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Interleukin-1 [IL-1] Family & Receptors/Related Products
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ALX-350-371 Revised 10-Mar-08 New product
Harmine
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SYNONYMS Leucoharmine
Banisterine
Telepathine
Yageine
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation/Transcription
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ALX-350-371-M250   250 mg 22.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O
MW: 212.3
CAS NUMBER: 442-51-3
MERCK INDEX: 14: 4616
RTECS: UV0175000
SOURCE/HOST: Originally isolated from Peganum harmala.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Alkaloid of the β-carboline family. Regulates PPARγ expression. Inhibits the Wnt signalling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits monoamine oxidase inhibitor A (MAO-A), but has no effect on MAO-B.
Product Specific Literature References
The chemotherapy of derivatives of harmine and harmaline. I: C.E. Coulthard, et al.; Biochee. J. 27, 727 (1933) Abstract; Full Text
The chemotherapy of derivatives of harmine and harmaline. II: C.E. Coulthard; Biochem. J. 28, 264 (1934) Abstract; Full Text
Interrelationships between amphetamine and harmala alkaloids: H. Schmitt; Nature 203, 877 (1964) Abstract
Effect of moclobemide on rat brain monoamine oxidase A and B: comparison with harmaline and clorgyline: J. Gerardy; Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 793 (1994) Abstract
Hypothermic effect of harmala alkaloid in rats: involvement of serotonergic mechanism: A.F. Abdel-Fattah, et al.; Pharmacol. Biochem. Behav. 52, 421 (1995) Abstract
The mode of action of thiazolidinediones: H. Hauner; Diabet. Metab. Res. Rev. 18, S10 (2002) Abstract
Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis: Q. Chen, et al.; Int. J. Cancer 114, 675 (2005) Abstract
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression: H. Waki, et al.; Cell Metab. 5, 357 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Antidiabetic Agents/Related Products • Interleukin-1 [IL-1] & Receptors/Related Products • Wnt Signalling Pathway Other Products • TNF-alpha & TNF Receptors Other Products • NOS Regulation • Alkaloids
 
 
ALX-520-001 Revised 11-Apr-08
IL-1β (human) (recombinant) (cell culture grade)
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SYNONYMS Interleukin-1β (human) (recombinant) (cell culture grade)
IL-1F2 (human) (recombinant) (cell culture grade)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-520-001-C010   10 µg 297.00 USD Add To Cart
Product Specification
MW: ~17kDa.
CAS NUMBER: 97599-21-8
MERCK INDEX: 14: 4993
SOURCE/HOST: Produced in E. coli.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized. Salt-free.
ENDOTOXIN CONTENT: <1EU/µg protein.
RECONSTITUTION: Reconstitute with water, PBS or aqueous buffer to a concentration of 100µg/ml. For further dilution carrier protein (~1%) should be added to avoid loss of bioactivity.
BIOLOGICAL ACTIVITY: Exerts in vitro biological activity in the range of 0.1-10ng/ml.
SPECIFIC ACTIVITY: ≥1x107U/mg protein. Determined by proliferation assay using human TF-1 (T. Kitamura, et al.; Int. Immunol. 3, 571 (1991)). The ED50 for this effect is typically 0.2-2ng/ml. Results were compared with the international IL-1 reference standard preparation (WHO 86/680, NIBSC).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Potent immuno-modulator. Mediates a wide range of immune and inflammatory responses including the activation of B and T cells.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Interleukin-1 [IL-1] & Receptors/Related Products
 
 
ALX-522-056 Revised 18-Sep-07
IL-1β, Soluble (human) (recombinant)
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SYNONYMS Interleukin-1β, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-522-056-C010   10 µg 200.00 USD Add To Cart
ALX-522-056-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: Produced in E. coli. Human IL-1β (interleukin-1β) (aa 117-270) is fused to a linker peptide (10 aa) and an N-terminal FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
SPECIFICITY: Binds to human IL-1R (interleukin-1 receptor).
BIOLOGICAL ACTIVITY: Activates the NF-κB pathway.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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Product Specific Literature References
Insulin-secreting beta-cell dysfunction induced by human lipoproteins: M.E. Roehrich, et al.; J. Biol. Chem. 278, 18368 (2003) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P01584: Interleukin-1β (human) (precursor)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Human interleukin 1: I. Gery & J.A. Schmidt; Meth. Enzymol. 116, 456 (1985) Abstract
Interleukin 1: an immunological perspective: S.K. Durum, et al.; Annu. Rev. Immunol. 3, 263 (1985) Abstract
The in vivo effects of interleukin 1. I. Bone marrow cells are induced to cycle after administration of interleukin 1: R. Neta, et al.; J. Immunol. 139, 1861 (1987) Abstract
Interleukin 1 or tumor necrosis factor-alpha: which is the real target in rheumatoid arthritis?: J.M. Dayer; J. Rheumatol. Suppl. 65, 10 (2002) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Interleukin-1 [IL-1] & Receptors/Related Products
 
 
ALX-850-209 Revised 10-Apr-08
IL-1β (human) ELISA Kit
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SYNONYMS Interleukin-1β (human) ELISA Kit
IL-1F2 (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Kits & Sets
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ALX-850-209-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.32pg/ml (range 3.9 to 250pg/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human IL-1β in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store controls at -20°C. Store rest of the kit at +4°C.
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
Interleukin-1 [IL-1] & Receptors/Related Products • ELISA & EIA Kits
 
 
ALX-522-057 Revised 06-Jul-07
IL-1 Receptor Type I (human):Fc (human) (recombinant)
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SYNONYMS IL-1R I (human):Fc (human) (recombinant)
Interleukin-1 Receptor Type I (human):Fc (human) (recombinant)
CD121a (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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ALX-522-057-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~83kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water.
SPECIFICITY: Binds to human IL-1 (interleukin-1).
BIOLOGICAL ACTIVITY: Blocks IL-1 activity.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
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General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cytokine receptors and signal transduction: A. Miyajima, et al.; Annu. Rev. Immunol. 10, 295 (1992) Abstract
cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily: J.E. Sims, et al.; Science 241, 585 (1988) Abstract
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense: L.A. O'Neill; Sci. STKE 2000, RE1 (2000) Abstract
IL-1 and IL-18 receptors, and their extended family: J.E. Sims, et al.; Curr. Opin. Immunol. 14, 117 (2002) Abstract
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Further Categories Containing This Product:
CD Proteins • Recombinant Proteins/Fusion Proteins • Interleukin-1 [IL-1] & Receptors/Related Products
 
 
APO-54N-025 Revised 08-Apr-08
IL-33, Soluble (human) Detection Set [For ELISA Application]
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SYNONYMS Interleukin-33, Soluble (human) Detection Set [For ELISA Application]
NF-HEV, Soluble (human) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Kits & Sets
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APO-54N-025-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 5pg/ml (range 0 to 500pg/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of soluble human IL-33 from biological fluids (serum and cell culture supernatant). Does not cross-react with mouse IL-33.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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General Information
Interleukin-1 (IL-1) family members, such as IL-1α/β and IL-18 play important roles in host defense, immune regulation, neuronal injury and inflammation [1, 2]. Recently, a new member of this family, IL-33, also named Nuclear Factor from High Endothelial Venules (NF-HEV) [3], has been reported to be the specific ligand for ST2 [4], an orphan receptor of the IL-1 receptor family [5]. Structurally, IL-33 is closest to IL-18, rather than IL-1β. The human IL-33 is expressed with a prodomain (aa 1-111) that is cleaved by caspase-1 to produce a 18kDa mature protein (112-270) [6]. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK athways. IL-33 is synthesized in response to cytokines such as IL-1β (but also TNFα) and plays an important role in TH2-associated immunology, by triggering an increase secretion of IL-5 and IL-13 from polarized TH2 cells. Overexpression of IL-33 in mice leads to severe pathological changes in mucosal organs.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ5: Interleukin-33 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Differences in signaling pathways by IL-1beta and IL-18: J.K. Lee, et al. ; Proc. Natl. Acad. Sci. 101, 8815 (2004) Abstract
[2] Interleukin-1 and neuronal injury: S.M. Allan, et al.; Nat. Rev. Immunol. 5, 629 (2005) Abstract
[3] Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules: E.S. Baekkevold, et al. ; Am. J. Pathol. 163, 69 (2003) Abstract
[4] IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005) Abstract
[5] ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance: E.K. Brint, et al. ; Nat. Immunol. 5, 373 (2005) Abstract
[6] Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases: F. Martinon & J. Tschopp; Cell 117, 561 (2004) Abstract
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors/Related Products • ELISA Sets
 
 
ALX-201-363 Revised 18-Mar-08
IL-33 (human) (recombinant)
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SYNONYMS Interleukin-33 (human) (recombinant)
NF-HEV (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-201-363-C010   10 µg 295.00 USD Add To Cart
ALX-201-363-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Recombinant human IL-33 (aa 112-270) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SPECIFICITY: Binds to human ST2.
BIOLOGICAL ACTIVITY: Activates ST2-dependent NF-κB pathway.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ5: Interleukin-33 (human) (recombinant)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Interleukin-33 [IL-33] & Receptors/Related Products
 
 
ALX-522-098 Revised 27-Mar-08
IL-33 (human) (recombinant)
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SYNONYMS Interleukin-33 (human) (recombinant)
NF-HEV (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-522-098-C010   10 µg 190.00 USD Add To Cart
ALX-522-098-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~18kDa
SOURCE/HOST: Produced in E. coli. Untagged human IL-33 (aa 112-270).
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human ST2.
BIOLOGICAL ACTIVITY: Activates human ST2-dependent NF-κB pathway. Does not activate mouse ST2-dependent NF-κB.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo: V. Carriere et al.; PNAS 104, 282 (2007) Abstract
General Information
IL-33 is a new member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1 R4) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK pathways. The human IL-33 protein is expressed with a prodomain (aa 1-111) which is cleaved by caspase-1 to produce the 18kDa mature protein (112-270).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ5: Interleukin-33 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005) Abstract
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Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors/Related Products • Recombinant Proteins/Fusion Proteins
 
 
ALX-201-350 Revised 18-Mar-08
IL-33 (human) (recombinant) (His)
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SYNONYMS Interleukin-33 (human) (recombinant) (His)
NF-HEV (human) (recombinant) (His)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
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ALX-201-350-C010   10 µg 295.00 USD Add To Cart
ALX-201-350-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Recombinant human IL-33 (aa 112-270) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing
150mM sodium chloride.
ENDOTOXIN CONTENT: <1.0EU/µg protein (LAL-test).
SPECIFICITY: Binds to human ST2.
BIOLOGICAL ACTIVITY: Activates ST2-dependent NF-κB pathway.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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