S-form (TLRgrade™) (liquid)
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SYNONYMS Lipopolysaccharide from Salmonella abortus equi S-form (TLRgrade™) (liquid)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-009-L002   2 ml 155.00 USD Add To Cart
Product Specification
SOURCE/HOST: Smooth (S)-form LPS, isolated and purified from Salmonella abortus equi by modification of the phenol water extraction and PCP method [1,2], converted to the uniform salt form [3] and dissolved in pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Strong activator of Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Use must be restricted to qualified personnel. Keep sterile. Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream.
HAZARD: HARMFUL. HIGHLY PYROGENIC.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides  : C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969)