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ALX-202-030
Revised 26-May-08
COX-1 (sheep)
SYNONYMS
Cyclooxygenase 1 (sheep)
Prostaglandin H Synthase 1 (sheep)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-202-030-UT50
5 KU
259.00 USD
Product Specification
MW:
~70kDa.
EC:
1.14.99.1
SOURCE/HOST:
Isolated from sheep seminal vesicles.
CONCENTRATION:
PURITY:
≥95%
FORMULATION:
Liquid. In 80mM TRIS/HCl, pH 8.0, containing 0.1% Tween 20 and 300µM DDC.
ACTIVITY:
~20'
000U/ml.
SPECIFIC ACTIVITY:
≥45,000U/mg protein. One unit is defined as the amount of enzyme that consumes 1nmol oxygen per min. at 37°C in 0.1M TRIS/HCl, pH 8.0, containing 100µM arachidonate, 5mM EDTA, 2mM phenol and 1µM hematin.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Enzyme is extremely unstable in the absence of preservative and should be used within 1 hour.
Product Specific Literature References
Prostaglandin H synthase
:
L.J. Marnett & K.R. Maddipati; 'Peroxidases in Biology, vol 1' (J. Everse, et al. eds.), CRC Press, Inc., Boca Raton 293 (1991)
Prostaglandin endoperoxide synthase: structure and catalysis:
W.L. Smith & L.J. Marnett; Biochim. Biophys. Acta
1083
, 1 (1991)
Abstract
Prostaglandin endoperoxide synthase: regulation of enzyme expression:
D.L. DeWitt; Biochim. Biophys. Acta
1083
, 121 (1991)
Abstract
Mitogen-Inducible Prostaglandin G/H Synthase: A New Target for Nonsteroidal Antiinflammatory Drugs:
W. Xie, et al.; Drug Development Research
25
, 249 (1992)
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P05979:
COX-1 (sheep) (precursor)
AfCS Signalling Gateway link A000738:
COX-1 (mouse)
Further Categories Containing This Product:
Enzymes
•
Natural Proteins
ALX-202-032
Revised 24-Apr-06
COX-2 (sheep)
SYNONYMS
Cyclooxygenase 2 (sheep)
Prostaglandin H Synthase 2 (sheep)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-202-032-UT10
1 KU
176.00 USD
Product Specification
MW:
~72kDa/subunit.
EC:
1.14.99.1
SOURCE/HOST:
Isolated from sheep placenta.
CONCENTRATION:
PURITY:
~70%
FORMULATION:
Liquid. In 80mM TRIS-HCl, pH 8.0 with 0.1% Tween 20 and 300µM DDC.
ACTIVITY:
~4'000U/ml
SPECIFIC ACTIVITY:
~4'500U/mg protein. One unit is defined as the amount of enzyme that consumes 1nmol oxygen per min. at 37°C in 0.1M TRIS/HCl, pH 8.0, containing 100µM arachidonate, 5mM EDTA, 2mM phenol and 1µM hematin.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Enzyme is extremely unstable after removal of preservative and should be used within 1 hour.
HANDLING:
Keep stock on ice while handling. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s):
J.H. Capdevila, et al.; Biochemistry
34
, 3325 (1995)
Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons:
J.L. Johnson, et al.; Arch. Biochem. Biophys.
324
, 26 (1995)
Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro:
N. Futaki, et al.; Prostaglandins
47
, 55 (1994)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P79208:
COX-2 (sheep) (precursor)
AfCS Signalling Gateway link A000739:
COX-2 (mouse)
Further Categories Containing This Product:
Enzymes
•
Natural Proteins
ALX-210-709
Revised 03-Mar-05
Polyclonal Antibody to COX
SYNONYMS
anti-Cyclooxygenase PAb
anti-Prostaglandin H Synthase PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-709-1
1 Vial
233.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
QUANTITY:
Sufficient for 10 immunoblots.
FORMULATION:
Lyophilized IgG fraction from rabbit antiserum.
IMMUNOGEN:
Purified sheep seminal vesicle COX-1 (cyclooxygenase 1) [1].
SPECIFICITY:
Recognizes mouse, rat and sheep COX-1 and COX-2.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Specific Literature References
[1]
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
:
D.L. DeWitt & W.L. Smith; PNAS
85
, 1412 (1988)
Abstract
[2]
Immunocytochemical localization of cyclooxygenase in the rat lens
:
D.R. Zheng, et al.; Invest. Ophthalmol. Vis. Sci.
33
, 178 (1992)
Abstract
[3]
Eicosanoid metabolism in cholesterol-enriched arterial smooth muscle cells. Evidence for reduced posttranscriptional processing of cyclooxygenase I and reduced cyclooxygenase II gene expression
:
K.B. Pomerantz, et al.; Biochemistry
32
, 13624 (1993)
Abstract
[4]
Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2
:
V. Zhang, et al.; BBRC
227
, 499 (1996)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-710
Revised 10-Jul-08
Polyclonal Antibody to COX-1
SYNONYMS
anti-Cyclooxygenase 1 PAb
anti-Prostaglandin H Synthase 1 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-710-1
1 Vial
313.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Sheep
Pig
Others
SOURCE/HOST:
From rabbit.
QUANTITY:
200μg lyophilized antiserum
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with 200µl distilled water.
IMMUNOGEN:
Synthetic peptide corresponding to aa 272-282 (L
272
MHYPRGIPPQ
282
) [1,2] of sheep seminal vesicle COX-1 (cyclooxygenase 1).
SPECIFICITY:
Recognizes human, sheep and bovine endothelial COX-1. Also recognizes pig COX-1. Does not cross-react with mouse or rat COX-1 or human, mouse or sheep COX-2.
APPLICATION:
Immunocytochemistry
Immunohistochemistry
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
[1]
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
:
D.L. DeWitt & W.L. Smith; PNAS
85
, 1412 (1988)
Abstract
[2]
The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum
:
J.C. Otto & W.L. Smith; J. Biol. Chem.
269
, 19868 (1994)
Abstract
;
Full Text
[3]
Expression of prostaglandin endoperoxide H synthase 1 and 2 in human placenta at term
:
L. Macchia, et al.; BBRC
233
, 496 (1997)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-711
Revised 06-Jan-06
Polyclonal Antibody to COX-2
SYNONYMS
anti-Cyclooxygenase 2 PAb
anti-Prostaglandin H Synthase 2 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-711-1
1 Vial
189.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Monkey
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized from ~50µl purified antiserum.
RECONSTITUTION:
Reconstitute with 100µl distilled water containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 584-598 (S
584
HSRLDDINPTVLIK
598
) of mouse COX-2 (cyclooxygenase 2).
SPECIFICITY:
Recognizes human, mouse, rat, monkey, sheep and guinea pig COX-2. Does not cross-react with COX-1.
APPLICATION:
Immunohistochemistry
(frozen sections, paraffin sections;
suggested starting dilution 1:300 -1:600)
Western Blot
(1:1'000).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 years after receipt when stored at -20°C. After reconstitution store at +4°C.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-063
.
Related Products
ALX-153-063
Blocking Peptide for PAb to COX-2 (mouse) (Prod. No.
ALX-210-711
and
ALX-210-726
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-712
Revised 17-Apr-08
Polyclonal Antibody to COX-2
SYNONYMS
anti-Cyclooxygenase 2 PAb
anti-Prostaglandin H Synthase 2 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-712-1
1 Vial
269.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
FORMULATION:
Liquid. In 500µl TBS, pH 8.0, containing 50% glycerol and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 567-599 (S
567
VPDPELIKTV
TINASSSRSGLDDINPTVLLKE
599
) of human COX-2 (cyclooxygenase 2).
SPECIFICITY:
Recognizes human, mouse, rat, sheep and guinea pig COX-2. Does not cross-react with COX-1.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (frozen sections (1:300), paraffin sections (1:300))
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-726
Revised 19-Jun-06
Polyclonal Antibody to COX-2
SYNONYMS
anti-Cyclooxygenase 2 PAb
anti-Prostaglandin H Synthase 2 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-726-1
1 Vial
261.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Monkey
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
PURITY DETAIL:
Purified using a DEAE-Cibicron Blue column; some contaminating transferrin may be present but will not affect the experiment.
FORMULATION:
Liquid. In TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to C-terminal aa 570-598 (D
570
PQPTKTATINASASHSRLDDINPTVLIK
598
) of mouse and rat COX-2 (cyclooxygenase 2).
SPECIFICITY:
Recognizes human, mouse, rat, sheep, rabbit, monkey and guinea pig COX-2. Does not cross-react with COX-1.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (frozen sections or paraffin sections)
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years when stored at -20°C.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-063
.
Product Specific Literature References
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction:
R.C. Harris, et al.; J. Clin. Invest.
94
, 2504 (1994)
Abstract
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse:
S.G. Morham, et al.; Cell
83
, 473 (1995)
Abstract
Related Products
ALX-153-063
Blocking Peptide for PAb to COX-2 (mouse) (Prod. No.
ALX-210-711
and
ALX-210-726
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-750
Revised 29-Jan-08
Polyclonal Antibody to COX-1
SYNONYMS
anti-Cyclooxygenase 1 PAb
anti-Prostaglandin H Synthase 1 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
COX Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-750-1
1 Vial
313.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
PURITY DETAIL:
Affinity purified IgG.
FORMULATION:
Liquid. In TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 274-288 (L
274
MRYPPGVPPERQMA
288
) of mouse COX-1 (cyclooxygenase-1).
SPECIFICITY:
Recognizes mouse and rat COX-1. Does not cross-react with human or sheep COX-1 or with COX-2. Detects a band of ~70kDa by Western blot.
APPLICATION:
Immunohistochemistry
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year when stored at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-270-086
Revised 07-May-08
Indomethacin
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-086-G005
5 g
30.00 USD
ALX-270-086-G025
25 g
80.00 USD
Product Specification
FORMULA:
C
19
H
16
ClNO
4
MW:
357.8
CAS NUMBER:
53-86-1
MERCK INDEX:
14:
4968
PURITY:
≥98%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in acetone or methanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
VERY TOXIC.
Product Description
Non-steroidal anti-inflammatory and analgesic agent. Inhibits prostaglandin synthesis. Far more potent for inhibition of cyclooxygenases (COX) than for inhibition of lipoxygenases.
Product Specific Literature References
Chemical and biological studies on indomethacin, sulindac and their analogs:
T.Y. Shen, et al.; Adv. Drug Res.
12
, 90 (1977)
Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets:
H. Salari, et al.; Prostagl. Leukotr. Med.
13
, 53 (1984)
Abstract
Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production:
K.M. Stevenson & E.R. Lumbers; J. Dev. Physiol.
17
, 257 (1992)
Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro:
N. Futaki, et al.; Prostaglandins
47
, 55 (1994)
Abstract
Further Categories Containing This Product:
Analgesic/Anti-nociceptive Agents/Related Products
•
COX Inhibitors
ALX-270-097
Revised 07-Sep-06
Ebselen
SYNONYMS
2-Phenyl-1,2-benzisoselenazol-3-(2
H
)-one
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Peroxynitrite/Scavengers/Detection
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-097-M001
1 mg
12.00 USD
ALX-270-097-M005
5 mg
20.00 USD
ALX-270-097-M025
25 mg
60.00 USD
Product Specification
FORMULA:
C
13
H
9
NOSe
MW:
274.2
CAS NUMBER:
60940-34-3
PURITY:
≥98% (NMR)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL).
Product Specific Literature References
A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages
:
M.J. Parnham & S. Kindt; Biochem. Pharmacol.
33
, 3247 (1984)
Abstract
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions
:
M.J. Parnham & E. Graf; Biochem. Pharmacol.
36
, 3095 (1987)
Abstract
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51)
:
M. Maiorino, et al.; Biochem. Pharmacol.
37
, 2267 (1988)
Abstract
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?:
I.A. Cotgreave, et al.; Biochem. Pharmacol.
38
, 649 (1989)
Abstract
T. Nikawa, et al.; Biochem. Pharmacol.
47
, 1007 (1994)
Abstract
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals:
N. Noguchi, et al.; Biochim. Biophys. Acta
1213
, 176 (1994)
Abstract
Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione:
C. Schewe, et al.; Biochem. Pharmacol.
48
, 65 (1994)
Abstract
Ebselen: a glutathione peroxidase mimic
:
H. Sies; Meth. Enzymol.
234
, 476 (1994)
Abstract
Molecular actions of ebselen-an antiinflammatory antioxidant
:
T. Schewe; Gen. Pharmacol.
26
, 1153 (1995)
Abstract
Ebselen
:
H. Sies; Meth. Enzymol.
252
, 341 (1995)
Abstract
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite
:
H. Sies & H. Masumoto; Adv. Pharmacol.
38
, 229 (1997)
Abstract
Free radical generation by selenium compounds and their prooxidant toxicity
:
J.E. Spallholz; Biomed. Environ. Sci.
10
, 260 (1997)
Abstract
Protection against peroxynitrite by selenoproteins
:
H. Sies, et al.; Z. Naturforsch. [C]
53
, 228 (1998)
Abstract
Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury
:
G. Tiegs, et al.; J. Pharmacol. Exp. Ther.
287
, 1098 (1998)
Abstract
;
Full Text
Further Categories Containing This Product:
PKC Inhibitors
•
Malaria/Related Products
•
Lipoxygenases/Related Products
•
COX Inhibitors
•
Anti-inflammatory Agents Other Products
•
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
ALX-270-102
Revised 10-Aug-07
Naproxen
