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ALX-210-917 Revised 02-Nov-06
Polyclonal Antibody to SET (human)
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SYNONYMS anti-PHAPII (human) PAb
anti-I2αPP2A (human) PAb
anti-Phosphatase 2A Inhibitor Protein 2α (human) PAb
anti-HLA-DR-associated Protein 2 (human) PAb
anti-IGAAD (human) PAb
anti-Inhibitor of Granzyme-activated DNase (human) PAb
anti-TAF-Iβ (human) PAb
anti-Template-activating Factor Iβ (human) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2A / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-917-C050   50 µg 194.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A affinity-purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 3-16 (A3PAAKVSKKELNSN16) of human SETβ.
SPECIFICITY: Recognizes human SETβ. Detects endogenous protein by IP and WB.
APPLICATION: Flow cytometry (1:100-1:200);
Immunocytochemistry;
Immunoprecipitation;
Western blot (1:1'000).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt if stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks: P.J. Beresford, et al.; J. Biol. Chem. 276, 43285 (2001) Abstract; Full Text
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A: Z. Fan, et al.; Mol. Cell. Biol. 22, 2810 (2002) Abstract; Full Text
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A: Z. Fan, et al.; Nat. Immunol. 4, 145 (2003) Abstract
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor: Z. Fan, et al.; Cell 112, 659 (2003) Abstract
Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis: D. Martinvalet, et al.; Immunity 22, 355 (2005) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Granzymes Other Products • Polyclonal Antibodies
 
 
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