Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
>
Inflammation
> Granzymes / Related Products
Granzymes
Granzyme Antibodies
Granzyme Inhibitors
Granzyme Substrates
Perforin / Related Products
Proteinase Inhibitor 9
Granzymes Other Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
1-20
of 30
Page 1
of 2
Select Page:
1
2
>>
ALX-260-043
Revised 13-Nov-06
Ac-IETD-CHO
SYNONYMS
Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-043-M001
1 mg
62.00 USD
ALX-260-043-M005
5 mg
243.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-CHO
FORMULA:
C
21
H
34
N
4
O
10
MW:
502.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Use always fresh solutions.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-10.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-056
Revised 11-Dec-07
Ac-ESMD-CHO
SYNONYMS
Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-056-M001
1 mg
83.00 USD
ALX-260-056-M005
5 mg
325.00 USD
Product Specification
SEQUENCE:
Ac-Glu-Ser-Met-Asp-CHO
FORMULA:
C
19
H
30
N
4
O
10
S
MW:
506.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥99% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in distilled water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Use always fresh solutions.
HANDLING:
Keep cool and dry. Keep under inert gas.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-6 and -10. The peptide sequence corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-073
Revised 20-Aug-07
Z-IE(OMe)TD(OMe)-FMK
SYNONYMS
Caspase-8 Inhibitor (Fluoromethylketone)
Granzyme B Inhibitor (Fluoromethylketone)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-073-M001
1 mg
220.00 USD
ALX-260-073-M005
5 mg
660.00 USD
Product Specification
SEQUENCE:
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone
FORMULA:
C
30
H
43
FN
4
O
11
MW:
654.7
PURITY:
≥90% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Store stock solutions in aliquots at -20°C.
HANDLING:
Packaged under inert gas.
Product Description
Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10.
Product Specific Literature References
Role of caspases in immunotoxin-induced apoptosis of cancer cells
:
A. Keppler-Hafkemeyer, et al.; Biochemistry
37
, 16934 (1998)
Abstract
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal:
D.A. Martin, et al.; J. Biol. Chem.
273
, 4345 (1998)
Abstract
;
Full Text
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide:
E.A. Sweeney, et al.; FEBS Lett.
425
, 61 (1998)
Abstract
Caspase-mediated proteolysis and activation of protein kinase Cδ plays a central role in neutrophil apoptosis
:
A. Khwaja & L. Tatton; Blood
94
, 291 (1999)
Abstract
;
Full Text
Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL
:
I.K. Kim, et al.; BBRC
277
, 311 (2000)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-144
Revised 01-Sep-05
Z-IETD-FMK (Ready-to-Use)
SYNONYMS
Caspase-8 Inhibitor (Fluoromethylketone) (Ready-to-Use)
Granzyme B Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-144-R100
2mM
100 µl
161.00 USD
ALX-260-144-R020
10mM
20 µl
161.00 USD
Product Specification
SEQUENCE:
Z-Ile-Glu-Thr-Asp-fluoromethylketone
MW:
654.0
PURITY:
≥99% (HPLC)
FORMULATION:
Liquid. In DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10.
General Information
BACKGROUND/TECHNICAL INFORMATION
We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-153
Revised 07-Nov-05
Z-AAD-CMK (Ready-to-Use)
SYNONYMS
Granzyme B Inhibitor (Ready-to-Use)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-153-R020
10mM
20 µl
175.00 USD
Product Specification
SEQUENCE:
Z-Ala-Ala-Asp-chloromethylketone
MW:
441.9
CONCENTRATION:
10mM
PURITY:
≥96% (HPLC)
FORMULATION:
Liquid. In DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Synthetic peptide that irreversibly inhibits granzyme B activity. The inhibitor is desigend as a methyl ester to facilitate cell permeability.
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-042
Revised 02-Oct-07
Ac-IETD-AMC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-042-M001
1 mg
42.00 USD
ALX-260-042-M005
5 mg
163.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
31
H
41
N
5
O
12
MW:
675.7
PEPTIDE CONTENT:
70-90%
PURITY:
≥98% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Fluorogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor
:
N.A. Maianski, et al.; J. Immunol.
172
, 7024 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-044
Revised 05-Apr-05
Z-IETD-pNA
SYNONYMS
Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-044-M001
1 mg
22.00 USD
ALX-260-044-M005
5 mg
83.00 USD
Product Specification
SEQUENCE:
Z-Ile-Glu-Thr-Asp-pNA (pNA = p-Nitroaniline)
FORMULA:
C
33
H
42
N
6
O
13
MW:
730.7
PEPTIDE CONTENT:
70-90%
PURITY:
≥99% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8 and granzyme B with increased cell permeability. Also substrate for caspase-10.
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-045
Revised 15-Dec-05
Ac-IETD-pNA
SYNONYMS
Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-045-M001
1 mg
22.00 USD
ALX-260-045-M005
5 mg
83.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-pNA (pNA=p-Nitroaniline)
FORMULA:
C
27
H
38
N
6
O
12
MW:
638.6
PEPTIDE CONTENT:
70-90%
PURITY:
98% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.0-7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Chromogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Apoptosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes:
C.A. Belmokhtar, et al.; J. Biol. Chem.
278
, 29571 (2003)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-050
Revised 18-Jan-05
BAADT
SYNONYMS
Granzyme B Substrate (Chromogenic)
Boc-AAD-SBzl
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-050-M001
1 mg
110.00 USD
ALX-260-050-M005
5 mg
410.00 USD
Product Specification
SEQUENCE:
Boc-Ala-Ala-Asp-SBzl
FORMULA:
C
22
H
31
N
3
O
7
S
MW:
481.6
PURITY:
≥96% (HPLC).
Single spot (TLC)
APPEARANCE:
White to off-white crystalline powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Very hygroscopic.
Product Description
Chromogenic substrate for granzyme B. λmax is at 405nm.
Product Specific Literature References
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins:
S. Odake, et al.; Biochemistry
30
, 2217 (1991)
Abstract
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-110
Revised 05-Apr-05
Ac-IETD-AFC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-110-M005
5 mg
157.00 USD
ALX-260-110-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
31
H
38
F
3
N
5
O
12
MW:
729.7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy:
D.J. Granville, et al.; FEBS Lett.
437
, 5 (1998)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-115
Revised 05-Apr-05
Ac-IEPD-AFC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-115-M005
5 mg
157.00 USD
ALX-260-115-M010
10 mg
295.00 USD
