ALEXIS Biochemicals: Polyclonal Antibody to ABIN-2

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ALX-430-064

Revised 15-Sep-08

Auranofin
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Lipoxygenases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-064-M025		25 mg	35.00 USD
ALX-430-064-M100		100 mg	68.00 USD

Product Specification

FORMULA:	C₂₀H₃₄AuO₉PS
MW:	678.5
CAS NUMBER:	34031-32-8
MERCK INDEX:	14: 878
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (5mg/ml) or 100% ethanol (4mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	Solutions are stable for up to 3 months when stored at -20 °C.
HAZARD:	TOXIC.

Product Description

Gold derivative in clinical use as an anti-arthritic. Acts as an inhibitor of several leukocyte activation pathways. Inhibits release of inflammatory mediators from human macrophages, pulmonary mast cell and basophils. Also inhibits human neutrophil 5-lipoxygenase. Efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions, potentially referable to its inhibition of mitochondrial thioredoxin reductase.

Product Specific Literature References

Antiarthritic gold compounds effectively quench electronically excited singlet oxygen: E.J. Corey, et al.; Science 236, 68 (1987) Abstract
Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin: M. Columbo, et al.; Biochem. Pharmacol. 39, 285 (1990) Abstract
Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils: W.H. Betts, et al.; Biochem. Pharmacol. 39, 1233 (1990) Abstract
Auranofin inhibits the activation pathways of polymorphonuclear leukocytes at multiple sites: R. Rudkowski, et al.; Biochem. Pharmacol. 41, 1921 (1991) Abstract
Induction of mitochondrial permeability transition by auranofin, a Gold(I)-phosphine derivative: M.P. Rigobello, et al.; Br. J. Pharmacol. 136, 1162 (2002) Abstract

General Literature References

Auranofin: W.F. Kean, et al.; Br. J. Theumatol. 36, 560 (1997), (Review) Abstract; Full Text

Further Categories Containing This Product:

MPTP [Mitochondrial Transition Pore] / Related Products • TLRs Other Products • Anti-inflammatory Agents Other Products

ALX-804-137

Revised 07-Dec-05

Monoclonal Antibody to A20 (human) (8E8.38)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLRs Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-137-C050		50 µg	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	8E8.38
ISOTYPE:	Mouse IgG1
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Zinc finger domain corresponding to aa 375-537 of human A20.
SPECIFICITY:	Recognizes human A20.
APPLICATION:	Western Blot (1:1'000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

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Product Description

A20 is a zinc finger protein that renders cells resistant to apoptosis. A20-deficient mice develop severe inflammation and are hyper-responsive to LPS. S.M. O'Reilly & P.N. Moynagh have shown that full length A20 inhibits activation of NF-kB and AP-1 by TLR4 [1]. A20 associates with A20-binding inhibitor of NF-kB (ABIN)-1 and -2 [2-4], which interfere with NF-kB activation upstream of the IKK complex.

Product Specific Literature References

A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome: F.S. Zetoune, et al.; Cytokine 15, 282 (2001) Abstract

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

[1] Regulation of Toll-like receptor 4 signalling by A20 zinc finger protein: S.M. O'Reilly and P.N. Moynagh; Biochem. Biophys. Res. Commun. 3303, 586 (2003) Abstract
[2] The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN: K. Heyninck, et al.; J. Cell Biol. 145, 1471 (1999) Abstract; Full Text
[3] Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2: S. Van Huffel, et al.; J Biol Chem 276, 30216 (2001) Abstract; Full Text
[4] Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1: K. Heyninck, et al.; FEBS Lett. 536, 135 (2003) Abstract

Further Categories Containing This Product:

NF-kB Pathway Other Products • Monoclonal Antibodies • Cell Death / Apoptosis / Autophagy Other Products

ALX-210-370

Revised 07-Aug-06

Polyclonal Antibody to ABIN-2
SYNONYMS	anti-A20-Binding Inhibitor of NF-κB 2 PAb
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	NF-kB Pathway Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-370-C100		100 µg	267.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
CONCENTRATION:	0.5mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptides corresponding to human ABIN-2 (A20-binding inhibitor of NF-κB 2).
SPECIFICITY:	Recognizes human and mouse ABIN-2. Detects a band of ~66kDa by Western blot.
APPLICATION:	Western Blot (0.5-2µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for 6 months when stored at +4°C.
HANDLING:	Avoid freeze/thaw cycles.

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Further Categories Containing This Product:

TLRs Other Products • Polyclonal Antibodies

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