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Caspase Inhibitors
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ALX-850-236 Revised 29-May-08
Caspase Inhibitor Set
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Kits & Sets
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-236-KI01   1 Set 273.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: Contains 25µl (2mM) each of the following inhibitors:
  - Caspase-1 Inhibitor, Z-YVAD-FMK, yellow cap
  - Caspase-3 Inhibitor, Z-DEVD-FMK, red cap
  - Caspase-6 Inhibitor, Z-VEID-FMK, violet cap
  - Caspase-8 Inhibitor, Z-IETD-FMK, green cap
  - Caspase-Family Inhibitor, Z-VAD-FMK, amber cap
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptides that irreversibly inhibit the activity of each of the caspase-family proteases. YVAD is the recognition sequence for caspase-1/ICE, DEVD is the recognition sequence for caspase-3/CPP32, VEID is the recognition sequence for caspase-6/Mch2, IETD is the recognition sequence for caspase-8/ FLICE, and VAD is the recognition sequence for a caspase(s) that functions upstream of most other caspases.   
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend using 1000x dilutions for inhibiting caspase activity in Jurkat cell culture (e.g., add 1µl to 1ml of culture medium). Optimal doses may vary for different cells and culture conditions and must be determined individually.
MANUFACTURER Manufactured by BioVision.
Further Categories Containing This Product:
Caspase Inhibitors • Panels / Sets
 
 
ALX-850-227 Revised 29-May-08
Caspase Inhibitor Set III
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Kits & Sets
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-227-KI01   1 Set 441.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: Contains 25µl (2mM) each of the following inhibitors:
  - Caspase-1 Inhibitor, Z-YVAD-FMK, yellow cap
  - Caspase-2 Inhibitor, Z-VDVAD-FMK, orange cap
  - Caspase-3 Inhibitor, Z-DEVD-FMK, red cap
  - Caspase-5 Inhibitor, Z-WEHD-FMK, clear cap
  - Caspase-6 Inhibitor, Z-VEID-FMK, violet cap
  - Caspase-8 Inhibitor, Z-IETD-FMK, green cap
  - Caspase-9 Inhibitor, Z-LEHD-FMK, blue cap
  - Caspase-Family Inhibitor, Z-VAD-FMK, amber cap
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptides that irreversibly inhibit the activity of each of the caspase-family proteases. YVAD is the recognition sequence for caspase-1/ICE, VDVAD is the recognition sequence for caspase-2, DEVD is the recognition sequence for caspase-3/CPP32, WEHD is the recognition sequence for caspase-5, VEID is the recognition sequence for caspase-6/Mch2, IETD is the recognition sequence for caspase-8/FLICE, LEHD is the recognition sequence for caspase-9, and VAD is the recognition sequence for a caspase(s) that functions upstream of most other caspases.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend using 1’000x dilutions for inhibiting caspase activity in Jurkat cell culture (e.g. add 1µl to 1ml of culture medium). Optimal doses may vary for different cells and culture conditions and must be determined individually.
MANUFACTURER Manufactured by BioVision.
Further Categories Containing This Product:
Caspase Inhibitors • Panels / Sets
 
 
ALX-850-239 Revised 29-May-08
Caspase Inhibitor Set lV
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Kits & Sets
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-239-KI01   1 Set 679.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: Contains 25µl (2mM) each of the following inhibitors:
  - Caspase-1 Inhibitor, Z-YVAD-FMK, yellow cap
  - Caspase-2 Inhibitor, Z-VDVAD-FMK, orange cap
  - Caspase-3 Inhibitor, Z-DEVD-FMK, red cap
  - Caspase-4 Inhibitor, Z-LEVD-FMK, orange cap
  - Caspase-5 Inhibitor, Z-WEHD-FMK, clear cap
  - Caspase-6 Inhibitor, Z-VEID-FMK, violet cap
  - Caspase-8 Inhibitor, Z-IETD-FMK, green cap
  - Caspase-9 Inhibitor, Z-LEHD-FMK, blue cap
  - Caspase-10 Inhibitor, Z-AEVD-FMK, amber cap
  - Caspase-13 Inhibitor, Z-LEED-FMK, yellow cap
  - Caspase-Family Inhibitor, Z-VAD-FMK, amber cap
  - FMK Negative Control, Z-FA-FMK, clear cap
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description

Potent, cell permeable synthetic peptides that irreversibly inhibit activities of each of the caspase-family proteases. YVAD, VDVAD, DEVD, LEVD, WEHD, VEID, IETD, LEHD, and AEVD are the recognition sequences for caspase-1, -2, -3, -4, -5, -6, -8, -9, and -10. VAD is a general caspase inhibitor that inhibits all known caspases. Z-FA-FMK is a negative control for FMK inhibitors.

General Information
BACKGROUND/TECHNICAL INFORMATION We recommend using 1’000x dilutions for inhibiting caspase activity in Jurkat cell culture (e.g. add 1µl to 1ml of culture medium). Optimal doses may vary for different cells and culture conditions and must be determined individually
MANUFACTURER Manufactured by BioVision.
Related Products
Further Categories Containing This Product:
Caspase Inhibitors • Panels / Sets
 
 
ALX-850-237 Revised 07-Aug-08
Caspase Inhibitor Set Plus
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Kits & Sets
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-237-KI01   1 Set 385.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: Contains 25μl (2mM) each of the following inhibitors:
- Caspase-1 Inhibitor, Z-YVAD-FMK, yellow cap
- Caspase-2 Inhibitor, Z-VDVAD-FMK, orange cap
- Caspase-3 Inhibitor, Z-DEVD-FMK, red cap
- Caspase-6 Inhibitor, Z-VEID-FMK, violet cap
- Caspase-8 Inhibitor, Z-IETD-FMK, green cap
- Caspase-9 Inhibitor, Z-LEHD-FMK, blue cap
- Caspase-Family Inhibitor, Z-VAD-FMK, amber cap
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptide inhibitors that irreversibly inhibit the activity of each of the caspase-family proteases. YVAD is the recognition sequence for caspase-1, VDVAD is the recognition sequence for caspase-2, DEVD is the recognition sequence for caspase-3, VEID is the recognition sequence for caspase-6, IETD is the recognition sequence for caspase-8, LEHD is the recognition sequence for caspase-9, and VAD is the recognition sequence for a caspase(s) that functions upstream of most other caspases.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend using 1’000x dilutions for inhibiting caspase activity in Jurkat cell culture (e.g., Add 1µl to 1ml of culture medium). Optimal doses may vary for different cells and culture conditions and must be determined individually.
MANUFACTURER Manufactured by BioVision.
Further Categories Containing This Product:
Caspase Inhibitors • Panels / Sets
 
 
ALX-151-031 Revised 23-Nov-06
Caspase-3 Control Peptide
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-031-M001   1 mg 35.00 USD Add To Cart
ALX-151-031-M005   5 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Asp-Glu-Val-Asp-OH
FORMULA: C20H30N4O12
MW: 518.5
PURITY: ≥97%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-420-036 Revised 21-Jul-05
DICA
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SYNONYMS 2-(2,4-Dichlorophenoxy)-N-(2-mercaptoethyl)acetamide
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-420-036-M005   5 mg 40.00 USD Add To Cart
ALX-420-036-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C10H11Cl2NO2S
MW: 280.2
CAS NUMBER: 613665-26-2
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Do not store DMSO solutions for more than 1 day.
HANDLING: Keep under inert gas. Protect from oxygen.

Product Description
Inhibitor of caspase-3 and caspase-7 binding to an allosteric site and not to the active site.
Product Specific Literature References
Discovery of an allosteric site in the caspases: J.A. Hardy, et al.; PNAS 101, 12461 (2004) Abstract; Full Text
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-270-374 Revised 08-Dec-04
5-[(S)-(-)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
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SYNONYMS Caspase-7 Inhibitor
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-270-374-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C14H16N2O5S
MW: 324.4
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or methanol.
HANDLING: Packaged under inert gas. Protect from light.

Product Description
Potent, reversible, non-peptide inhibitor of caspase-3 (Ki=60nm), caspase-7 (Ki=170nM) and caspase-9 (Ki=3.1µM).
Product Specific Literature References
Potent and selective nonpeptide inhibitors of caspases 3 and 7: D. Lee, et al.; J. Med. Chem. 44, 2015 (2001) Abstract
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality: D. Lee, et al.; J. Biol. Chem. 275, 16007 (2000) Abstract
 
 
ALX-260-159 Revised 03-Jun-08
Q-VD-OPH
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SYNONYMS Pan-Caspase Inhibitor (Fluoromethylketone)
N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-260-159-M003   3 mg 840.00 USD Add To Cart
Product Specification
FORMULA: C26H25F2N3O6
MW: 513.8
PURITY: ≥90% (HPLC)
SOLUBILITY: Soluble in DMSO (10mM).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Hygroscopic. Keep under inert gas.
Product Description
Selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Protects neurotoxin-insulted neurons from apoptotic death. Displays minimal in vivo toxicity. To reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated.
Product Specific Literature References
Caspase inhibition switches doxorubicin-induced apoptosis to senescence: A. Rebbaa, et al.; Oncogene 22, 2805 (2003) Abstract
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis 8, 345 (2003) Abstract
Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia: K. Patil & S.C. Sharma; Neuroreport 15, 981 (2004) Abstract
 
 
ALX-260-153 Revised 07-Nov-05
Z-AAD-CMK (Ready-to-Use)
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SYNONYMS Granzyme B Inhibitor (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-153-R020 10mM 20 µl 175.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Ala-Ala-Asp-chloromethylketone
MW: 441.9
CONCENTRATION: 10mM
PURITY: ≥96% (HPLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptide that irreversibly inhibits granzyme B activity. The inhibitor is desigend as a methyl ester to facilitate cell permeability.
Further Categories Containing This Product:
Granzyme Inhibitors
 
 
ALX-260-146 Revised 01-Sep-05
Z-AEVD-FMK (Ready-to-Use)
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SYNONYMS Caspase-10 Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-260-146-R100 2mM 100 µl 161.00 USD Add To Cart
ALX-260-146-R020 10mM 20 µl 161.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Ala-Glu-Val-Asp-fluoromethylketone
MW: 610.0
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Irreversible, cell permeable inhibitor of caspase-10. Also inhibits caspase-6 and caspase-8. FMK inhibitors are non-toxic, and can be used in both in vivo and in vitro studies.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
General Literature References
Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998) Abstract; Full Text
 
 
ALX-260-029 Revised 22-Jul-08
Z-Asp-2,6-dichlorobenzoyloxymethylketone
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SYNONYMS Caspase Family Inhibitor
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-029-M010   10 mg 80.00 USD Add To Cart
ALX-260-029-M050   50 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C20H17Cl2NO7
MW: 454.3
CAS NUMBER: 153088-73-4
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING: Keep cool and dry.

Product Description

Irreversible, cell permeable broad-spectrum caspase inhibitor.
Product Specific Literature References
P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta- converting enzyme: R.E. Dolle, et al.; J. Med. Chem. 37, 563 (1994) Abstract
Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells: T. Mashima, et al.; BBRC 209, 907 (1995) Abstract
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer 86, 208 (2000) Abstract
Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest: C. Gajate, et al.; Cancer Res. 60, 2651 (2000) Abstract; Full Text
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension: L. Taraseviciene-Stewart; FASEB J. 15, 427 (2001) Abstract; Full Text
Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction: Y. Chandrashekhar, et al.; J. Am. Coll. Cardiol. 43, 295 (2004) Abstract
 
 
ALX-260-141 Revised 05-Jun-08
Z-DEVD-FMK (Ready-to-Use)
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SYNONYMS Caspase-3 Inhibitor (Fluoromethylketone) (Ready-to-Use)
Caspase-7 Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors