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ALX-210-904
Revised 25-Jan-08
Polyclonal Antibody to NALP1 (human) (AL176)
SYNONYMS
anti-NACHT-, LRR- and PYD-containing Protein 1 (human) PAb (AL176)
anti-DEFCAP (human) PAb (AL176)
anti-NAC (human) PAb (AL176)
anti-CARD7 (human) PAb (AL176)
anti-Caspase Recruitment Domain-containing Protein 7 (human) PAb (AL176)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-904-R100
100 µl
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
PURITY:
Affinity purified.
FORMULATION:
Liquid. Neat serum.
IMMUNOGEN:
Synthetic peptide corresponding to aa 2-25 (A
2
GGAWGRLACYLEFLKKEELKEFQ
25
) of N-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY:
Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-603
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
:
F. Martinon; Mol. Cell.
10
, 417 (2002)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Signalling: Initiation of pro-IL-1beta processing
:
E. Bell; Nat. Rev. Immunol.
2
, 719 (2002), (Review)
Abstract
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1
:
S.M. Srinivasula, et al.; J. Biol. Chem.
277
, 21119 (2002)
Abstract
NALPS: a novel protein family involved in inflammation
:
J. Tschopp, et al.; Nat. Rev. Mol. Cell Biol.
4
, 95 (2003), (Review)
Abstract
;
Full Text
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Polyclonal Antibodies
ALX-210-017
Revised 12-Apr-07
Polyclonal Antibody to NALP1 (human) (CT) (Bur 242)
SYNONYMS
anti-NACHT-, LRR- and PYD-containing Protein 1 (human) (CT) PAb (Bur 242)
anti-DEFCAP (human) (CT) PAb (Bur 242)
anti-NAC (human) (CT) PAb (Bur 242)
anti-CARD7 (human) (CT) PAb (Bur 242)
anti-Caspase Recruitment Domain-containing Protein 7 (human) (CT) PAb (Bur 242)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-017-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1058-1077 (C
1058
VPSPASQGDLHTKPLGTDD
1077
) of C-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY:
Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION:
Immunohistochemistry (paraffin sections)
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-603
.
Product Specific Literature References
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis
:
Z.L. Chu, et al.; J. Biol. Chem.
276
, 9239 (2001)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Polyclonal Antibodies
ALX-210-018
Revised 12-Apr-07
Polyclonal Antibody to NALP1 (human) (NT) (Bur 241)
SYNONYMS
anti-NACHT-, LRR- and PYD-containing Protein 1 (human) (NT) PAb (Bur 241)
anti-DEFCAP (human) (NT) PAb (Bur 241)
anti-NAC (human) (NT) PAb (Bur 241)
anti-CARD7 (human) (NT) PAb (Bur 241)
anti-Caspase Recruitment Domain-containing Protein 7 (human) (NT) PAb (Bur 241)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-018-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 161-180 (P
161
SSPDHESPSQESPNAPTST
180
) of N-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY:
Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION:
Immunohistochemistry (paraffin sections)
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-603
.
Product Specific Literature References
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis
:
Z.L. Chu, et al.; J. Biol. Chem.
276
, 9239 (2001)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Polyclonal Antibodies
ALX-210-576
Revised 18-Oct-07
Polyclonal Antibody to NF-κB (p50)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Transcription Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-576-R100
100 µl
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human NF-κB (p50 subunit).
SPECIFICITY:
Recognizes human NF-κB (p50 subunit).
APPLICATION:
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for one week when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-574
Revised 18-Oct-07
Polyclonal Antibody to NF-κB (p65)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Transcription Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-210-574-R100
100 µl
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human NF-κB (p65 subunit).
SPECIFICITY:
Recognizes human and mouse NF-κB (p65 subunit).
APPLICATION:
Immunocytochemistry (1:500-1:1’000)
Immunohistochemistry (paraffin sections (1:500-1:1’000))
Immunoprecipitation (2µg)
Western Blot (1:2’000-1:5’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for one week when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1:
P.O. Hassa, et al.; J. Biol. Chem.
278
, 45145 (2003)
Abstract
;
Full Text
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription:
P.O. Hassa, et al.; J. Biol. Chem.
280
, 40450 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-949
Revised 29-Oct-07
Polyclonal Antibody to Pannexin-1 (human) (AT124)
SYNONYMS
anti-Pannexin-1 (human) PAb (AT124)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-949-C100
100 µg
350.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to 15 aa near the C-terminus of human pannexin-1.
SPECIFICITY:
Recognizes human pannexin-1.
APPLICATION:
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Pannexin-1 belongs to a new family of membrane proteins with homology to invertebrate gap junction proteins innexins. Pannexin-1 has recently been involved in the NALP (inflammasome)-mediated caspase-1 activation and IL-1β secretion.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling:
T.D. Kanneganti, et al.; Immunity
26
, 433 (2007)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-946
Revised 10-Oct-07
Polyclonal Antibody to Pyrin (human) (AL196)
SYNONYMS
anti-MEFV (human) PAb (AL196)
anti-Mediterranean Fever Protein (AL196)
anti-Marenostrin (human) PAb (AL196)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-946-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 2-29 (A
2
KTPSDHLLSTLEELVPYDFEKFKFKLQ
29
) of human pyrin (MEFV; mediterranean fever protein).
SPECIFICITY:
Recognizes human pyrin.
APPLICATION:
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing:
S. Papin, et al.; Cell Death Differ.
14
, 1457 (2007)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-932
Revised 28-Feb-07
Polyclonal Antibody to RIG-I (human) (AT111)
SYNONYMS
anti-RIG-1 (human) PAb (AT111)
anti-Retinoic Acid-inducible Gene 1 Protein (human) PAb (AT111)
anti-DEAD-box Protein 58 (human) PAb (AT111)
anti-Probable ATP-dependent RNA Helicase DDX58 (human) PAb (AT111)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-932-C100
100 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RIG-I (retinoic acid-inducible gene 1 protein) (aa 201-713).
SPECIFICITY:
Recognizes human RIG-I.
APPLICATION:
Immunoprecipitation (1:100)
Western blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
RIG-I (retinoic acid-inducible gene I; Ddx58), a member of the DEAD-box RNA helicases, is activated by cytoplasmic dsRNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-β (Cardif) in a CARD-CARD-dependent manner resulting in NF-κB and IRF3 activation.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Virology. Sensing viral RNA amid your own:
T. Fujita; Science
314
, 935 (2006)
Abstract
5’-Triphosphate RNA is the ligand for RIG-I:
V. Hornung, et al.; Science
314
, 994 (2006)
Abstract
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates:
A. Pichlmair, et al.; Science
314
, 997 (2006)
Abstract
Related Products
ALX-804-849
Monoclonal Antibody to RIG-I (Alme-1)
ALX-840-609
Positive Control (Cell Lysate) for Antibodies to RIG-I (human)
APO-54N-038
RIG-I (human) (IntraCellular) Detection Set [For ELISA Application]
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
NF-kB Pathway Other Products
•
Antiviral Signalling / Related Products
•
Interferons & Interferon Receptors Other Products
•
Polyclonal Antibodies
ALX-210-392
Revised 12-Jul-06
Polyclonal Antibody to SOCS-1
SYNONYMS
anti-Suppressor of Cytokine Signalling-1 PAb
anti-JAB PAb
anti-SSI-1 PAb
anti-TIP-3 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SOCS / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-392-R200
200 µl
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.1mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide containing aa residues of human SOCS-1 (suppressor of cytokine signalling-1).
SPECIFICITY:
Recognizes human and mouse SOCS-1.
APPLICATION:
Western Blot (1:500 - 1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
SOCS-1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signalling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin. SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signalling.
General Literature References
SOCS proteins: negative regulators of cytokine signaling
:
D.L. Krebs and D.J. Hilton; Stem Cells
19
, 378 (2001)
Abstract
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
:
I. Kinjyo, et al.; Immunity
17
, 583 (2002)
Abstract
A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts
:
S. Ilangumaran, et al.; J. Immunol.
169
, 5010 (2002)
Abstract
Further Categories Containing This Product:
Toll-IL-1 Receptor Adapters & TLR Downstream Signalling Other Products
•
Polyclonal Antibodies
ALX-210-366
Revised 23-Sep-05
Polyclonal Antibody to TIRAP (Pearl-1)
SYNONYMS
anti-Toll-interleukin 1 Receptor Domain-containing Adapter Protein PAb (Pearl-1)
anti-Mal PAb (Pearl-1)
anti-MyD88 Adapter-like Protein PAb (Pearl-1)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-366-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human TIRAP (Mal).
SPECIFICITY:
Recognizes human and mouse TIRAP (Mal). Does not cross-react with MyD88.
APPLICATION:
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
General Literature References
The Toll-IL-1 receptor adaptor family grows to five members
:
L.A. O'Neill; Trends. Immunol.
24
, 286 (2003)
Further Categories Containing This Product:
Polyclonal Antibodies
