ALEXIS Biochemicals: Polyclonal Antibody to SOCS-1

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ALX-210-392

Revised 12-Jul-06

Polyclonal Antibody to SOCS-1
SYNONYMS	anti-Suppressor of Cytokine Signalling-1 PAb anti-JAB PAb anti-SSI-1 PAb anti-TIP-3 PAb
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	SOCS/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-392-R200		200 µl	267.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.1mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide containing aa residues of human SOCS-1 (suppressor of cytokine signalling-1).
SPECIFICITY:	Recognizes human and mouse SOCS-1.
APPLICATION:	Western Blot (1:500 - 1:1'000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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General Information

SOCS-1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signalling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin. SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signalling.

General Literature References

SOCS proteins: negative regulators of cytokine signaling: D.L. Krebs and D.J. Hilton; Stem Cells 19, 378 (2001) Abstract
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation: I. Kinjyo, et al.; Immunity 17, 583 (2002) Abstract
A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts: S. Ilangumaran, et al.; J. Immunol. 169, 5010 (2002) Abstract

Further Categories Containing This Product:

Toll-IL-1 Receptor Adapters & TLR Downstream Signalling Other Products • Polyclonal Antibodies

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