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ALX-210-811
Revised 29-Nov-04
Polyclonal Antibody to Caspase-7
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-811-C100
100 µg
357.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
Pig
Monkey
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
FORMULATION:
Liquid. Affinity purified antibody in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 264-279 of human caspase-7.
SPECIFICITY:
Recognizes human, mouse, rat, hamster, monkey, rabbit, dog, pig and sheep caspase-7. Detects bands of ~34kDa (full length caspase-7) and ~10kDa (p10 subunit of the active form of caspase-7) by Western blot.
APPLICATION:
Western Blot (1-2µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-812
Revised 29-Nov-04
Polyclonal Antibody to Caspase-7
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-812-C100
100 µg
273.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
FORMULATION:
Liquid. Antibody in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 159-170 of human caspase-7.
SPECIFICITY:
Recognizes human, mouse and rat caspase-7. Detects bands of ~34kDa (full length caspase-7) and ~20kDa (processed caspase-7) by Western blot.
APPLICATION:
Western Blot (1-4µg/ml)
Optimal conditions must be determined individually.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-813
Revised 29-Nov-04
Polyclonal Antibody to Caspase-7 (active)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-813-C100
100 µg
371.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
FORMULATION:
Liquid. Affinity purified antibody in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide around the cleavage site of human caspase-7.
SPECIFICITY:
Recognizes human, mouse and rat active caspase-7 p20 subunit. Does not cross-react with procaspase-7 or other caspases.
APPLICATION:
Immunocytochemistry (5µg/ml)
Immunohistochemistry (10-20µg/ml)
Immunoprecipitation (10-20µg/ml)
Western Blot (1µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-013
Revised 29-Jun-05
Polyclonal Antibody to Caspase-7 (human)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-013-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human caspase-7 (large catalytic subunit).
SPECIFICITY:
Recognizes human caspase-7. Detects both procaspase-7 and the large subunit of active caspase-7.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile
:
P.W. Mesner Jr., et al.; J. Biol. Chem.
274
, 22635 (1999)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-815
Revised 24-May-07
Polyclonal Antibody to Caspase-9
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-815-C100
100 µg
371.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Pig
Monkey
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.2, containing 0.5% BSA, 0.01% thimerosal and 30% glycerol.
IMMUNOGEN:
Synthetic peptide corresponding to aa 287-306 of human caspase-9.
SPECIFICITY:
Recognizes human, mouse, rat, hamster, rabbit, pig, dog, monkey and bovine caspase-9. Detects procaspase-9 and a caspase-9 cleavage product by Western blot.
APPLICATION:
Western Blot (1-4µg/ml).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-816
Revised 29-Oct-07
Polyclonal Antibody to Caspase-9 (active)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-816-C100
100 µg
371.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 0.5% BSA and 0.02% thimerosal.
IMMUNOGEN:
Synthetic peptide around the cleavage site of human caspase-9.
SPECIFICITY:
Recognizes human and rat active caspase-9. Detects a band of ~37kDa by Western blot. Does not cross-react with procaspase-9.
APPLICATION:
Immunocytochemistry (10-20µg/ml)
Immunoprecipitation (10-20µg/ml)
Western Blot (0.5-1µg/ml)
Optimal conditions must be determined indiviually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-014
Revised 24-Mar-05
Polyclonal Antibody to Caspase-9 (Bur 49)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
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ALX-210-014-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Serum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human caspase-9 (catalytic subunit).
SPECIFICITY:
Recognizes human, mouse, rat and dog caspase-9. Detects both procaspase-9 and the 15kDa small subunit of activated caspase-9.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
:
S. Krajewski, et al.; PNAS
96
, 5752 (1999)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-015
Revised 24-Mar-05
Polyclonal Antibody to Caspase-9 (Bur 73)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-015-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 112-130 (R
112
PEIRKPEVLRPETPRPVD
130
) of human caspase-9.
SPECIFICITY:
Recognizes human, mouse, rat and dog caspase-9. Detects both procaspase-9 and the 35kDa large subunit of activated caspase-9. Detects endogenous protein by IHC and WB.
APPLICATION:
Immunocytochemistry (1:50)
Immunohistochemistry (paraffin sections (1:5'000)
Immunoprecipitation (1:150)
Western Blot (1:2'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia:
S. Krajewski, et al.; PNAS
96
, 5752 (1999)
Abstract
;
Full Text
Nuclear localization of procaspase-9 and processing by a caspase-3-like activity in mammary epithelial cells:
P.M. Ritter, et al.; Eur. J. Cell Biol.
79
, 358 (2000)
Abstract
Temporal and spatial profile of Bid cleavage after experimental traumatic brain injury:
G. Franz, et al.; J. Cereb. Blood Flow Metab.
22
, 951 (2002)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-838
Revised 20-Nov-06
Polyclonal Antibody to Caspase-9 (human)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-838-R100
100 µl
345.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human full-length caspase-9.
SPECIFICITY:
Recognizes human procaspase-9 and the p37/p35 cleavage products of activated caspase-9.
APPLICATION:
Immunoprecipitation
Western Blot
Recommended for the detection of endogenous caspase-9 activation.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-818
Revised 05-Mar-07
Polyclonal Antibody to Caspase-11
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-818-C100
100 µg
315.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.2, containing 0.5% BSA, 0.01% thimerosal and 30% glycerol
IMMUNOGEN:
Synthetic peptide corresponding to aa 202-217 of mouse caspase-11.
SPECIFICITY:
Recognizes mouse and rat caspase-11. Detects full length caspase-11 and cleavage fragments by Western blot.
APPLICATION:
Western Blot (1µg/ml).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-842
Revised 12-Apr-06
Polyclonal Antibody to Caspase-14 (mouse)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-842-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 165-185 (A
165
VLKNNPQSIP
TYTDTLHIYS
185
) of mouse caspase-14.
SPECIFICITY:
Recognizes mouse caspase-14.
APPLICATION:
Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-044
.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-260-159
Revised 03-Jun-08
Q-VD-OPH
SYNONYMS
Pan-Caspase Inhibitor (Fluoromethylketone)
N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-159-M003
3 mg
840.00 USD
Product Specification
FORMULA:
C
26
H
25
F
2
N
3
O
6
MW:
513.8
PURITY:
≥90% (HPLC)
SOLUBILITY:
Soluble in DMSO (10mM).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Hygroscopic. Keep under inert gas.
Product Description
Selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC
50
=25nm), caspase-1 (IC
50
=50nM), caspase-8 (IC
50
=100nM) and caspase-9 (IC
50
=430nM). Protects neurotoxin-insulted neurons from apoptotic death. Displays minimal
in vivo
toxicity. To reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated.
Product Specific Literature References
Caspase inhibition switches doxorubicin-induced apoptosis to senescence
:
A. Rebbaa, et al.; Oncogene
22
, 2805 (2003)
Abstract
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties
:
T.M. Caserta, et al.; Apoptosis
8
, 345 (2003)
Abstract
Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia
:
K. Patil & S.C. Sharma; Neuroreport
15
, 981 (2004)
Abstract
ALX-260-153
Revised 07-Nov-05
Z-AAD-CMK (Ready-to-Use)
