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Granzyme Substrates
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ALX-260-115 Revised 05-Apr-05
Ac-IEPD-AFC
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SYNONYMS Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-115-M005   5 mg 157.00 USD Add To Cart
ALX-260-115-M010   10 mg 295.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Ile-Glu-Pro-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA: C32H38F3N5O11
MW: 725.7
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8 and granzyme B.
General Information
BACKGROUND/TECHNICAL INFORMATION AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
Further Categories Containing This Product:
Granzyme Substrates
 
 
ALX-260-151 Revised 17-Jan-06
Ac-IEPD-AMC
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SYNONYMS Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-151-M001   1 mg 70.00 USD Add To Cart
ALX-260-151-M005   5 mg 210.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Ile-Glu-Pro-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA: C32H41N5O11
MW: 671.7
PEPTIDE CONTENT: 70-95%
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8 and granzyme B.
Product Specific Literature References
Definition and redesign of the extended substrate specificity of granzyme B: J.L. Harris, et al.; J. Biol. Chem. 273, 27364 (1998) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
Further Categories Containing This Product:
Granzyme Substrates
 
 
ALX-260-152 Revised 05-Apr-05
Ac-IEPD-pNA
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SYNONYMS Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-152-M001   1 mg 60.00 USD Add To Cart
ALX-260-152-M005   5 mg 180.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Ile-Glu-Pro-Asp-pNA (pNA=p-Nitroaniline)
FORMULA: C28H38N6O11
MW: 634.6
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Chromogenic substrate for caspase-8 and granzyme B.
Product Specific Literature References
Definition and redesign of the extended substrate specificity of granzyme B: J.L. Harris, et al.; J. Biol. Chem. 273, 27364 (1998) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION λmax of pNA is 400nm.
Further Categories Containing This Product:
Granzyme Substrates
 
 
ALX-260-110 Revised 05-Apr-05
Ac-IETD-AFC
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SYNONYMS Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-110-M005   5 mg 157.00 USD Add To Cart
ALX-260-110-M010   10 mg 295.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Ile-Glu-Thr-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA: C31H38F3N5O12
MW: 729.7
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy: D.J. Granville, et al.; FEBS Lett. 437, 5 (1998) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
Further Categories Containing This Product:
Granzyme Substrates
 
 
ALX-260-042 Revised 02-Oct-07
Ac-IETD-AMC
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SYNONYMS Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-042-M001   1 mg 42.00 USD Add To Cart
ALX-260-042-M005   5 mg 163.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA: C31H41N5O12
MW: 675.7
PEPTIDE CONTENT: 70-90%
PURITY: ≥98% (HPLC)
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Fluorogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
Further Categories Containing This Product:
Granzyme Substrates
 
 
ALX-260-045 Revised 15-Dec-05
Ac-IETD-pNA
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SYNONYMS Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-045-M001   1 mg 22.00 USD Add To Cart
ALX-260-045-M005   5 mg 83.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Ile-Glu-Thr-Asp-pNA (pNA=p-Nitroaniline)
FORMULA: C27H38N6O12
MW: 638.6
PEPTIDE CONTENT: 70-90%
PURITY: 98% (HPLC)
APPEARANCE: White powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO. Dilute with buffer, pH 7.0-7.5.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Chromogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997) Abstract; Full Text
Apoptosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes: C.A. Belmokhtar, et al.; J. Biol. Chem. 278, 29571 (2003) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION λmax of pNA is 400nm.
Further Categories Containing This Product:
Granzyme Substrates
 
 
ALX-260-050 Revised 18-Jan-05
BAADT
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SYNONYMS Granzyme B Substrate (Chromogenic)
Boc-AAD-SBzl
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-050-M001   1 mg 110.00 USD Add To Cart
ALX-260-050-M005   5 mg 410.00 USD Add To Cart
Product Specification
SEQUENCE: Boc-Ala-Ala-Asp-SBzl
FORMULA: C22H31N3O7S
MW: 481.6
PURITY: ≥96% (HPLC).
Single spot (TLC)
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.
Product Description
Chromogenic substrate for granzyme B. λmax is at 405nm.
Product Specific Literature References
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins: S. Odake, et al.; Biochemistry 30, 2217 (1991) Abstract
Further Categories Containing This Product:
Granzyme Substrates
 
 
ALX-260-044 Revised 05-Apr-05
Z-IETD-pNA
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SYNONYMS Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-044-M001   1 mg 22.00 USD Add To Cart
ALX-260-044-M005   5 mg 83.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Ile-Glu-Thr-Asp-pNA (pNA = p-Nitroaniline)
FORMULA: C33H42N6O13
MW: 730.7
PEPTIDE CONTENT: 70-90%
PURITY: ≥99% (HPLC)
APPEARANCE: White powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8 and granzyme B with increased cell permeability. Also substrate for caspase-10.
General Information
BACKGROUND/TECHNICAL INFORMATION λmax of pNA is 400nm.
Further Categories Containing This Product:
Granzyme Substrates
 
 
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