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Inflammation
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ALX-804-494 Revised 08-Jul-08
Monoclonal Antibody to Caspase-11 (mouse) (8A5)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-494-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
CLONE: 8A5
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: p20 fragment of mouse caspase-11.
SPECIFICITY: Recognizes mouse and rat caspase-11 (epitope in the p20 fragment). Detects two bands of ~38kDa and ~43kDa by Western blot.
APPLICATION: Flow Cytometry, Western blot.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
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General Information
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. Human caspase-4, thought to be the homolog of mouse caspase-11, may be an effective therapeutic target for treatment of septic shock.
General Literature References
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway: J. Hur, et al.; FEBS Lett. 507, 157 (2001) Abstract
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response: S.J. Kang, et al.; Cell Death Differ. 9, 1115 (2002) Abstract
Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1: R. Schauvliege, et al.; J. Biol. Chem. 277, 41624 (2002) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-509 Revised 14-Aug-07
Monoclonal Antibody to Caspase-12 (mouse) (11F10)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-509-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 11F10
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N183KKFDYLFDRDNADTDILNMQEL205) of mouse caspase-12.
SPECIFICITY: Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION: ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
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Product Specific Literature References
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006) Abstract; Full Text
General Information
Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Monoclonal Antibodies
 
 
ALX-804-511 Revised 10-Mar-06
Monoclonal Antibody to Caspase-12 (mouse) (12G6)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-511-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 12G6
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N183KKFDYLFDRDNADTDILNMQEL205) of mouse caspase-12.
SPECIFICITY: Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION: ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Monoclonal Antibodies
 
 
ALX-804-228 Revised 19-Sep-05
Monoclonal Antibody to Caspase-14 (mouse) (70A1426)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-228-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 70A1426
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G affinity-purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 2-18 of mouse caspase-14.
SPECIFICITY: Recognizes mouse caspase-14. Detects a band of ~30kDa by Western blot.
APPLICATION: Western Blot (2-4µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
General Information
Caspase-14 (MICE for mini-ICE) is a recently member of the caspase family, related to human/mouse caspase-2 and human caspase-9. It possesses all the typical amino acid residues of the caspases involved in catalysis, including the QACRG box, and contains no or only a short prodomain. In contrast to the other short prodomain caspases (caspase-3, -6, -7), caspase-14 preferentially associates with large prodomain caspases, including caspase-1, -2, - 4, -8, and -10. Caspase-14 is not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapoptotic members of the bcl-2 family.
General Literature References
Caspase-14 is a novel developmentally regulated protease: S. Hu, et al.; J. Biol. Chem. 273, 29648 (1998) Abstract; Full Text
Identification of a new caspase homologue: caspase-14: M. Van de Craen, et al.; Cell Death Differ. 5, 838 (1998) Abstract
Identification and characterization of murine caspase-14, a new member of the caspase family: M. Ahmad, et al.; Cancer Res. 58, 5201 (1998) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-552 Revised 29-Jan-08
Monoclonal Antibody to CD14 (mouse) (biG 57)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY CD14 / Related Products
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ALX-804-552-C100   100 µg 400.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: biG 57
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Lyophilized. Contains no preservatives.
RECONSTITUTION: Reconstitute with 100µl distilled water.
IMMUNOGEN: Recombinant mouse CD14.
SPECIFICITY: Recognizes mouse CD14.
APPLICATION: ELISA
Flow Cytometry
Note: Does not inhibit binding of LPS to CD14.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
General Information
The CD14 glycoprotein, gp 55, is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in mouse serum, urine and other body fluids. The CD14 molecule has been reported to be a receptor for endotoxin.
BACKGROUND/TECHNICAL INFORMATION Binding titer at mouse CD14 transfected CHO-cells is more than 20’000.
Positive control: The antibody binds to mouse macrophage like cell line J774 (50%) and to native mouse CD14 in mouse EDTA-blood after 6 hours of stimulation with LPS (70%).
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-804-496 Revised 02-Jun-08
Monoclonal Antibody to CD14 (biG 10)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY CD14 / Related Products
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ALX-804-496-C100   100 µg 295.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Dog
Pig
Others
CLONE: biG 10
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Protein G affinity-purified.
FORMULATION: Lyophilized from PBS. Contains no preservatives.
RECONSTITUTION: Reconstitute with 100µl distilled water.
IMMUNOGEN: Monocytes and immunoaffinity purified soluble human CD14.
SPECIFICITY: Recognizes human (epitope aa 9-13 & aa 39-44), pig, dog, horse and bovine CD14.
APPLICATION: ELISA
Flow Cytometry
Western Blot
Functional Application (Inhibits binding of LPS to CD14; total inhibition at 100µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Mutation of amino acids 39-44 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli: F. Stelter, et al.; Eur J Biochem 243, 100 (1997) Abstract
General Information
The CD14 glycoprotein, gp 55, is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 molecule has been reported to be a receptor for endotoxin.
BACKGROUND/TECHNICAL INFORMATION Binding titer at human CD14 transfected CHO-cells is more than 10'000.
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-804-497 Revised 08-Feb-06
Monoclonal Antibody to CD14 (biG 14)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY CD14 / Related Products
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ALX-804-497-C100   100 µg 295.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Dog
Pig
Others
CLONE: biG 14
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Lyophilized from PBS. Contains no preservatives.
RECONSTITUTION: Reconstitute with 100µl distilled water.
IMMUNOGEN: Monocytes of different species and immunoaffinity purified soluble human CD14.
SPECIFICITY: Recognizes human (epitope aa 39-44), bovine, pig, dog, horse and guinea pig CD14.
APPLICATION: ELISA
Flow Cytometry
Western Blot
Functional Application (Inhibits binding of LPS to CD14; 1µg/ml MAb inhibits binding of 0.5µg/ml LPS to CD14).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Mutation of amino acids 39-44 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli: F. Stelter, et al.; Eur J Biochem 243, 100 (1997) Abstract
General Information
The CD14 glycoprotein, gp 55, is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 molecule has been reported to be a receptor for endotoxin.
BACKGROUND/TECHNICAL INFORMATION Binding titer at human CD14 transfected CHO-cells is more than 10'000.
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-804-498 Revised 18-Jul-07
Monoclonal Antibody to CD14 (human) (biG 2/RoMo-1)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY CD14 / Related Products
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ALX-804-498-C100   100 µg 295.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: biG 2/RoMo-1
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Lyophilized from PBS. Contains no preservatives.
RECONSTITUTION: Reconstitute with 100µl distilled water.
IMMUNOGEN: Human monocytes.
SPECIFICITY: Recognizes human (epitope aa 147-152) CD14.
APPLICATION: ELISA
Flow Cytometry
Immunoprecipitation
Note: Does not inhibit binding of LPS to CD14.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Mutation of amino acids 39-44 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli: F. Stelter, et al.; Eur J Biochem 243, 100 (1997) Abstract
General Information
The CD14 glycoprotein, gp 55, is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 molecule has been reported to be a receptor for endotoxin.
BACKGROUND/TECHNICAL INFORMATION Binding titer at human CD14 transfected CHO-cells (FACS) is 1:5000.
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-804-499 Revised 08-Apr-08
Monoclonal Antibody to CD14 (mouse) (biG 53)
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PRODUCT LINE Inflammation
PRODUCT CATEGORY CD14 / Related Products
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ALX-804-499-C100   100 µg 490.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: biG 53
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Lyophilized. Contains no preservatives.
RECONSTITUTION: Reconstitute with 100µl distilled water.
IMMUNOGEN: Recombinant mouse CD14.
SPECIFICITY: Recognizes mouse CD14. Binds to LPS-activated mouse monocytes.
APPLICATION: ELISA
Flow Cytometry
Functional Application (Inhibits binding of LPS to CD14; up to 1µg/ml CD14 inhibits binding of 0.5µg/ml FITC-LPS to 6x105 CD14+ CHO transfectants (FACS)).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
The CD14 glycoprotein, gp 55, is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in mouse serum, urine and other body fluids. The CD14 molecule has been reported to be a receptor for endotoxin.
BACKGROUND/TECHNICAL INFORMATION Binding titer at mouse CD14 transfected CHO-cells is more than 20'000.
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-803-302 Revised 06-Aug-07
Monoclonal Antibody to CHP1 (5E9G5)
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SYNONYMS anti-CHORD Containing Protein-1 MAb (5E9G5)
anti-CHORDC1 MAb (5E9G5)
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Cell Stress, Oxidative Stress & Redox Signalling Other Products
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ALX-803-302-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 5E9G5
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.2mg/ml
PURITY: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
PURITY DETAIL: Protein A-affinity purified.
IMMUNOGEN: Recombinant mouse CHP1 (CHORD containing protein-1).
SPECIFICITY: Recognizes human and mouse CHP1.
APPLICATION: ELISA
Immunocytochemistry (5µg/ml)
Immunohistochemistry (5µg/ml)
Immunoprecipitation (5µg per 5x106 cells)
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.