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ALX-260-046
Revised 06-Jun-08
Ac-AAVALLPAVLLALLAPDEVD-CHO
SYNONYMS
Caspase-3 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-046-M001
1 mg
70.00 USD
ALX-260-046-M005
5 mg
290.00 USD
Product Specification
SEQUENCE:
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
FORMULA:
C
94
H
158
N
20
O
27
MW:
2000.4
PEPTIDE CONTENT:
65-95%.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
FORMULATION:
Lyophilized. TFA salt.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry. After dissolving, prepare aliquots and store at -20°C
Product Description
Reversible, cell permeable inhibitor of caspase-3. Also inhibits caspase-6, -7, -8 and -10.
Product Specific Literature References
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis:
W. Nicholson, et al.; Nature
376
, 37 (1995)
Abstract
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase:
M. Tewari, et al.; Cell
81
, 801 (1995)
Abstract
Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity:
S.C. Wright, et al.; J. Exp. Med.
186
, 1107 (1997)
Abstract
ALX-260-047
Revised 27-Aug-08
Ac-AAVALLPAVLLALLAPYVAD-CHO
SYNONYMS
Caspase-1 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-047-M001
1 mg
170.00 USD
ALX-260-047-M005
5 mg
680.00 USD
Product Specification
SEQUENCE:
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
FORMULA:
C
97
H
160
N
20
O
24
MW:
1990.5
PEPTIDE CONTENT:
78-98%
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO (0.25mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Reversible, cell permeable inhibitor of caspase-1.
ALX-260-158
Revised 16-Feb-05
Ac-AEVD-CHO
SYNONYMS
Caspase-10 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-158-M001
1 mg
60.00 USD
ALX-260-158-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
Z-Ala-Glu-Val-Asp-aldehyde
FORMULA:
C
19
H
30
N
4
O
9
MW:
458.5
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of caspase-10. Also inhibits caspase-6 and -8.
ALX-260-030
Revised 05-Jun-08
Ac-DEVD-CHO
SYNONYMS
Caspase-3 Inhibitor (Aldehyde)
Caspase-7 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-030-M001
1 mg
47.00 USD
ALX-260-030-M005
5 mg
183.00 USD
Product Specification
SEQUENCE:
Ac-Asp-Glu-Val-Asp-CHO
FORMULA:
C
20
H
30
N
4
O
11
MW:
502.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥95% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in distilled water or DMSO.
RECONSTITUTION:
Add 0.2ml DMSO per 1mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C. Solutions are stable for at least 1 month when stored at -20°C in the dark and protected from moisture.
HANDLING:
Keep cool and dry. Keep under nitrogen.
Product Description
Reversible inhibitor of caspase-3 and -7.
Product Specific Literature References
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis:
D.W. Nicholson, et al.; Nature
376
, 37 (1995)
Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis:
M. Enari, et al.; Nature
380
, 723 (1996)
Abstract
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis:
D.W. Nicholson; Nature Biotechnol.
14
, 297 (1996)
Abstract
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis:
J. Schlegel, et al.; J. Biol. Chem.
271
, 1841 (1996)
Abstract
;
Full Text
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Inhibition of human caspases by peptide-based and macromolecular inhibitors:
M. Garcia-Calvo, et al.; J. Biol. Chem.
273
, 32608 (1998)
Abstract
;
Full Text
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells:
X.M. Zhang, et al.; Biochem. J.
340
, 127 (1999)
Abstract
;
Full Text
ALX-260-077
Revised 10-Feb-05
Ac-DMQD-CHO
SYNONYMS
Caspase-3 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-077-M001
1 mg
62.00 USD
ALX-260-077-M005
5 mg
243.00 USD
Product Specification
SEQUENCE:
Ac-Asp-Met-Gln-Asp-CHO
FORMULA:
C
20
H
31
N
5
O
10
S
MW:
533.6
PEPTIDE CONTENT:
70-90%.
PURITY:
≥96% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in distilled water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-3. Together with the caspase-6 inhibitor Ac-VEID-CHO (Prod. No.
ALX-260-062
) this inhibitor has been used to dissect the pathway of caspase activation in Fas-stimulated Jurkat cells.
Product Specific Literature References
Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis:
H. Hirata, et al.; J. Exp. Med.
187
, 587 (1998)
Abstract
ALX-260-056
Revised 11-Dec-07
Ac-ESMD-CHO
SYNONYMS
Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-056-M001
1 mg
83.00 USD
ALX-260-056-M005
5 mg
325.00 USD
Product Specification
SEQUENCE:
Ac-Glu-Ser-Met-Asp-CHO
FORMULA:
C
19
H
30
N
4
O
10
S
MW:
506.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥99% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in distilled water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Use always fresh solutions.
HANDLING:
Keep cool and dry. Keep under inert gas.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-6 and -10. The peptide sequence corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-043
Revised 13-Nov-06
Ac-IETD-CHO
SYNONYMS
Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-043-M001
1 mg
62.00 USD
ALX-260-043-M005
5 mg
243.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-CHO
FORMULA:
C
21
H
34
N
4
O
10
MW:
502.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Use always fresh solutions.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-10.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-160
Revised 01-Oct-07
Ac-LDESD-CHO
SYNONYMS
Caspase-2 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-160-M001
1 mg
50.00 USD
ALX-260-160-M005
5 mg
200.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Asp-Glu-Ser-Asp-CHO
FORMULA:
C
24
H
37
N
5
O
13
MW:
603.6
PEPTIDE CONTENT:
70-95%
PURITY:
≥95% (HPLC)
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in DMSO or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Reversible inhibitor of caspase-2.
Product Specific Literature References
Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis:
E. Swanton, et al.; J. Biol. Chem.
274
, 37583 (1999)
Abstract
ALX-260-079
Revised 13-Nov-06
Ac-LEHD-CHO
SYNONYMS
Caspase-9 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-079-M001
1 mg
62.00 USD
ALX-260-079-M005
5 mg
243.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Glu-His-Asp-CHO
FORMULA:
C
23
H
34
N
6
O
9
MW:
538.6
PEPTIDE CONTENT:
75-95%
PURITY:
≥95%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Further dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Keep sealed after removing from the freezer until its temperature equilibrates with room temperature. Dissolve only amount needed at a time to avoid decomposition in solution.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-9.
ALX-260-065
Revised 11-Dec-07
Ac-LEVD-CHO
SYNONYMS
Caspase-4 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-065-M001
1 mg
52.00 USD
ALX-260-065-M005
5 mg
223.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Glu-Val-Asp-CHO
FORMULA:
C
22
H
36
N
4
O
9
MW:
500.6
PEPTIDE CONTENT:
70-90%.
PURITY:
≥95% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in distilled water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-4. Also inhibits caspase-5.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
R.V. Talanian, et al.; J. Biol. Chem.
272
, 9677 (1997)
Abstract
;
Full Text
ALX-260-058
Revised 10-Feb-05
Ac-VDVAD-CHO
SYNONYMS
Caspase-2 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-058-M001
1 mg
62.00 USD
ALX-260-058-M005
5 mg
243.00 USD
Product Specification
SEQUENCE:
Ac-Val-Asp-Val-Ala-Asp-CHO
FORMULA:
C
23
H
37
N
5
O
10
MW:
543.6
PEPTIDE CONTENT:
70-90%.
PURITY:
≥94% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO or buffer (pH 7-7.5).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-2.
Product Specific Literature References
Substrate specificities of caspase family proteases:
R.V. Talanian, et al.; J. Biol. Chem.
272
, 9677 (1997)
Abstract
;
Full Text
ALX-260-062
Revised 30-Oct-08
