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Caspase Antibodies
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ALX-804-530 Revised 14-Aug-07
Monoclonal Antibody to Caspase-1 (mouse) (1H11)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-530-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 1H11
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Protein G sepharose purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: p20 fragment of mouse caspase-1 and synthetic peptide corresponding to aa 206-220 (T206ALEMVKEVKEFAAC220) of mouse caspase-1.
SPECIFICITY: Recognizes an epitope within the p20 fragment of mouse caspase-1. Detects a band of ~45kDa by Western blot. Does not cross-react with mouse caspase-11 or -12.
APPLICATION: ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006) Abstract; Full Text
General Information
Capases are a highly conserved family of cysteine proteases and are synthesized as inactive zymogens, which are cleaved at Asp-x sites during apoptosis, generating large and small subunits that heterodimerize to form the active enzyme. Caspase-1 is a member of the ICE/CED-3 family of caspases and is detected in the pro-form as a protein of 45 kDa.
Caspase-1 generates the bioactive form of the pro-inflammatory cytokine IL-1β from its biologically inactive precursor. Overexpression of caspase-1 in cells induces apoptosis, which can be inhibited by cytokine response modifier A (CrmA). Caspase-1 mRNA is predominantly expressed in the spleen and lung and to a lesser extent in skeletal muscle, kidney, testis and heart and within these tissues macrophages preferentially express caspase-1. Caspase-1 deficient mice have no gross abnormalities, however, macrophages from caspase-1-deficient mice are defective in IL-β processing and release.
General Literature References
Rapid hybridoma screening method for the identification of monoclonal antibodies to low-abundance cytoplasmic proteins: L.A. O'Reilly, et al.; Biotechniques 25, 824 (1998), Methodology Abstract
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9: L.A. O'Reilly, et al.; Cell Death Differ. 9, 832 (2002), Methodology Abstract
Further Categories Containing This Product:
Inflammasome • Monoclonal Antibodies
 
 
ALX-804-531 Revised 10-Mar-06
Monoclonal Antibody to Caspase-1 (mouse) (4G8)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-531-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 4G8
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Protein G sepharose purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: p20 fragment of mouse caspase-1 and synthetic peptide corresponding to aa 206-220 (T206ALEMVKEVKEFAAC220) of mouse caspase-1.
SPECIFICITY: Recognizes an epitope within the p20 fragment of mouse caspase-1. Detects a band of ~45kDa by Western blot. Does not cross-react with mouse caspase-11 or -12.
APPLICATION: ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Images
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General Information
Capases are a highly conserved family of cysteine proteases and are synthesized as inactive zymogens, which are cleaved at Asp-x sites during apoptosis, generating large and small subunits that heterodimerize to form the active enzyme. Caspase-1 is a member of the ICE/CED-3 family of caspases and is detected in the pro-form as a protein of 45 kDa.
Caspase-1 generates the bioactive form of the pro-inflammatory cytokine IL-1β from its biologically inactive precursor. Overexpression of caspase-1 in cells induces apoptosis, which can be inhibited by cytokine response modifier A (CrmA). Caspase-1 mRNA is predominantly expressed in the spleen and lung and to a lesser extent in skeletal muscle, kidney, testis and heart and within these tissues macrophages preferentially express caspase-1. Caspase-1 deficient mice have no gross abnormalities, however, macrophages from caspase-1-deficient mice are defective in IL-β processing and release.
General Literature References
Rapid hybridoma screening method for the identification of monoclonal antibodies to low-abundance cytoplasmic proteins: L.A. O'Reilly, et al.; Biotechniques 25, 824 (1998), Methodology Abstract
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9: L.A. O'Reilly, et al.; Cell Death Differ. 9, 832 (2002), Methodology Abstract
Further Categories Containing This Product:
Inflammasome • Monoclonal Antibodies
 
 
ALX-804-355 Revised 14-Aug-07
Monoclonal Antibody to Caspase-2 (10C6)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-355-C100   100 µg 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Monkey
CLONE: 10C6
ISOTYPE: Rat IgG2a
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human caspase-2 (p19 subunit).
SPECIFICITY: Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2.
APPLICATION: ELISA
Flow Cytometry (1µg/ml)
Immunocytochemistry (10-20µg/ml; fix in 4% paraformaldehyde, 0.18% Triton-X100 for 10 min. prior to staining)
Immunohistochemistry (frozen sections)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
[1] Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9: L.A. O’Reilly, et al.; Cell Death Differ. 9, 832 (2002) Abstract; Full Text
[2] Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation: C.L. Scott, et al.; J. Cell Biol. 164, 89 (2004) Abstract; Full Text
[3] Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-356 Revised 05-Mar-07
Monoclonal Antibody to Caspase-2 (11B4)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-356-C100   100 µg 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Monkey
CLONE: 11B4
ISOTYPE: Rat IgG2a
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human caspase-2 p19 fragment.
SPECIFICITY: Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51kDa (procaspase-2), ~32kDa and ~18kDa (cleavage products) by Western blot.
APPLICATION: Immunoprecipitation
Western Blot (2µg/ml)
Note: For FC, ICC and IHC (FS) use MAb to Caspase-2 (10C6) (Prod. No. ALX-804-355).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
[1] Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9: L.A. O’Reilly, et al.; Cell Death Differ. 9, 832 (2002) Abstract; Full Text
[2] Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization: P. Lassus, et al.; Science 297, 1352 (2002) Abstract
[3] A novel Apaf-1-independent putative caspase-2 activation complex: S.H. Read, et al.; J. Cell Biol. 159, 739 (2002) Abstract; Full Text
[4] The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress: A. Tinel & J. Tschopp; Science 304, 843 (2004) Abstract
[5] BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis: A.G. Yakovlev, et al.; J. Biol. Chem. 279, 28367 (2004) Abstract; Full Text
[6] Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells: I.A. Camacho, et al.; J. Immunol. 175, 90 (2005) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-304 Revised 23-Apr-07
Monoclonal Antibody to Caspase-2 (human) (G310-1248)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-304-C100   100 µg 450.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: G310-1248
ISOTYPE: Mouse IgG
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity-purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human caspase-2.
SPECIFICITY: Recognizes both human caspase-2 long (~48kDa) and short forms.
APPLICATION: Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-305 Revised 03-Jul-08
Monoclonal Antibody to Caspase-3 (31A1067)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-305-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 31A1067
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
IMMUNOGEN: Recombinant human caspase-3.
SPECIFICITY: Recognizes human, mouse and rat procaspase-3 and cleaved 12 and 17kDa catalytic subunits of human caspase-3.
APPLICATION: Immunohistochemistry (frozen sections (see [4]), paraffin sections (see [18]))
Western Blot (2-3µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Images
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Product Specific Literature References
[1] Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax: S.M. Cuddeback, et al.; J. Biol. Chem. 276, 20559 (2001) Abstract; Full Text
[2] The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change: H. Yamaguchi and H.G. Wang; Oncogene 20, 7779 (2001) Abstract
[3] Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells: S.Y. Sun, et al.; Cancer Epidemiol. Biomarkers Prev. 10, 595 (2001) Abstract; Full Text
[4] Therapeutic time window of adenovirus-mediated GDNF gene transfer after transient middle cerebral artery occlusion in rat: W.R. Zhang, et al.; Brain Res. 947, 140 (2002) Abstract
[5] The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells: S.Y. Sun, et al.; Cancer Res. 62, 2430 (2002) Abstract; Full Text
[6] Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells: K.B. Kim, et al.; Mol. Cancer Ther. 1, 177 (2002) Abstract; Full Text
[7] Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production: Y.C. Chen, et al.; Biochem. Pharmacol. 64, 1713 (2002) Abstract
[8] Reversal of Taxol resistance in hepatoma by cyclosporin A: involvement of the PI-3 kinase-AKT 1 pathway: H.L. Lin, et al.; Br. J. Cancer 88, 973 (2003) Abstract
[9] Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation: L.F. Jarskog, et al.; Am. J. Psychiatry 161, 109 (2004) Abstract
[10] Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3: Y.H. Wu, et al.; J. Biol. Chem. 279, 19264 (2004) Abstract; Full Text
[11] Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3: Y.H. Wu, et al.; J. Biol. Chem. 279, 19264 (2004) Abstract; Full Text
[12] Hydroxylation at C4’ or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species: C.H. Ko, et al.; Free Radic. Biol. 36, 897 (2004) Abstract
[13] Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence: C. Douarre, et al.; Nucl. Acids Res. 33, 2192 (2005) Abstract; Full Text
Synergism of Rana catesbeiana ribonuclease and IFN-gamma triggers distinct death machineries in different human cancer cells: C.H. Tang, et al.; FEBS Lett. 579, 265 (2005) Abstract
[14] Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells: J.C. Lee, et al.; Carcinogenesis 26, 1716 (2005) Abstract
[15] Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma: P.C. Chiang, et al.; J. Hepatol. 43, 679 (2005) Abstract
[16] Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells: F. Jin, et al.; Cancer Res. 65, 6354 (2005) Abstract
[17] Induction of endothelial cell apoptosis by lipid hydroperoxide-derived bifunctional electrophiles: W. Jian, et al.; Free Radic. Biol. Med. 39, 1162 (2005) Abstract
[18] Protein expression profiling and molecular classification of gastric cancer by the tissue array method: H.S. Lee, et al.; Clin. Cancer Res. 13, 4154 (2007) Abstract
Further Categories Containing This Product:
Apoptosis & Necrosis Detection Other Products • Monoclonal Antibodies
 
 
ALX-804-307 Revised 19-Sep-05
Monoclonal Antibody to Caspase-6 (human) (B93-4)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-307-C100   100 µg 450.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: B93-4
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G affinity-purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 271-285 of human caspase-6. This sequence is not identical in mouse and rat.
SPECIFICITY: Recognizes human procaspase-6 and active human caspase-6. Detects bands of ~34kDa (procaspase-6) and 11kDa (active caspase-6) by Western blot.
APPLICATION: Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Images
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-242 Revised 19-Jun-08
Monoclonal Antibody to Caspase-8 (human) (12F5)
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SYNONYMS anti-FLICE (human) MAb (12F5)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-242-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 12F5
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥97% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In 0.15M PBS, pH 7.2, containing 1% BSA and 0.01% thimerosal.
IMMUNOGEN: Recombinant human caspase-8.
SPECIFICITY: Recognizes human procaspase-8 and active human caspase-8. Detects procaspase-8 (p55/54), the intermediate cleavage products  (p43/41) and the p18 active subunit of caspase-8 by Western blot. Does not recognize mouse caspase-8.
APPLICATION: Immunoprecipitation
Western Blot (1:500-1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis: D. Ferrari, et al.; J. Exp. Med. 188, 979 (1998) Abstract; Full Text
Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32): M. Bitzer, et al.; J. Virol. 73, 702 (1999) Abstract; Full Text
P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death: D. Ferrari, et al.; FEBS Lett. 447, 71 (1999) Abstract
Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction: S. Wesselborg, et al.; Blood 93, 3053 (1999) Abstract; Full Text
IL-10 induces apoptosis in human monocytes involving the CD95 receptor/ligand pathway: M. Schmidt, et al.; Eur. J. Immunol. 30, 1769 (2000) Abstract
Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD): H. Wajant, et al.; J. Biol. Chem. 275, 24357 (2000) Abstract; Full Text
Trail-induced apoptosis in Type I leukemic cells is not enhanced by overexpression of bax: L. Jia, et al.; BBRC 283, 1037 (2001) Abstract
Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway: D. Siegmund, et al.; J. Biol. Chem. 276, 32585 (2001) Abstract; Full Text
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis: Y. Kim, et al.; J. Biol. Chem. 277, 22320 (2002) Abstract; Full Text
Constitutive caspase activation and impaired death-inducing signaling complex formation in CD95-resistant, long-term activated, antigen-specific T cells: G. Strauss, et al.; J. Immunol. 171, 1172 (2003) Abstract; Full Text
A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis
 : V. Oliveira, et al.; J. Biol. Chem. 283, 13174 (2008) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-429 Revised 18-Sep-07
Monoclonal Antibody to Caspase-8 (human) (C15)
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SYNONYMS anti-FLICE (human) MAb (C15)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-429-C050   50 µg 195.00 USD Add To Cart
ALX-804-429-C100   100 µg 325.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: C15
ISOTYPE: Mouse IgG2b
SOURCE/HOST: The antibody was purified from hybridoma tissue culture supernatant.
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE).
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human caspase-8  (aa 181-478).
SPECIFICITY: Recognizes the p18 subunit of human caspase-8.
APPLICATION: Immunocytochemistry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b: C. Scaffidi, et al.; J. Biol. Chem. 272, 26953 (1997) Abstract; Full Text
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8: M.R. Sprick, et al.; EMBO J. 21, 4520 (2002)