• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Eicosanoids / Related Products
You are here: Product Lines > Inflammation > Eicosanoids / Related Products
 
Toolbar - View Selection
 
 Items 20-40 of 83 Page 2 of 5 Select Page: << 1 2 3 4 5  >>  
ALX-270-099 Revised 02-Dec-04
Ethyl 3,4-dihydroxybenzylidenecyanoacetate
Add to Clipboard
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipoxygenases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-099-M025   25 mg 63.00 USD Add To Cart
Product Specification
FORMULA: C12H11NO4
MW: 233.2
CAS NUMBER: 132464-92-7
PURITY: ≥96%
SOLUBILITY: Soluble in DMSO and methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
12- and 15-lipoxygenase inhibitor.
Product Specific Literature References
Novel caffeic acid derivatives: extremely potent inhibitors of 12- lipoxygenase: H. Cho, et al.; J. Med. Chem. 34, 1503 (1991) Abstract
 
 
ALX-340-009 Revised 04-Feb-05
ETI
Add to Clipboard
SYNONYMS 5,8,11-Eicosatriynoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipoxygenases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-009-M001   1 mg 77.00 USD Add To Cart
ALX-340-009-M005   5 mg 346.00 USD Add To Cart
Product Specification
FORMULA: C20H28O2
MW: 300.4
CAS NUMBER: 13488-22-7
PURITY: ≥99%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in ethanol, DMSO or DMF.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from oxygen and light.

Product Description
Inhibitor of 5- and 12-lipoxygenase. No activity versus cyclooxygenase (COX) in whole cells. Also inhibits hepatic glutathione S-transferase and leukotriene C4 biosynthesis.
Product Specific Literature References
Selective inhibition of platelet n-8 lipoxygenase by 5,8,11- eicosatriynoic acid: S. Hammarström; Biochem. Biophys. Acta 487, 517 (1977) Abstract
Inhibition of leukotriene C and leukotriene D biosynthesis: L. Örning & S. Hammarström; J. Biol. Chem. 255, 8023 (1980) Abstract; Full Text
Inhibition of mammalian hepatic glutathione S-transferases by acetylenic fatty acids: K. Datta & A.P. Kulkarni; Toxicol. Lett. 73, 157 (1994) Abstract
 
 
ALX-340-010 Revised 28-Feb-07
ETYA
Add to Clipboard
SYNONYMS 5,8,11,14-Eicosatetraynoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipoxygenases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-010-M005   5 mg 40.00 USD Add To Cart
ALX-340-010-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C20H24O2
MW: 296.5
CAS NUMBER: 1191-85-1
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO, acetone or acetonitrile.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing the solutions for more than one day.
HANDLING: Protect from light and oxygen.
HAZARD: TOXIC.

Product Description
Inhibits arachidonic acid uptake. Inhibitor of lipoxygenases, cyclooxygenases (COX), phospholipase A2 and cytochrome P450. Modulates Ca2+ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells. PPAR agonist.
Product Specific Literature References
Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthetase: D.T. Downing, et al.; Biochim. Biophys. Acta 280, 343 (1972) Abstract
The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism: L.D. Tobias & J.G. Hamilton; Lipids 14, 181 (1979) Abstract
An inhibitor of arachidonic acid metabolism stimulates luteinizing hormone (LH) release from cultured pituitary cells: P.M. Conn, et al.; Prostaglandins 19, 873 (1980) Abstract
Evidence for inhibition of leukotriene A4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes: G.M. Bokoch & P.W. Reed; J. Biol. Chem. 256, 4156 (1981) Abstract; Full Text
Phospholipase A2-induced rat mast cell secretion. Role of arachidonic acid metabolites: E.Y. Chi, et al.; Lab. Invest. 47, 579 (1982) Abstract
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets: J.R. Falck, et al.; BBRC 114, 743 (1983) Abstract
The mechanism of inactivation of lipoxygenases by acetylenic fatty acids: H. Kühn, et al.; Eur. J. Biochem. 139, 577 (1984) Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostagl. Leukotr. Med. 13, 53 (1984) Abstract
Incorporation of 5,8,11,14-eicosatetraynoic acid (ETYA) into cell lipids: competition with arachidonic acid for esterification: A.S. Taylor, et al.; Prostaglandins 29, 449 (1985) Abstract
Inhibition of U937 eicosanoid and DNA synthesis by 5,8,11,14- eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism and its partial reversal by leukotriene C4: F. Ondrey, et al.; Cancer Res. 49, 1138 (1989) Abstract
Effects of 5,8,11,14-eicosatetraynoic acid on thapsigargin-induced calcium entry, and intracellular pH in thyroid FRTL-5 cells: E. Ekokoski & K. Tornquist; Biochim. Biophys. Acta 1223, 274 (1994) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Cytochrome P450 [CYP450] / Related Products • PPAR Agonists • Ca2+ Modulators • COX Inhibitors
 
 
ALX-420-043 Revised 03-Sep-08
FTY720
Add to Clipboard
SYNONYMS 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl
Fingolimod . HCl
PRODUCT LINE Immunology
PRODUCT CATEGORY Immunomodulators Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-043-M001   1 mg 40.00 USD Add To Cart
ALX-420-043-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C19H33NO2 . HCl
MW: 307.5 . 36.5
CAS NUMBER: 162359-56-0
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: 20mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing aqueous solutions for more than one day.

Product Description
Analog of myriocin (Prod. No. ALX-350-274). Novel immune modulator that alters migration and homing of lymphocytes. Acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Also inhibits cytosolic phospholipase A2 independently of sphingosine 1-phosphate receptors.
Product Specific Literature References
The immune modulator FTY720 targets sphingosine 1-phosphate receptors: V. Brinkmann, et al.; J. Biol. Chem. 277, 21453 (2002) Abstract; Full Text
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109, 1077 (2007) Abstract
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia: P. Neviani, et al.; J. Clin. Invest. 117, 2408 (2007) Abstract; Full Text
Related Products
Further Categories Containing This Product:
PLA2 Inhibitors
 
 
ALX-270-120 Revised 30-Jul-08
Furegrelate sodium
Add to Clipboard
SYNONYMS U-63557A
Sodium furegrelate
PRODUCT LINE Inflammation
PRODUCT CATEGORY Thromboxanes / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-120-M010   10 mg 90.00 USD Add To Cart
ALX-270-120-M050   50 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C15H10NO3 . Na
MW: 252.2 . 23.0
CAS NUMBER: 85666-17-7
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in water (15mg/ml), methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at -20°C. Before use, prepare a stock solution by dissolving the product in water. Stock solutions will be stable for at least 1 month if stored at 0°C in an oxygen-free environment.
IDENTITY: Identity determined by MS, 1H-NMR and 13C-NMR.

Product Description
Potent and selective orally active inhibitor of thromboxane A2 synthase.
Product Specific Literature References
Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate: R.R. Gorman, et al.; Prostaglandins 26, 325 (1983) Abstract
Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl)benzofuran-2-carboxylic acids: R.A. Johnson, et al.; J. Med. Chem. 29, 1461 (1986) Abstract
Pharmacokinetics of furegrelate after oral administration to normal humans: D.B. Lakings, et al.; Pharm. Res. 6, 53 (1989) Abstract
Thromboxane synthase activity and platelet function after furegrelate administration in man: J.S. Mohrland, et al.; J. Clin. Pharmacol. 29, 53 (1989) Abstract
Multiple dose trial of the thromboxane synthase inhibitor furegrelate in normal subjects: J.S. Mohrland, et al.; Eur. J. Clin. Pharmacol. 38, 485 (1990) Abstract
 
 
ALX-300-140 Revised 08-Jul-08
1,2-bis(Heptanoylthio)glycerophosphocholine
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Lipid Signalling Pathways Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-300-140-M005   5 mg 215.00 USD Add To Cart
Product Specification
FORMULA: C22H44NO6PS2
MW: 513.7
CAS NUMBER: 89019-63-6
PURITY: ≥95%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: 50 mg/ml soluble in DMSO or dimethyl formamide; sparingly soluble in PBS, pH 7.2 (62μg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description
Substrate for the general assay of phospholipases, except Ca2+-dependent cytosolic phospholipase A2 (cPLA2). PLA2 hydrolyzes the sn-2 position of the phospholipid thiol groups. The released thiol can be estimated colorimetrically using Ellman's reagent (DTNB, Prod. No. ALX-400-034). For an assay kit for secretory PLA2 (sPLA2) based on this substrate see Prod. No. ALX-850-007. For a substrate for cPLA2 see Arachidonoyl Thio-PC (Prod. No. ALX-300-141).
Product Specific Literature References
Analysis of human synovial fluid phospholipase A2 on short chain phosphatidylcholine-mixed micelles: development of a spectrophotometric assay suitable for a microtiterplate reader: L.J. Reynolds, et al.; Anal. Biochem. 204, 190 (1992) Abstract
Thio-based phospholipase assay: L. Yu & E.A. Dennis; Meth. Enzymol. 197, 65 (1991) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. Avoid dissolving 1,2-bis(Heptanoylthio)glycerophosphocholine in basic solutions, since base treatment promotes hydrolysis of the thioester. Triton X-100 will enhance the solubility significantly. The critical micellar concentration of 1,2-bis(Heptanoylthio)glycerophosphocholine 0.17mM in 0.2M Tris-maleate buffer, pH 7.4.
Further Categories Containing This Product:
PLA2 Substrates
 
 
ALX-340-037 Revised 08-Jul-08
8(S)-HETE
Add to Clipboard
SYNONYMS 8-Hydroxy-[S-(E,Z,Z,Z)]-5,9,11,14-eicosatetraenoic acid
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Hydroxy, Hydroperoxy & Oxo Fatty Acids / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-037-C025   25 µg 165.00 USD Add To Cart
Product Specification
FORMULA: C20H32O3
MW: 320.5
CAS NUMBER: 98462-03-4
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na2CO3 (2mg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING: Protect from light and oxygen.

Product Description
Activator of PPARα. Activates mouse skin protein kinase C (PKC).
Product Specific Literature References
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin: M.A. Hughes & A.R. Brash; Biochim. Biophys. Acta 1081, 347 (1991) Abstract
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites: H.H. Lo, et al.; Lipids 29, 547 (1994) Abstract
Differential activation of peroxisome proliferator-activated receptors by eicosanoids: K. Yu, et al.; J. Biol. Chem. 270, 23975 (1995) Abstract; Full Text
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans: Y. Guan, et al.; Am. J. Physiol. 273, F1013 (1997) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists • PKC Activators
 
 
ALX-350-138 Revised 05-Dec-06
Hexaprenylhydroquinone
Add to Clipboard
SYNONYMS HPH
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antiviral / anti-HIV Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-138-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C36H54O2
MW: 518.8
CAS NUMBER: 119980-00-6
SOURCE/HOST: Isolated from Sarcotragus sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Potent inhibitor of HIV reverse transcriptase and cellular DNA polymerase. Inhibitor of CDC25A. Similar compounds have shown inhibitory effects on phospholipase A2.
Product Specific Literature References
Three new heptaprenylhydroquinone derivatives from the sponge Ircinia fasciculata: Y. Venkateswarlu and M. Venkata Rami Reddy; J. Nat. Prod. 57, 1286 (1994)
Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays: S. De Rosa, et al.; J. Nat. Prod. 57, 1711 (1994) Abstract
Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases: S. Loya, et al.; Biochem. J. 324, 721 (1997) Abstract; Full Text
Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A: I. Erdogan-Orhan, et al.; Nat. Prod. Res. 18, 1 (2004) Abstract
General Literature References
Effects of marine 2-polyprenyl-1,4-hydroquinones on phospholipase A2 activity and some inflammatory responses: B. Gil, et al.; Eur. J. Pharmacol. 285, 281 (1995) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Natural Products - DNA Replication Inhibitors • HIV / AIDS / Related Products
 
 
ALX-340-057 Revised 10-Jul-08
12(S)-HpETE
Add to Clipboard
SYNONYMS 12-(S)-Hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Eicosanoids Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-057-C025   25 µg 162.00 USD Add To Cart
ALX-340-057-C050   50 µg 308.00 USD Add To Cart
Product Specification
FORMULA: C20H32O4
MW: 336.5
CAS NUMBER: 71774-10-2
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na2CO3 (2mg/ml).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -80°C. Product is highly unstable in aqueous solution. We recommend using aqueous solutions within fifteen minutes.

Product Description
Endogenous TRPV1 agonist (Ki=0.35µM).
Product Specific Literature References
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances: S.W. Hwang, et al.; PNAS 97, 6155 (2000) Abstract
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia: J. Shin, et al.; PNAS 99, 10150 (2002) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Fos & Jun Proteins / Related Products • Endovanilloids
 
 
ALX-340-058 Revised 10-Jul-08
15(S)-HpETE
Add to Clipboard
SYNONYMS 15S-Hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Eicosanoids Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-058-C025   25 µg 41.00 USD Add To Cart
ALX-340-058-C050   50 µg 79.00 USD