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Inflammation
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ALX-581-020 Revised 12-Feb-08
LPS from Salmonella minnesota S-Form (TLRgrade™) (liquid)
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SYNONYMS Lipopolysaccharide from Salmonella minnesota S-Form (TLRgrade™) (liquid)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-020-L002   2 ml 155.00 USD Add To Cart
Product Specification
SOURCE/HOST: Smooth (S)-form LPS isolated and purified from Salmonella minnesota (wild type) by a modification of the PCP extraction method [1,2], converted to the uniform sodium salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Specific activator of Toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Use must be restricted to qualified personnel. Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream. Keep sterile.
HAZARD: HARMFUL. HIGHLY PYROGENIC.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Meth. Carbohydr. Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
 
 
ALX-581-200 Revised 26-Apr-07
Lipid A from E. coli, Serotype R515 (Re) (TLRgrade™) (liquid)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-200-L002   2 ml 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Isolated from E. coli R515 (Re mutant). Prepared by mild acid hydrolysis from purified Escherichia coli R515 (Re) LPS (isolated by a modification of the PCP extraction method [1,2]), converted to the uniform salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: ≥99.9% (regarding protein or DNA contaminants; KDO not detectable)
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Activates Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep sterile.
HAZARD: HARMFUL. HIGHLY PYROGENIC.
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Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides  : C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides  : C. Galanos & O. Luderitz; Methods in Carbohydrate Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms  : C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells: M. Huber, et al.; Eur. J. Immunol. 36, 701 (2006) Abstract
 
 
ALX-581-201 Revised 26-Apr-07
Lipid A from Salmonella minnesota R595 (Re) (TLRgrade™) (liquid)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-201-L002   2 ml 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Isolated from Salmonella minnesota R595 (Re mutant). Prepared by mild acid hydrolysis from purified Salmonella minnesota R595 (Re) LPS (isolated by a modification of the PCP extraction method [1,2]), converted to the uniform salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: ≥99.9% (regarding protein or DNA contaminants; KDO not detectable)
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Activates Toll-like receptor (TLR) 4. Does not activate TLR2 as determined with splenocytes and macrophages from TLR4 deficient mice.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep sterile.
HAZARD: HARMFUL. HIGHLY PYROGENIC.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides : C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides  : C. Galanos & O. Luderitz; Methods in Carbohydrate Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms  : C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] CD14 is required for MyD88-independent LPS signaling: Z. Jiang, et al.; Nat. Immunol. 6, 565 (2005) Abstract
[5] IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella Enteritidis and the impact of IL-10 in bone marrow-derived macrophages: N. Schuetze, et al.; Int. Immunol. 17, 649 (2005) Abstract
 
 
ALX-581-202 Revised 26-Apr-07
Monophosphoryl Lipid A from Salmonella minnesota R595 (Re) (TLRgrade™) (liquid)
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SYNONYMS MPL-A from Salmonella minnesota R595 (Re) (TLRgrade™) (liquid)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS]/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-202-L001   1 ml 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Isolated from Salmonella minnesota R595 (Re mutant). Prepared by acid hydrolysis from purified Salmonella minnesota R595 (Re) LPS (isolated by a modification of the PCP extraction method [1,2]), converted to the uniform salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: ≥99.9% (regarding protein or DNA contaminants; KDO not detectable)
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Activates Toll-like receptor (TLR) 4. Does not activate TLR2 as determined with splenocytes and macrophages from TLR4 deficient mice. Essentially lacks the endotoxic and pyrogenic activity of lipid A.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep sterile.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides : C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides  : C. Galanos & O. Luderitz; Meth. Carbohydr. Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms  : C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
 
 
ALX-746-001 Revised 06-Oct-06
ODN 1668 (TLRgrade™) (synthetic)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Oligodeoxynucleotides [ODNs]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-746-001-T100   100 tests 155.00 USD Add To Cart
Product Specification
SEQUENCE: 5’-tccatgacgttcctgatgct-3’
(lower case letters indicate phosphorothioate linkage).
MW: 6383 (ammonium salt)
SOURCE/HOST: Synthetic.
QUANTITY: 15nmol (~96µg). Sufficient for at least 100 cellular activation assays at 0.1-0.5µg/well when performed in a 200µl assay volume (i.e. 96 well microtiter plate).
PURITY DETAIL: Activity and endotoxin tested - TLRgrade™.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 100µM stock solution, dissolve the total vial content in 150µl endotoxin-free water (included) or PBS (to order seperately).
To obtain optimal dissolving we recommend the following procedure:
- Add 50% of the solvent and let dissolve for 10 min.
- Add remaining 50% of the solvent and mix thoroughly.
- Moderate warming may aid dissolving.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Aqueous stock solution is stable for 1 day when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Protect from light.
Product Images
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Product Description
CpG oligodeoxynucleotide (Type B) with phosphorothioate backbone. Specific ligand for mouse TLR9 (Toll-like receptor 9).
General Information
BACKGROUND/TECHNICAL INFORMATION

Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).

Related Products:

- PBS (endotoxin-free) (Prod. No. ALX-505-007)

- ODN 1720 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-200)

- iODN 2088 (TLRgrade™) (synthetic) (Inhibitory for mouse) (Prod. No. ALX-746-250)
Related Products
 
 
ALX-746-002 Revised 06-Oct-06
ODN 1826 (TLRgrade™) (synthetic)
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SYNONYMS CpG-B (TLRgrade™) (synthetic)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Oligodeoxynucleotides [ODNs]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-746-002-T100   100 tests 155.00 USD Add To Cart
Product Specification
SEQUENCE: 5’-tccatgacgttcctgacgtt-3’
(lower case letters indicate phosphorothioate linkage).
MW: 6383 (ammonium salt)
SOURCE/HOST: Synthetic.
QUANTITY: 15nmol (~96µg). Sufficient for at least 100 cellular activation assays at 0.1-0.5µg/well when performed in a 200µl assay volume (i.e. 96 well microtiter plate).
PURITY DETAIL: Activity and endotoxin tested - TLRgrade™.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 100µM stock solution, dissolve the total vial content in 150µl endotoxin-free water (included) or PBS (to order seperately).
To obtain optimal dissolving we recommend the following procedure:
- Add 50% of the solvent and let dissolve for 10 min.
- Add remaining 50% of the solvent and mix thoroughly.
- Moderate warming may aid dissolving.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Aqueous stock solution is stable for 1 day when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Description
CpG oligodeoxynucleotide (Type B) with phosphorothioate backbone. Specific ligand for mouse TLR9 (Toll-like receptor 9). For inactive control compound see ODN 1982 (Prod. No. ALX-746-201).
General Information
BACKGROUND/TECHNICAL INFORMATION

Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).

Related Products:

- PBS (endotoxin-free) (Prod. No. ALX-505-007)

- ODN 1982 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-201)

- iODN 2088 (TLRgrade™) (synthetic) (Inhibitory for mouse) (Prod. No. ALX-746-250)
Related Products
 
 
ALX-746-003 Revised 06-Oct-06
ODN 1585 (TLRgrade™) (synthetic)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Oligodeoxynucleotides [ODNs]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-746-003-T100   100 tests 155.00 USD Add To Cart
Product Specification
SEQUENCE: 5’-ggGGTCAACGTTGAgggggg-3’
(lower case letters indicate phosphorothioate linkage).
MW: 6643 (ammonium salt)
SOURCE/HOST: Synthetic.
QUANTITY: 14.9nmol (~99µg). Sufficient for at least 100 cellular activation assays at 0.1-0.5µg/well when performed in a 200µl assay volume (i.e. 96 well microtiter plate).
PURITY DETAIL: Activity and endotoxin tested - TLRgrade™.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 100µM stock solution, dissolve the total vial content in 149µl endotoxin-free water (included) or PBS (to order seperately).
To obtain optimal dissolving we recommend the following procedure:
- Add 50% of the solvent and let dissolve for 10 min.
- Add remaining 50% of the solvent and mix thoroughly.
- Moderate warming may aid dissolving.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Aqueous stock solution is stable for 1 day when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Protect from light.
Product Description
CpG oligodeoxynucleotide (Type A) with mixed phosphodiester/phosphorothioate backbone. Specific ligand for mouse TLR9 (Toll-like receptor 9). For inactive control compound see ODN 2118 (Prod. No. ALX-746-203).
General Information
BACKGROUND/TECHNICAL INFORMATION

Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).

Related Products:

- PBS (endotoxin-free) (Prod. No. ALX-505-007)

- ODN 2118 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-203)

- iODN 2088 (TLRgrade™) (synthetic) (Inhibitory for mouse) (Prod. No. ALX-746-250)
Related Products
 
 
ALX-746-004 Revised 06-Oct-06
ODN M362 (TLRgrade™) (synthetic)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Oligodeoxynucleotides [ODNs]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-746-004-T100   100 tests 155.00 USD Add To Cart
Product Specification
SEQUENCE: 5’-tcgtcgtcgttcgaacgacgttgat-3’
(lower case letters indicate phosphorothioate linkage).
MW: 8073 (ammonium salt)
SOURCE/HOST: Synthetic.
QUANTITY: 12.2nmol (~98µg). Sufficient for at least 100 cellular activation assays at 0.1-0.5µg/well when performed in a 200µl assay volume (i.e. 96 well microtiter plate).
PURITY DETAIL: Activity and endotoxin tested - TLRgrade™.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 100µM stock solution, dissolve the total vial content in 122µl endotoxin-free water (included) or PBS (to order seperately).
To obtain optimal dissolving we recommend the following procedure:
- Add 50% of the solvent and let dissolve for 10 min.
- Add remaining 50% of the solvent and mix thoroughly.
- Moderate warming may aid dissolving.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY:

Aqueous stock solution is stable for 1 day when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Description
CpG oligodeoxynucleotide (Type C) with phosphorothioate backbone. Specific ligand for TLR9 (Toll-like receptor 9). For inactive control compound see ODN M383 (Prod. No. ALX-746-204).
General Information
BACKGROUND/TECHNICAL INFORMATION

Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).

Related Products:

- PBS (endotoxin-free) (Prod. No. ALX-505-007)

- ODN M383 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-204)

- iODN 2088 (TLRgrade™) (synthetic) (Inhibitory for mouse) (Prod. No. ALX-746-250)

- iODN (ttaggg)4 (TLRgrade™) (synthetic) (Inhibitory for human) (Prod. No. ALX-746-251)
Related Products
 
 
ALX-746-005 Revised 06-Oct-06
ODN 2216 (TLRgrade™) (synthetic)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Oligodeoxynucleotides [ODNs]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-746-005-T100   100 tests 155.00 USD Add To Cart
Product Specification
SEQUENCE: 5’-ggGGGACGATCGTCgggggg-3’
(lower case letters indicate phosphorothioate linkage).
MW: 6644 (ammonium salt)
SOURCE/HOST: Synthetic.
QUANTITY: 14.9nmol (~99µg). Sufficient for at least 100 cellular activation assays at 0.1-0.5µg/well when performed in a 200µl assay volume (i.e. 96 well microtiter plate).
PURITY DETAIL: Activity and endotoxin tested - TLRgrade™.
FORMULATION: Lyophilized. Sterile.
ENDOTOXIN CONTENT: <0.02 EU/µg (LAL test; BioWhittaker)
RECONSTITUTION: For a 100µM stock solution, dissolve the total vial content in 149µl endotoxin-free water (included) or PBS (to order seperately).
To obtain optimal dissolving we recommend the following procedure:
- Add 50% of the solvent and let dissolve for 10 min.
- Add remaining 50% of the solvent and mix thoroughly.
- Moderate warming may aid dissolving.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY:

Aqueous stock solution is stable for 1 day when stored at +4°C.
HANDLING: Protect from light. After reconstitution, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Description
CpG oligodeoxynucleotide (Type A) with mixed phosphodiester/phosphorothioate backbone. Specific ligand for human TLR9 (Toll-like receptor 9). For inactive control compound see ODN 2243 (Prod. No. ALX-746-205).
Product Specific Literature References
CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro: S. Rothenfusser, et al.; Blood 103, 2162 (2004) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION

Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).

Related Products:

- PBS (endotoxin-free) (Prod. No. ALX-505-007)

- ODN 2243 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-205)

- iODN (ttaggg)4 (TLRgrade™) (synthetic) (Inhibitory for human) (Prod. No. ALX-746-251)
Related Products
 
 
ALX-746-006 Revised 06-Oct-06
ODN 2006 (TLRgrade™) (synthetic)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Oligodeoxynucleotides [ODNs]
Ordering Information