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Toll-IL-1 Receptor Adaptors & TLR Downstream Signalling
You are here: Product Lines > Inflammation > Toll-IL-1 Receptor Adaptors & TLR Downstream Signalling
 
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ALX-306-022 Revised 07-Feb-05
D-erythro-Sphingosine chloride, N,N,N-Trimethyl-
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SYNONYMS N,N,N-Trimethyl-D-erythro-sphingosine chloride
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Ceramides / Cerebrosides / Sphingolipids / Related Products
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ALX-306-022-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C21H44ClNO2
MW: 378.0
SOURCE/HOST: Synthetic.
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in water, methanol or DMSO; slightly soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Hygroscopic.

Product Description
Stable N-methylated derivative of sphingosine that exhibits antitumor and anti-inflammatory properties and inhibits platelet activating factor (PAF) activation and protein kinase C (PKC) activity. Inhibits IL-1β-induced NF-κB activation and cell surface expression of crucial selectins which promote adhesion of Lex- or sialosyl-Lex-expressing cells with platelets and endothelial cells.
Product Specific Literature References
Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine: K. Handa, et al.; Biochemistry 30, 11682 (1991) Abstract
Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line: H. Okoshi, et al.; Cancer Res. 51, 6019 (1991) Abstract
Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils: S. Kimura, et al.; Biochem. Pharmacol. 44, 1585 (1992) Abstract
Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III: Y.S. Park, et al.; Cancer Res. 54, 2213 (1994) Abstract
N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells: A. Masamune, et al.; FEBS Lett. 367, 205 (1995) Abstract
Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors: T. Murohara, et al.; Circ. Res. 78, 780 (1996) Abstract; Full Text
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • PKC Inhibitors • NF-kB Pathway Inhibitors • Anti-inflammatory Agents Other Products
 
 
ALX-430-105 Revised 10-Dec-04
Sulindac
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SYNONYMS MK-231
(1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]-indene-3-acetic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-105-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C20H17FO3S
MW: 356.4
CAS NUMBER: 38194-50-2
MERCK INDEX: 14: 8982
RTECS: NK8226000
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or aqueous bases.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Inhibits the NF-κB pathway. Non-steroidal anti-inflammatory drug. Reduces the level and activity of several cyclin-dependent kinases (CDKs) and induces apoptosis. For the active metabolite sulindac sulfide see Prod. No. ALX-430-106.
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • COX Inhibitors • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-430-106 Revised 31-Aug-04
Sulindac sulfide
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-106-M005   5 mg 32.00 USD Add To Cart
ALX-430-106-M025   25 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C20H17FO2S
MW: 340.4
CAS NUMBER: 32004-67-4
PURITY: ≥98%
APPEARANCE: Yellow-orange solid.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Active metabolite of sulindac (Prod. Nr. ALX-430-105). NF-κB inhibitor. Induces apoptosis. Inhibits Ras signaling. Also inhibits cyclooxygenase (COX).
Product Specific Literature References
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis: G.A. Piazza, et al.; Cancer Res. 55, 3110 (1995) Abstract
Sulindac sulfide inhibits Ras signaling: C. Herrmann, et al.; Oncogene 17, 1769 (1998) Abstract
Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem. 274, 27307 (1999) Abstract; Full Text
Further Categories Containing This Product:
COX Inhibitors • Apoptosis Inducers & Inhibitors Other Products • NF-kB Pathway Inhibitors
 
 
ALX-430-107 Revised 20-Aug-08
Sulindac sulfone
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-107-M005   5 mg 30.00 USD Add To Cart
ALX-430-107-M050   50 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H17FO4S
MW: 372.4
CAS NUMBER: 59864-04-9
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Metabolite of sulindac (Prod. No. ALX-430-105).
Product Specific Literature References
Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem. 274, 27307 (1999) Abstract; Full Text
Further Categories Containing This Product:
COX Inhibitors • NF-kB Pathway Inhibitors
 
 
ALX-350-261 Revised 08-Apr-08
Trichodion
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-261-C100   100 µg 85.00 USD Add To Cart
ALX-350-261-C500   500 µg 250.00 USD Add To Cart
Product Specification
FORMULA: C12H14O5
MW: 238.2
SOURCE/HOST: Isolated from Trichosporiella sp.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: CYTOTOXIC.

Product Description
Inhibits NF-κB (IC50=42-84µM), AP-1 (IC50=21µM) and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS ll) expression.
Product Specific Literature References
Trichodion, a new inhibitor of inflammatory signal transduction pathways from a Trichosporiella species: G. Erkel; FEBS Lett. 477, 219 (2000) Abstract; Full Text
Trichodion, a new bioactive pyrone from a Trichosporiella species: G. Erkel, et al.; J. Antibiot. (Tokyo) 53, 1401 (2000) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • COX Inhibitors • NF-kB Pathway Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Other Natural Products for Inflammation Research
 
 
ALX-350-259 Revised 17-Dec-07
Triptolide
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SYNONYMS PG490
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Immunomodulators
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ALX-350-259-M001   1 mg 70.00 USD Add To Cart
ALX-350-259-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C20H24O6
MW: 360.4
CAS NUMBER: 38748-32-2
SOURCE/HOST: Isolated from Tripterygium wilfordii.
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Immunosuppressive agent with anti-inflammatory and antitumor properties. More effective in preventing T cell proliferation and interferon-γ production than FK506 (Prod. No. ALX-380-008). Induces apoptosis in T cells by activating DEVD cleaving caspases. Blocks TNF-α mediated induction of c-IAP1 and c-IAP2 and NF-κB activation.
Product Specific Literature References
Triptolide induces apoptotic death of T lymphocyte: Y. Yang, et al.; Immunopharmacology 40, 139 (1998) Abstract
Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506: M.A. Chan, et al.; Phytother. Res. 13, 464 (1999) Abstract
Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T- cells and NF-kappaB transcriptional activation: D. Qiu, et al.; J. Biol. Chem. 274, 13443 (1999) Abstract; Full Text
PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells: K.Y. Lee, et al.; J. Biol. Chem. 274, 13451 (1999) Abstract; Full Text
Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f:: D. Qiu & P.N. Kao; Drugs R. D. 4, 1 (2003), (Review) Abstract
Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells: Y. Miyata, et al.; BBRC 336, 1081 (2005) Abstract
Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death: S.D. Westerheide, et al.; J. Biol. Chem. 281, 9616 (2006) Abstract
Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells: B.Z. Carter, et al.; Blood 108, 630 (2006) Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Antitumor Reagents • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-350-153 Revised 28-Jul-08
Withaferin A
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SYNONYMS 5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-153-M001   1 mg 60.00 USD Add To Cart
ALX-350-153-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C28H38O6
MW: 470.6
CAS NUMBER: 5119-48-2
MERCK INDEX: 14: 10048
RTECS: KE7288500
SOURCE/HOST: Isolated from Withania somnifera.
PURITY: ≥94% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (20 mg/ml), methanol (10 mg/ml) or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: MAY BE MUTAGENIC. MAY BE CARCINOGENIC. HARMFUL.

Product Description
Cell permeable and potent angiogenesis inhibitor from the family of withanolides. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50=12nM) and in vivo. Exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits NF-κB activation by preventing the TNF-induced activation of IκB kinase β (IKKβ). Affects AP1 transcription and induces cell death. Alters cytoskeletal architecture by covalently binding annexin II and stimulating its basal F-actin cross-linking activity which inhibits the migratory and invasive capability of endothelial cells. Displays neuronal regenerative properties. Targets the intermediate filament protein vimentin.
Product Specific Literature References
Tumor inhibitors. XXXIX. Active principles of Acnistus arborescens. Isolation and structural and spectral studies of withaferin A and withacnistin: S.M. Kupchan, et al.; J. Org. Chem. 34, 3858 (1969) Abstract
In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma: P.U. Devi, et al.; Cancer Lett. 95, 189 (1995) Abstract
Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves: B. Jayaprakasam, et al.; Life Sci. 74, 125 (2003) Abstract
Withaferin A is a potent inhibitor of angiogenesis: R. Mohan, et al.; Angiogenesis 7, 115 (2004) Abstract
Neuritic regeneration and synaptic reconstruction induced by withanolide: A: T. Kuboyama, et al.; Br. J. Pharmacol. 144, 961 (2005) Abstract; Full Text
Actin microfilament aggregation induced by withaferin A is mediated by annexin II: R.R. Falsey, et al.; Nat. Chem. Biol. 2, 33 (2006) Abstract
Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity: M. Kaileh, et al.; J. Biol. Chem. 282, 4253 (2007) Abstract; Full Text
The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin: P. Bargagna-Mohan, et al.; Chem. Biol. 14, 623 (2007) Abstract
Further Categories Containing This Product:
Natural Products for Angiogenesis Research • NF-kB Pathway Inhibitors • Natural Products - NF-kB Pathway Inhibitors • Natural Products for Cytoskeletal Research • Natural Products - Anti-inflammatory Agents • Natural Products - Immunomodulators • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-260-166 Revised 07-Apr-08 New product
Z-VRPR-FMK
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SYNONYMS Z-Val-Arg-Pro-DL-Arg-FMK . TFA
MALT1 Inhibitor
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-260-166-MC05   0.5 mg 280.00 USD Add To Cart
ALX-260-166-M001   1 mg 520.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Arg-Pro-DL-Arg-fluoromethylketone
FORMULA: C31H49FN10O6 . C2HF3O2
MW: 676.8 . 114.0
PURITY: ≥90% (HPLC)
APPEARANCE: White to slightly yellow powder.
SOLUBILITY: Soluble in water (1mg/ml).
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Description
Inhibits the proteolytic activity of the paracaspase MALT1. MALT1 impairs TCR-induced activation of NF-κB and production of IL-2. It does not affect viability or morphology of cells. The proteolytic activity of MALT1 is key to T cell activation.
Product Specific Literature References
The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008) Abstract
Further Categories Containing This Product:
T Cell Signalling Other Products • NF-kB Pathway Inhibitors
 
 
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