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Prothymosin alpha
You are here: Product Lines > Cell Death / Apoptosis / Autophagy > Mitochondrial Pathway > Apoptosome/Related Products > Prothymosin alpha
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ALX-420-031 Revised 11-Jun-04
PETCM
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SYNONYMS α-(Trichloromethyl)-4-pyridineethanol
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-031-M010   10 mg 30.00 USD Add To Cart
ALX-420-031-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C8H8Cl3NO
MW: 240.5
CAS NUMBER: 10129-56-3
PURITY: ≥95%
APPEARANCE: White to brownish powder.
SOLUBILITY: Soluble in dimethyl formamide, DMSO or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. IRRITANT.
MELTINGPOINT: 164°C

Product Description
Activator of caspase-3 in cell extracts. Relieves prothymosin α inhibition and promotes apoptosome formation at a physiological concentration of deoxyadenosine triphosphate.
Product Specific Literature References
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway: X. Jiang, et al.; Science 299, 223 (2003) Abstract
Related Products
Further Categories Containing This Product:
Caspases Other Products
 
 
ALX-201-125 Revised 10-Feb-05
Prothymosin α (1-99) (human) (recombinant)
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SYNONYMS ProTα (1-99) (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-125-C050   50 µg 210.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Corresponding to the caspase-3 cleavage product of prothymosin α (ProTα) isolated from apoptotic human cells (no affinity-tags, no added additional (linker) sequences). Purified from overproducing bacterial strains by a phenol extraction procedure, DEAE chromatography, and ethanol precipitation [1].
CONCENTRATION: 1.5mg/ml
PURITY: ≥90%
FORMULATION: Liquid. 50µg dissolved in sterile water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
[1] Overproduction in Escherichia coli, purification and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Eur. J. Biochem. 231, 639 (1995) Abstract
[2] Sensing prothymosin alpha origin, mutations and conformation with monoclonal antibodies: E.A. Sukhacheva, et al.; J. Immunol. Methods 266, 185 (2002) Abstract
[3] Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Exp. Cell Res. 284, 209 (2003) Abstract
[4] Cytochrome c is transformed from anti- to pro-oxidant when interacting with truncated oncoprotein prothymosin alpha: O.V. Markova, et al.; Biochim. Biophys. Acta 1557, 109 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION The exact length of the human protein is 109 aa corresponding to the NCBl data base entries AAH34921 and TNHUA. The N-terminal M is absent in the mature protein (otherwise, it would be 110). ProTα is acetylated at the N-terminal S. MALDI-MS data for the recombinant ProTα isolated from bacteria show that the protein is partially acetylated.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-201-126 Revised 10-Feb-05
Prothymosin α (1-109) (human) (recombinant)
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SYNONYMS ProTα (1-109) (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-126-C050   50 µg 210.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Native sequence representing mature prothymosin α (ProTα) isolated from human cells (no affinity-tags, no additional added (linker) sequences). Purified from overproducing bacterial strains by a phenol extraction procedure, DEAE chromatography, and ethanol precipitation [1].
CONCENTRATION: 2.5mg/ml
PURITY: ≥90%
FORMULATION: Liquid. 50µg dissolved in sterile water.
BIOLOGICAL ACTIVITY: Stimulates mouse thymocytes comparable to native ProTα [1].
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
[1] Overproduction in Escherichia coli, purification and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Eur. J. Biochem. 231, 639 (2003) Abstract
[2] Sensing prothymosin alpha origin, mutations and conformation with monoclonal antibodies: E.A. Sukhacheva, et al.; J. Immunol. Methods 266, 185 (2002) Abstract
[3] Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha: A.G. Evstafieva, et al.; J. Exp. Cell Res. 284, 209 (2003) Abstract
[4] Cytochrome c is transformed from anti- to pro-oxidant when interacting with truncated oncoprotein prothymosin alpha: O.V. Markova, et al.; Biochim. Biophys. Acta 1557, 109 (2003) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION The exact length of the human protein is 109 aa corresponding to the NCBl data base entries AAH34921 and TNHUA. The N-terminal M is absent in the mature protein (otherwise, it would be 110). ProTα is acetylated at the N-terminal S. MALDI-MS data for the recombinant ProTα isolated from bacteria show that the protein is partially acetylated.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-804-486 Revised 31-Oct-06
Monoclonal Antibody to Prothymosin α (NT) (2F11)
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SYNONYMS anti-ProTα MAb (NT) (2F11)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-486-C100   100 µg 200.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: 2F11
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Protein G-purified antibody in 0.1M TRIS-glycine buffer, pH 7.7, containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human ProTα (prothymosin α) (aa 1-99).
SPECIFICITY: Recognizes human, mouse, rat and bovine ProTα. Recognized epitope includes aa 1-31 of human ProTα. Does not cross-react with human parathymosin.
APPLICATION: Immunocytochemistry (excellent) (1:300)
Immunoprecipitation (1µl MAb/10µl cell lysate)
Western Blot (1:2'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
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Product Specific Literature References
Overproduction in Escherichia coli, purification and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Eur. J. Biochem. 231, 639 (1995) Abstract
Sensing prothymosin alpha origin, mutations and conformation with monoclonal antibodies: E.A. Sukhacheva, et al.; J. Immunol. Methods 266, 185 (2002) Abstract
Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Exp. Cell. Res. 284, 209 (2003) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-487 Revised 31-Oct-06
Monoclonal Antibody to Prothymosin α (human ) (4F4)
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SYNONYMS anti-ProTα MAb (human) (4F4)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-487-C100   100 µg 200.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 4F4
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Protein G-puified antibody in 0.1M TRIS-glycine buffer, pH 7.7, containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human full length ProTα (prothymosin α).
SPECIFICITY: Recognizes human ProTα. Recognized epitope includes aa 52-89 of human ProTα. Does not cross-react with human parathymosin.
APPLICATION: Immunocytochemistry (1:300)
Immunoprecipitation
Western Blot (excellent; 1: 2'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Specific Literature References
Overproduction in Escherichia coli, purification and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Eur. J. Biochem. 231, 639 (1995) Abstract
Sensing prothymosin alpha origin, mutations and conformation with monoclonal antibodies: E.A. Sukhacheva, et al.; J. Immunol. Methods 266, 185 (2002) Abstract
Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha: A.G. Evstafieva, et al.; Exp. Cell Res. 284, 209 (2003) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
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