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ALX-430-063
Revised 10-Oct-07
Anthralin
SYNONYMS
Dithranol
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes Other Products
Ordering Information
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ALX-430-063-G001
1 g
25.00 USD
Product Specification
FORMULA:
C
14
H
10
O
3
MW:
226.2
CAS NUMBER:
1143-38-0
MERCK INDEX:
14:
684
RTECS:
CB8927000
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
MAY BE MUTAGENIC. IRRITANT.
Product Description
Leukotriene biosynthesis inhibitor. Inhibits LTB
4
ω-oxidation.
Product Specific Literature References
Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-omega oxidation by human neutrophils:
J.M. Schröder; J. Invest. Dermatol.
87
, 624 (1986)
Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Cancer Other Products
ALX-385-022
Revised 07-Oct-08
Baicalein
SYNONYMS
5,6,7-Trihydroxyflavone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavones
Ordering Information
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ALX-385-022-M005
5 mg
25.00 USD
ALX-385-022-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
15
H
10
O
5
MW:
270.2
CAS NUMBER:
491-67-8
MERCK INDEX:
14:
942
PURITY:
≥97%
APPEARANCE:
Yellow to yellow-green crystalline powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol; almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
Product Description
Inhibitor of 12-lipoxygenase, leukotriene biosynthesis and the release of lysosomal enzymes. Inhibits cellular Ca
2+
uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.
Product Specific Literature References
Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells:
J.L. Nadler, et al.; J. Clin. Invest.
80
, 1763 (1987)
Abstract
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone:
K. Ono, et al.; BBRC
160
, 982 (1989)
Abstract
Biliary excretion of metabolites of baicalin and baicalein in rats:
K. Abe, et al.; Chem. Pharm. Bull.
38
, 209 (1990)
Abstract
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells:
H.C. Huang, et al.; Eur. J. Pharmacol.
268
, 73 (1994)
Abstract
Protective effects of baicalein against cell damage by reactive oxygen species:
D. Gao, et al.; Chem. Pharm. Bull. (Tokyo)
46
, 1383 (1998)
Abstract
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules
:
S.L. Hsu, et al.; Eur. J. Pharmacol.
425
, 165 (2001)
Abstract
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes:
Y.C. Shen, et al.; Eur. J. Pharmacol.
465
, 171 (2003)
Abstract
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells:
H.Z. Lee, et al.; Anticancer Res.
25
, 959 (2005)
Abstract
Biological properties of baicalein in cardiovascular system:
Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord.
5
, 177 (2005), (Review)
Abstract
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression:
H.Y. Lin, et al.; Biochim. Biophys. Acta
1773
, 1073 (2007)
Abstract
Further Categories Containing This Product:
Leukotrienes Other Products
•
Tyrosine Kinase Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
Natural Products for Angiogenesis Research
•
Lipoxygenases / Related Products
•
Natural Products - Protein Kinase Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - Antioxidants
•
Natural Products - Antiviral / anti-HIV Agents
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Natural Products for Cell Cycle Research
ALX-270-090
Revised 14-May-03
Dapsone
SYNONYMS
4,4'-Diaminodiphenyl sulfone
DDS
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes Other Products
Ordering Information
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ALX-270-090-G001
1 g
10.00 USD
ALX-270-090-G005
5 g
20.00 USD
Product Specification
FORMULA:
C
12
H
12
N
2
O
2
S
MW:
248.3
CAS NUMBER:
80-08-0
MERCK INDEX:
14:
2822
PURITY:
≥96%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
TOXIC.
Product Description
Leukotriene B
4
(LTB
4
)
antagonist. Inhibits LTB
4
induced lysozyme release.
Product Specific Literature References
Dapsone inhibits LTB4 binding and bioresponse at the cellular and physiologic levels:
B.L. Maloff, et al.; Eur. J. Pharmacol.
158
, 85 (1988)
Abstract
ALX-340-026
Revised 16-Jun-06
LY-171,883
SYNONYMS
1-[2-Hydroxy-3-propyl-4-[4-(1
H
-tetrazol-5-yl)butoxy]phenyl]ethanone
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antagonists
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ALX-340-026-M010
10 mg
68.00 USD
Product Specification
FORMULA:
C
16
H
22
N
4
O
3
MW:
318.4
CAS NUMBER:
88107-10-2
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol, DMSO or dimethyl formamide. Also soluble in 0.5M aqueous sodium bicarbonate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Organic stock solutions are stable for at least six months when stored at –20°C.
Product Description
Competitive leukotriene D
4
(LTD
4
) antagonist. Has also been shown to bind to the γ-isofom of the peroxisome proliferator activated receptor (PPARγ).
Product Specific Literature References
LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5- yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist:
J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther.
233
, 148 (1985)
Abstract
Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit:
A. Sala, et al.; Br. J. Pharmacol.
110
, 1206 (1993)
Abstract
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid- activated transcription factor:
P. Tontonoz, et al.; Cell
79
, 1147 (1994)
Abstract
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma:
B.M. Forman, et al.; Cell
83
, 803 (1995)
Abstract
Further Categories Containing This Product:
Leukotrienes Other Products
ALX-340-021
Revised 04-Jun-08
MK-571 . sodium salt
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes Other Products
Ordering Information
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Size:
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ALX-340-021-M005
5 mg
45.00 USD
ALX-340-021-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
26
H
26
ClN
2
O
3
S
2
. Na
MW:
514.1 . 23.0
CAS NUMBER:
115104-28-4
PURITY:
≥97% (HPLC)
APPEARANCE:
Off-white to light yellow solid.
SOLUBILITY:
Soluble in water (20mg/ml), aqueous buffers, 100% ethanol (10mg/ml) or DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Aqueous stock solutions may be stable for more than 24 hours but we recommend making a fresh preparation before use.
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Leukotriene LTD4 receptor antagonist that potently inhibits MRP1.
Product Specific Literature References
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance
:
V. Gekeler, et al.; BBRC
208
, 345 (1995)
Abstract
Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide
:
L. Vernhet, et al.; Biochem. Pharmacol.
61
, 1387 (2001)
Abstract
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic
:
J. Liu, et al.; Mol. Pharmacol.
60
, 302 (2001)
Abstract
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?
:
K. Jones, et al.; Aids
15
, 1353 (2001)
Abstract
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells
:
U. Stein, et al.; Int. J. Cancer
97
, 751 (2002)
Abstract
Further Categories Containing This Product:
MDR Inhibitors
ALX-270-360
Revised 21-May-08
Tryptanthrin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products for Inflammation Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-360-M001
1 mg
50.00 USD
ALX-270-360-M005
5 mg
200.00 USD
Product Specification
FORMULA:
C
15
H
8
N
2
O
2
MW:
248.2
CAS NUMBER:
13220-57-0
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (
1
H-NMR, HPLC)
APPEARANCE:
Yellow needles.
SOLUBILITY:
Soluble in DMSO (8mg/ml) or methanol (0.3mg/ml); sparingly soluble in water (2.5µg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at +4°C in the dark. Stock solutions made in DMSO must be stored in the dark no longer than one month.
HANDLING:
Protect from light and moisture.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR, IR, MS and UV.
Product Description
Potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Selective inhibitor of cyclooxygenase 2 (COX-2). Inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Inhibits the production of IFN-γ and IL-2 after stimulation of Peyer’s patch lymphocytes with
staphylococcal
enterotoxin B (SEB). Inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin (Prod. No.
ALX-380-042
) resistance on breast cancer cells.
Product Specific Literature References
H. Danz, et al.; Arch. Pharm. Suppl. I
333
, 11 (2000)
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria:
H. Danz, et al.; Planta Med.
67
, 411 (2001)
Abstract
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis:
H. Danz, et al.; Planta Med.
68
, 875 (2002)
Abstract
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages:
T. Ishihara, et al.; Eur. J. Pharmacol.
407
, 197 (2000)
Abstract
Tryptanthrin inhibits interferon-gamma production by Peyer’s patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin
:
Y. Takei, et al.; Biol. Pharm. Bull.
26
, 365 (2003)
Abstract
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells:
S.T. Yu, et al.; BBRC
358
, 79 (2007)
Abstract
General Information
Tryptanthrin occurs as a natural product in various plants, including
Isatis tinctoria, I. indigotica, Polygonum tinctorium, Couroupita guianensis, Wrightia tinctoria
and
Calanthe discolor.
Further Categories Containing This Product:
Leukotrienes Other Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
MDR Inhibitors
•
Prostaglandins Other Products
•
P-glycoprotein [Pgp] / Related Products
•
Natural Products - Nitric Oxide Pathway Modulators
•
COX Inhibitors
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