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Obesity & Diabetes Other Products
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Items 19 of 19
ALX-270-404 Revised 24-Jan-06
Cilostamide
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SYNONYMS N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide
OCP 3689
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-404-M005   5 mg 50.00 USD Add To Cart
ALX-270-404-M025   25 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C20H26N2O3
MW: 342.4
CAS NUMBER: 68550-75-4
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and oxygen. Packaged under inert gas.

Product Description
Selective inhibitor (IC50=70nM) of phosphodiesterase 3 (PDE3). Reverses the established effects of leptin on food intake and body weight. Blocks the leptin-induced tyrosine phosphorylation of STAT3 at the hypothalamic level.
General Literature References
A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding.: A.Z. Zhao, et al.; Nat. Neurosci. 5, 727 (2002) Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products
 
 
ALX-270-466 Revised 14-Sep-07
Fluvastatin . sodium salt
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Statins / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-466-M010   10 mg 48.00 USD Add To Cart
ALX-270-466-M050   50 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C24H25FNO4 . Na
MW: 410.5 . 23.0
CAS NUMBER: 93957-54-1
MERCK INDEX: 14: 4218
RTECS: MJ9675050
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Off-white to light yellow solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Protect from light.
HAZARD: TOXIC. MAY BE TERATOGENIC.

Product Description
Anticholesterol agent. HMG-CoA reductase inhibitor and antioxidant.
Product Specific Literature References
Folate and carcinogenesis: an integrated scheme: S.W. Choi and J.B. Mason; J. Nutr. 130, 129 (2000) Abstract; Full Text
Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart: T. Obata, et al.; Biochim. Biophys. Acta 1536, 55 (2001) Abstract
Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes: A. Yamamoto, et al.; J. Pharm. Pharmacol. 53, 227 (2001) Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Obesity & Diabetes Other Products
 
 
ALX-201-421 Revised 14-Oct-08 New product
FTO (human) (recombinant) (His)
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SYNONYMS Fat Mass and Obesity-associated Protein (human) (recombinant) (His)
FATSO (human) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Obesity & Diabetes Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-421-C010   10 µg 230.00 USD Add To Cart
ALX-201-421-C050   50 µg 510.00 USD Add To Cart
Product Specification
SOURCE/HOST: Expressed in E. coli. The mature peptide of human FTO (aa 2-505) is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in 55mM TRIS, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
The FTO (fat mass and obesity-associated) gene is well conserved and found in a single copy in vertebrate species. It is suggested that the FTO protein plays a role in fat cell lipolysis, which may be important in explaining why the FTO gene (and FTO gene variants) is implicated in body weight regulation.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9C0B1: FTO (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity: T.M. Frayling, et al.; Science 316, 889 (2007) Abstract
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase: T. Gerken, et al.; Science 318, 1469 (2007) Abstract
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis: K. Wahlen, et al.; J. Lipid Res. 49, 607 (2008) Abstract
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain: R. Fredriksson, et al.; Endocrinology 149, 2062 (2008) Abstract
Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans: N. Klöting, et al.; Diabetologia 51, 641 (2008) Abstract
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes: J.A. Jacobsson, et al.; BBRC 368, 476 (2008) Abstract
Regulation of Fto/Ftm gene expression in mice and humans: G. Stratigopoulos, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1185 (2008) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Lipid Metabolism Other Products
 
 
ALX-201-436 Revised 14-Oct-08 New product
FTO (mouse) (recombinant) (His)
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SYNONYMS Fat Mass and Obesity-associated Protein (mouse) (recombinant) (His)
FATSO (mouse) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Obesity & Diabetes Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-436-C010   10 µg 240.00 USD Add To Cart
ALX-201-436-C050   50 µg 540.00 USD Add To Cart
Product Specification
SOURCE/HOST: Expressed in E. coli. The mature peptide of mouse FTO (aa 2-502) is fused at the N-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
The FTO (fat mass and obesity-associated) gene is well conserved and found in a single copy in vertebrate species. It is suggested that the FTO protein plays a role in fat cell lipolysis, which may be important in explaining why the FTO gene (and FTO gene variants) is implicated in body weight regulation.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8BGW1: FTO (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity: T.M. Frayling, et al.; Science 316, 889 (2007) Abstract
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase: T. Gerken, et al.; Science 318, 1469 (2007) Abstract
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis: K. Wahlen, et al.; J. Lipid. Res. 49, 607 (2007) Abstract
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain: R. Fredriksson, et al.; Endocrinology 149, 2062 (2008) Abstract
Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans: N. Klöting, et al.; Diabetologia 51, 641 (2008) Abstract
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes: J.A. Jacobsson, et al.; BBRC 368, 476 (2008) Abstract
Regulation of Fto/Ftm gene expression in mice and humans: G. Stratigopoulos, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1185 (2008) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Lipid Metabolism Other Products
 
 
ALX-201-202 Revised 22-Jan-08
Growth Hormone (20kDa) (human) (recombinant)
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SYNONYMS GH (20kDa) (human) (recombinant)
Somatotropin (20kDa) (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Growth Hormones / Related Products
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ALX-201-202-C100   100 µg 125.00 USD Add To Cart
Product Specification
MW: ~20kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 88mM mannitol, pH 7.4, containing 5mM phosphate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Obesity & Diabetes Other Products
 
 
ALX-201-201 Revised 20-May-05
Growth Hormone (human) (recombinant)
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SYNONYMS GH (human) (recombinant)
Somatotropin (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Growth Hormones / Related Products
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ALX-201-201-C100   100 µg 125.00 USD Add To Cart
Product Specification
MW: ~22.2kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 88mM mannitol, pH 7.4, containing 5mM phosphate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Obesity & Diabetes Other Products
 
 
ALX-430-023 Revised 11-Mar-05
KN-93
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SYNONYMS 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-023-M001   1 mg 84.00 USD Add To Cart
ALX-430-023-M005   5 mg 336.00 USD Add To Cart
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Product Specification
FORMULA: C26H29ClN2O4S
MW: 501.0
CAS NUMBER: 139298-40-1
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 5 years after receipt when stored at +4°C. DMSO stock solutions are stable for 3-4 months when stored at -20°C.
HANDLING: Protect from light.

Product Description
Selective inhibitor of rat brain Ca2+/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Induces G1 cell cycle arrest and apoptosis.
Product Specific Literature References
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991) Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993) Abstract
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993) Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN- 93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differentiation 6, 1063 (1995) Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-430-127 Revised 20-Feb-07
KN-93 (water soluble)
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SYNONYMS KN-93 . hydrogen phosphate
2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine . hydrogen phosphate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-127-M001   1 mg 90.00 USD Add To Cart
ALX-430-127-M005   5 mg 315.00 USD Add To Cart
Product Specification
FORMULA: C26H29ClN2O4S . H3PO4
MW: 501.0 . 98.0
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light. Hygroscopic.
HAZARD: IRRITANT.

Product Description
Selective inhibitor of rat brain Ca2+/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A (PKA) activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
Product Specific Literature References
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991) Abstract
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993) Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993) Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995) Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-270-343 Revised 30-May-07
3-O-Methyl-N-acetyl-D-glucosamine
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SYNONYMS 3-OMe-GlcNAc
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Carbohydrates
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ALX-270-343-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C9H17NO6
MW: 235.2
CAS NUMBER: 94825-74-8
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or water (10mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Inhibitor of N-acetylglucosamine kinase (Ki=17µM) and N-acetylmannosamine kinase (Ki=80µM). It has been found that 3-OMe-GlcNAc potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine.
Product Specific Literature References
Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro: R. Zeitler, et al.; Eur. J. Biochem. 204, 1165 (1992) Abstract
Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver: I. Miwa, et al.; Enzyme Protein 48, 135 (1994) Abstract
Further Categories Containing This Product:
N-Acetylneuraminic Acid / Derivatives • Obesity & Diabetes Other Products
 
 
ALX-801-035 Revised 08-Jan-07
Monoclonal Antibody to BSEP (human) (USal-hBSEP-McAb-1)
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SYNONYMS anti-Bile Salt Export Pump (human) MAb (USal-hBSEP-McAb-1)
anti-SPGP (human) MAb (USal-hBSEP-McAb-1)
anti-Sister of P-glycoprotein (human) MAb (USal-hBSEP-McAb-1)
anti-ABCB11 (human) MAb (USal-hBSEP-McAb-1)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Obesity & Diabetes Other Products
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ALX-801-035-C100   100 µg 285.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: USal-hBSEP-McAb-1