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ALX-167-024
Revised 17-May-06
SN50
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
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ALX-167-024-C500
500 µg
125.00 USD
Product Specification
SEQUENCE:
H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
FORMULA:
C
129
H
230
N
36
O
29
S
MW:
2781.5
PEPTIDE CONTENT:
50-75%
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white solid.
FORMULATION:
Counter Ion:
Trifluoroacetate salt.
SOLUBILITY:
Soluble in distilled water, 100% ethanol or ethanol:water 1:1.
RECONSTITUTION:
Reconstitute in sterile distilled water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptides in solution have limited stability.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Inhibits translocation of the NF-κB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-κB nuclear translocation was 88% at 50µg/ml (18µM). In human monocytic THP-1 cells induced by LPS or TNF-α there was 85% inhibition at 100µg/ml.
For control peptide, see SN50M (Prod. No.
ALX-167-025
).
Product Specific Literature References
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence:
Y.Z. Lin, et al.; J. Biol. Chem.
270
, 14255 (1995)
Abstract
;
Full Text
p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism:
K.K. Meja, et al.; Br. J. Pharmacol.
131
, 1143 (2000)
Abstract
Nuclear factor-kappaB activates dual inhibition sites in the regulation of tumor necrosis factor-alpha-induced neutrophil apoptosis:
M. Niwa, et al.; Eur. J. Pharmacol
407
, 211 (2000)
Abstract
Activation of nuclear factor kappaB and induction of apoptosis by tumor necrosis factor-alpha in the mouse uterine epithelial WEG-1 cell line:
S. Pampfer, et al.; Biol. Reprod.
63
, 879 (2000)
Abstract
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells
:
Y. Dai, et al.; Blood
103
, 2761 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Nuclear localization sequence (NLS) aa 360-369 (AAVALLPAVLLALLAPVQRKRQKLMP) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF).
Further Categories Containing This Product:
Peptides
•
Nuclear Envelope & Nuclear Transport
ALX-167-025
Revised 17-May-06
SN50M Control Peptide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-167-025-C500
500 µg
125.00 USD
Product Specification
SEQUENCE:
H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Pro-Val-Gln-Arg-Asn-Gly-Gln-Lys-Leu-Met-Pro-OH
FORMULA:
C
123
H
215
N
33
O
30
S
MW:
2668.4
PEPTIDE CONTENT:
70-90%
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white solid.
FORMULATION:
Counter Ion:
Trifluoroacetate salt.
SOLUBILITY:
Soluble in water.
RECONSTITUTION:
Reconstitute in sterile distilled water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptides in solution have limited stability.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Inactive control peptide for SN50 (Prod. No.
ALX-167-024
). In mouse endothelial LE-II cells, induced with LPS, 50µg/ml SN50M had no measurable effect on NF-κB translocation. In human monocytic THP-1 cells induced by LPS or TNF-α there was slight inhibition at 100µg/ml.
Product Specific Literature References
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
:
Y.Z. Lin, et al.; J. Biol. Chem.
270
, 14255 (1995)
Abstract
;
Full Text
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells
:
Y. Dai, et al.; Blood
103
, 2761 (2004)
Abstract
Further Categories Containing This Product:
Peptides
•
Nuclear Envelope & Nuclear Transport
ALX-430-116
Revised 04-Mar-05
Sodium salicylate
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers:
Format:
Size:
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Quantity:
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ALX-430-116-G005
5 g
15.00 USD
Product Specification
FORMULA:
C
7
H
5
O
3
Na
MW:
160.1
CAS NUMBER:
54-21-7
MERCK INDEX:
14:
8332
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Specific Literature References
Inhibition of NF-kappa B by sodium salicylate and aspirin:
E. Kopp & S. Ghosh; Science
265
, 956 (1994)
Abstract
Neuroprotection by aspirin and sodium salicylate through blockade of NF- kappaB activation:
M. Grilli, et al.; Science
274
, 1383 (1996)
Abstract
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta:
M.J. Yin, et al.; Nature
396
, 77 (1998)
Abstract
The pleiotropic functions of aspirin: mechanisms of action:
A.R. Amin, et al.; Cell Mol. Life Sci.
56
, 305 (1999)
Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
ALX-306-022
Revised 07-Feb-05
D-erythro-Sphingosine chloride, N,N,N-Trimethyl-
SYNONYMS
N,N,N-Trimethyl-D-
erythro
-sphingosine chloride
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Ceramides / Cerebrosides / Sphingolipids / Related Products
Ordering Information
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Format:
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ALX-306-022-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
21
H
44
ClNO
2
MW:
378.0
SOURCE/HOST:
Synthetic.
APPEARANCE:
White crystalline solid.
SOLUBILITY:
Soluble in water, methanol or DMSO; slightly soluble in chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep under inert gas. Hygroscopic.
Product Description
Stable N-methylated derivative of sphingosine that exhibits antitumor and anti-inflammatory properties and inhibits platelet activating factor (PAF) activation and protein kinase C (PKC) activity. Inhibits IL-1β-induced NF-κB activation and cell surface expression of crucial selectins which promote adhesion of Le
x
- or sialosyl-Le
x
-expressing cells with platelets and endothelial cells.
Product Specific Literature References
Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine:
K. Handa, et al.; Biochemistry
30
, 11682 (1991)
Abstract
Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line:
H. Okoshi, et al.; Cancer Res.
51
, 6019 (1991)
Abstract
Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils:
S. Kimura, et al.; Biochem. Pharmacol.
44
, 1585 (1992)
Abstract
Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III:
Y.S. Park, et al.; Cancer Res.
54
, 2213 (1994)
Abstract
N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells:
A. Masamune, et al.; FEBS Lett.
367
, 205 (1995)
Abstract
Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors:
T. Murohara, et al.; Circ. Res.
78
, 780 (1996)
Abstract
;
Full Text
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors)
•
PKC Inhibitors
•
Anti-inflammatory Agents Other Products
•
NF-kB Pathway Inhibitors
ALX-430-105
Revised 10-Dec-04
Sulindac
SYNONYMS
MK-231
(1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1
H
-indene-3-acetic acid
cis
-5-Fluoro-2-methyl-1-[
p
-(methylsulfinyl)benzylidene]-indene-3-acetic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers:
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ALX-430-105-G001
1 g
10.00 USD
Product Specification
FORMULA:
C
20
H
17
FO
3
S
MW:
356.4
CAS NUMBER:
38194-50-2
MERCK INDEX:
14:
8982
RTECS:
NK8226000
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or aqueous bases.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Inhibits the NF-κB pathway. Non-steroidal anti-inflammatory drug. Reduces the level and activity of several cyclin-dependent kinases (CDKs) and induces apoptosis. For the active metabolite sulindac sulfide see Prod. No.
ALX-430-106
.
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
•
Apoptosis Inducers & Inhibitors Other Products
•
COX Inhibitors
ALX-430-106
Revised 31-Aug-04
Sulindac sulfide
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-430-106-M005
5 mg
32.00 USD
ALX-430-106-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
20
H
17
FO
2
S
MW:
340.4
CAS NUMBER:
32004-67-4
PURITY:
≥98%
APPEARANCE:
Yellow-orange solid.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Active metabolite of sulindac (Prod. Nr.
ALX-430-105
). NF-κB inhibitor. Induces apoptosis. Inhibits Ras signaling. Also inhibits cyclooxygenase (COX).
Product Specific Literature References
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis
:
G.A. Piazza, et al.; Cancer Res.
55
, 3110 (1995)
Abstract
Sulindac sulfide inhibits Ras signaling
:
C. Herrmann, et al.; Oncogene
17
, 1769 (1998)
Abstract
Sulindac inhibits activation of the NF-kappaB pathway
:
Y. Yamamoto, et al.; J. Biol. Chem.
274
, 27307 (1999)
Abstract
;
Full Text
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
•
COX Inhibitors
•
Apoptosis Inducers & Inhibitors Other Products
ALX-430-107
Revised 20-Aug-08
Sulindac sulfone
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-430-107-M005
5 mg
30.00 USD
ALX-430-107-M050
50 mg
90.00 USD
Product Specification
FORMULA:
C
20
H
17
FO
4
S
MW:
372.4
CAS NUMBER:
59864-04-9
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol (warm).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Metabolite of sulindac (Prod. No.
ALX-430-105
).
Product Specific Literature References
Sulindac inhibits activation of the NF-kappaB pathway:
Y. Yamamoto, et al.; J. Biol. Chem.
274
, 27307 (1999)
Abstract
;
Full Text
Further Categories Containing This Product:
COX Inhibitors
•
NF-kB Pathway Inhibitors
ALX-350-261
Revised 07-Oct-08
Trichodion
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
Ordering Information
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Format:
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ALX-350-261-C100
100 µg
85.00 USD
ALX-350-261-C500
500 µg
250.00 USD
Product Specification
FORMULA:
C
12
H
14
O
5
MW:
238.2
SOURCE/HOST:
Isolated from
Trichosporiella sp
.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Cytotoxic. Inhibits NF-κB (IC
50
=42-84µM), AP-1 (IC
50
=21µM) and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS ll) expression.
Product Specific Literature References
Trichodion, a new inhibitor of inflammatory signal transduction pathways from a Trichosporiella species:
G. Erkel; FEBS Lett.
477
, 219 (2000)
Abstract
;
Full Text
Trichodion, a new bioactive pyrone from a Trichosporiella species
:
G. Erkel, et al.; J. Antibiot. (Tokyo)
53
, 1401 (2000)
Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Natural Products - Nitric Oxide Pathway Modulators
•
NF-kB Pathway Inhibitors
•
COX Inhibitors
•
Other Natural Products for Inflammation Research
ALX-350-259
Revised 17-Dec-07
Triptolide
SYNONYMS
PG490
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Immunomodulators
Ordering Information
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Format:
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ALX-350-259-M001
1 mg
70.00 USD
ALX-350-259-M005
5 mg
280.00 USD
Product Specification
FORMULA:
C
20
H
24
O
6
MW:
360.4
CAS NUMBER:
38748-32-2
SOURCE/HOST:
Isolated from
Tripterygium wilfordii.
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Immunosuppressive agent with anti-inflammatory and antitumor properties. More effective in preventing T cell proliferation and interferon-γ production than FK506 (Prod. No.
ALX-380-008
). Induces apoptosis in T cells by activating DEVD cleaving caspases. Blocks TNF-α mediated induction of c-IAP1 and c-IAP2 and NF-κB activation.
Product Specific Literature References
Triptolide induces apoptotic death of T lymphocyte:
Y. Yang, et al.; Immunopharmacology
40
, 139 (1998)
Abstract
Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506:
M.A. Chan, et al.; Phytother. Res.
13
, 464 (1999)
Abstract
Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T- cells and NF-kappaB transcriptional activation:
D. Qiu, et al.; J. Biol. Chem.
274
, 13443 (1999)
Abstract
;
Full Text
PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells:
K.Y. Lee, et al.; J. Biol. Chem.
274
, 13451 (1999)
Abstract
;
Full Text
Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f::
D. Qiu & P.N. Kao; Drugs R. D.
4
, 1 (2003), (Review)
Abstract
Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells:
Y. Miyata, et al.; BBRC
336
, 1081 (2005)
Abstract
Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death:
S.D. Westerheide, et al.; J. Biol. Chem.
281
, 9616 (2006)
Abstract
Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells:
B.Z. Carter, et al.; Blood
108
, 630 (2006)
Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents
•
Natural Products - NF-kB Pathway Inhibitors
•
NF-kB Pathway Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - Antitumor Reagents
•
Antitumor Agents (Apoptosis Inducers)
ALX-350-153
Revised 28-Jul-08
Withaferin A
SYNONYMS
5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-153-M001
1 mg
60.00 USD
ALX-350-153-M005
5 mg
240.00 USD
Product Specification
FORMULA:
C
28
H
38
O
6
MW:
470.6
CAS NUMBER:
5119-48-2
MERCK INDEX:
14:
10048
RTECS:
KE7288500
SOURCE/HOST:
Isolated from
Withania somnifera
.
PURITY:
≥94% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (20 mg/ml), methanol (10 mg/ml) or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
MAY BE MUTAGENIC. MAY BE CARCINOGENIC. HARMFUL.
