• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Toll-IL-1 Receptor Adaptors & TLR Downstream Signalling
You are here: Product Lines > Inflammation > Toll-IL-1 Receptor Adaptors & TLR Downstream Signalling
 
Toolbar - View Selection
 
 Items 80-100 of 150 Page 5 of 8 Select Page: << 1 2 3 4 5 6 7 8  >>  
ALX-350-308 Revised 03-Apr-08
3-O-Acetyl-β-boswellic acid
Add to Clipboard
SYNONYMS AβBA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-308-M001   1 mg 45.00 USD Add To Cart
ALX-350-308-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C32H50O4
MW: 498.8
CAS NUMBER: 5968-70-7
SOURCE/HOST: Isolated from Boswellia sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone, dimethyl formamide, DMSO, dichloromethane, 100% ethanol or methanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, non-competitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-100 times more potent than natural boswellic acid.
Product Specific Literature References
Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers: V. Sterk, et al.; Planta Med. 70, 1155 (2004) Abstract
Effects of Boswellia serrata in mouse models of chemically induced colitis: P.R. Kiela, et al.; Am. J. Physiol. Gastrointest. Liver. Physiol. 288, G798 (2005) Abstract
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo: T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) Abstract; Full Text
Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid: D. Poeckel, et al.; Br. J. Pharmacol. 146, 514 (2005) Abstract
Boswellic acids: biological actions and molecular targets: D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006), Review Abstract
Further Categories Containing This Product:
Natural Products - NF-kB Pathway Inhibitors • Natural Products - Topoisomerase Inhibitors • Natural Products - Protein Kinase Inhibitors • NF-kB Pathway Inhibitors • Natural Products - Anti-inflammatory Agents • Antitumor Agents (Apoptosis Inducers) • Natural Products - Apoptosis Inducers & Inhibitors • Lipoxygenases / Related Products
 
 
ALX-550-398 Revised 10-Jul-08
N-Oleoyldopamine
Add to Clipboard
SYNONYMS OLDA
N-[2-(3,4-Dihydroxyphenyl)ethyl]-9Z-octadecenamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY TRPV1 Agonists and Antagonists / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-398-M005   5 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C26H43NO3
MW: 417.6
CAS NUMBER: 105955-11-1
CONCENTRATION: 50mg/ml 
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: 20mg/ml soluble in DMSO or dimethyl formamide; 0.5mg/ml soluble in a 1:1 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Protect from light.

Product Description
Endogenous TRPV1 agonist (Ki=36nM, EC50=36nM) with weak affinity for rat CB1 receptor (Ki=1.6µM). Potent inhibitor of 5-lipoxygenase (IC50=7.5nM) and of early and late events in TCR mediated T cell activation. Inhibits NF-κB dependent transcriptional activity without affecting either degradation of the cytoplasmic NF-κB inhibitory protein, IκBα, or DNA binding activity.
Product Specific Literature References
Inhibition of arachidonate 5-lipoxygenase by phenolic compounds: S. Iwakami, et al.; Chem. Pharm. Bull. 34, 3960 (1986) Abstract
Inhibition of in vitro prostaglandin and leukotriene biosyntheses by cinnamoyl-beta-phenethylamine and N-acyldopamine derivatives: C.F. Tseng, et al.; Chem. Pharm. Bull. 40, 396 (1992) Abstract
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia: C.J. Chu, et al.; J. Biol. Chem. 278, 13633 (2003) Abstract
Direct evidence for activation and desensitization of the capsaicin receptor by N-oleoyldopamine on TRPV1-transfected cell, line in gene deleted mice and in the rat: J. Szolcsanyi, et al.; Neurosci. Lett. 361, 155 (2004) Abstract
Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways: R. Sancho, et al.; J. Immunol. 172, 2341 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Endovanilloids • NF-kB Pathway Inhibitors • Lipoxygenases / Related Products
 
 
ALX-350-301 Revised 14-May-07
Oxaspirodion
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-301-MC05   0.5 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C13H14O5
MW: 250.3
SOURCE/HOST: Isolated from Chaetomium subspirale.
APPEARANCE: Orange to brown oil.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Mixture of 4 non-separable isomers. Inhibits TNF-α expression (IC50=2.5µg/ml). Exhibits no antibacterial and antifungal activities up to 100µg/disk in the standard disk assay. Weak cytotoxic properties against tumor cells. Inhibition of the TNF-α promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibits the activation of the transcription factor NF-κB, which is involved in the inducible expression of many proinflammatory genes.
Product Specific Literature References
Oxaspirodion, a new inhibitor of inducible TNF-alpha expression from the Ascomycete chaetomium subspirale. Production, isolation and structure elucidation: J. Rether, et al.; J. Antibiot. 57, 493 (2004) Abstract
Inhibition of inducible TNF-alpha expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale: J. Rether, et al.; Biol. Chem. 385, 829 (2004) Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • TNF-alpha & TNF Receptors Other Products
 
 
ALX-350-109 Revised 29-Nov-07
Panepoxydone
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-109-MC05   0.5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C11H14O4
MW: 210.2
SOURCE/HOST: Isolated from Lentinus crinitus.
PURITY: >95% (HPLC)
FORMULATION: Yellow oil
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light. Keep cool and dry.
HAZARD: TOXIC.

Product Description
Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.
Product Specific Literature References
Inhibition of NF-kappa B activation by panepoxydone: G. Erkel, et al.; BBRC 226, 214 (1996) Abstract
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways: H. Kleinert, et al.; Br. J. Pharmacol. 125, 193 (1998) Abstract
Naturally occurring and synthetic inhibitors of NF-kappaB functions: K. Umezawa, et al.; Anticancer Drug Des. 15, 239 (2000) Abstract
Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent: J.B. Shotwell, et al.; Bioorg. Med. Chem. Lett. 12, 3463 (2002) Abstract
Molecular design and biological activities of NF-kappaB inhibitors: K. Umezawa & C. Chaicharoenpong; Mol. Cells 14, 163 (2002) Abstract
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells: G. Erkel, et al.; Int. Immunopharmacol. 7, 612 (2007) Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products with Antibiotic Activity
 
 
ALX-350-258 Revised 08-Apr-08
Parthenolide
Add to Clipboard
SYNONYMS (1aR-[1aR*,4E,7aS*,-10aS*,-10bR*])-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclo deca[1,2-b]furan-9(1aH)-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-258-M005   5 mg 15.00 USD Add To Cart
ALX-350-258-M025   25 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C15H20O3
MW: 248.3
CAS NUMBER: 20554-84-1
MERCK INDEX: 14: 7048
RTECS: LY4220000
SOURCE/HOST: Isolated from feverfew leaves.
PURITY: ≥99% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (100mg/ml), dichloromethane (50mg/ml) or 100% ethanol (20mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Sesquiterpene lactone. Anti-inflammatory compound. Specifically inhibits activation of NF-κB by preventing the degradation of IκBα and IκBβ. Inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B4 and thromboxane B2. Potent anticancer agent. Induces apoptosis in various cancer cell lines. Specifically inhibits histone deacetylase 1 (HDAC1) without affecting other class I/II HDACs. Inhibits tubulin carboxypeptidase (TCP) activity.
Product Specific Literature References
A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro: W.A. Groenewegen & S. Heptinstall; J. Pharm. Pharmacol. 42, 553 (1990) Abstract
Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta: R.W. Barsby, et al.; J. Pharm. Pharmacol. 44, 737 (1992) Abstract
Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components: H. Sumner, et al.; Biochem. Pharmacol. 43, 2313 (1992) Abstract
Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases: D. Hwang, et al.; BBRC 226, 810 (1996) Abstract
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta: S.P. Hehner, et al.; J. Biol. Chem. 273, 1288 (1998) Abstract
Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells: H.R. Wong & I.Y. Menendez; BBRC 262, 375 (1999) Abstract
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF- kappa B by targeting the I kappa B kinase complex: S.P. Hehner, et al.; J. Immunol. 163, 5617 (1999) Abstract
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide: N.M. Patel, et al.; Oncogene 19, 4159 (2000) Abstract
Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase: H. Nakshatri, et al.; Oncogene 23, 7330 (2004) Abstract
Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis: S. Zhang, et al.; Cancer Lett. 211, 175 (2004) Abstract
Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity: W. Wang, et al.; Apoptosis 11, 2225 (2006) Abstract
Parthenolide inhibits tubulin carboxypeptidase activity: X. Fonrose, et al.; Cancer Res. 67, 3371 (2007) Abstract
Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated: Y.N. Gopal, et al.; Chem. Biol. 14, 813 (2007) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors • COX Inhibitors • Natural Products - NF-kB Pathway Inhibitors • NF-kB Pathway Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Other Natural Products for Inflammation Research
 
 
ALX-850-286 Revised 28-Sep-06
Phospho-IκBα ActivELISA™ Assay Kit
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inhibitors of kappa B [IkB] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-286-KI01   1 Kit 559.00 USD Add To Cart
Product Specification
QUANTITY: 2x96 wells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Description
ELISA based assay for the detection and analysis of IκBα-phosphorylation. Phosphorylation of IκBα is correlated with the activity of the IKK complex as well as the nuclear localization and activation of NF-κB.
General Information
MANUFACTURER Manufactured by Imgenex.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-210-370 Revised 07-Aug-06
Polyclonal Antibody to ABIN-2
Add to Clipboard
SYNONYMS anti-A20-Binding Inhibitor of NF-κB 2 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-370-C100   100 µg 267.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptides corresponding to human ABIN-2 (A20-binding inhibitor of NF-κB 2).
SPECIFICITY: Recognizes human and mouse ABIN-2. Detects a band of ~66kDa by Western blot.
APPLICATION: Western Blot (0.5-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
TLRs Other Products • Polyclonal Antibodies
 
 
ALX-210-905 Revised 23-May-08
Polyclonal Antibody to Asc (AL177)
Add to Clipboard
SYNONYMS anti-Pycard PAb (AL177)
anti-Apoptosis-associated Speck-like Protein Containing CARD PAb (AL177)
anti-TMS1 PAb (AL177)
anti-Target of Methylation-induced Silencing 1 PAb (AL177)
anti-CARD5 PAb (AL177)
anti-Caspase Recruitment Domain-containing Protein 5 PAb (AL177)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-905-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 2-27 (G2RARDAILDALENLTAEELKKFKLKL27) of N-terminal human Asc (apoptosis-associated speck-like protein containing CARD; Pycard).
SPECIFICITY: Recognizes human and mouse Asc.
APPLICATION: Immunocytochemistry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: For Positive Control (Western blot) see Prod. No. ALX-840-602.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon, et al.; Mol. Cell. 10, 417 (2002) Abstract
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini, et al.; Immunity 20, 319 (2004) Abstract
P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1{beta} in Mouse Macrophage: P. Pelegrin, et al.; J. Immunol. 180, 7147 (2008) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Signalling: Initiation of pro-IL-1beta processing: E. Bell; Nat. Rev. Immunol. 2, 719 (2002) Abstract
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1: S.M. Srinivasula, et al.; J. Biol. Chem. 277, 21119 (2002) Abstract
NALPS: a novel protein family involved in inflammation: J. Tschopp, et al.; Nat. Rev. Mol. Cell Biol. 4, 95 (2003), (Review) Abstract; Full Text
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products • Polyclonal Antibodies
 
 
ALX-210-929 Revised 16-Apr-08
Polyclonal Antibody to Cardif (human) (AT107)
Add to Clipboard
SYNONYMS anti-CARD Adapter Inducing Interferon-β (human) PAb (AT107)
anti-IPS-1 (human) PAb (AT107)
anti-Interferon-β Promoter Stimulator Protein 1 (human) PAb (AT107)
anti-MAVS (human) PAb (AT107)
anti-Mitochondrial Antiviral Signalling Protein (human) PAb (AT107)
anti-VISA (human) PAb (AT107)
anti-Virus-induced Signalling Adapter (human) PAb (AT107)
PRODUCT LINE Immunology
PRODUCT CATEGORY Antiviral Signalling / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-929-C100   100 µg 370.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human Cardif (CARD adapter inducing interferon-β) (aa 160-450).
SPECIFICITY: Recognizes human cardif.
APPLICATION: Immunocytochemistry (1:500)
Immunoprecipitation (1:100)
Western Blot (1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif : S. K. Saha; EMBO J. 25, 3257 (2006) Abstract
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity: Y.M. Loo, et al.; J. Virol. 82, 335 (2008) Abstract
General Information
RIG-I (retinoic acid-inducible gene I; Ddx58) and Mda5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-κB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons.
Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and Mda5, leading to the activation of NF-κB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-β production.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus: E. Meylan, et al.; Nature 437, 1167 (2005) Abstract
VISA is an adapter protein required for virus-triggered IFN-beta signaling: L.G. Xu, et al.; Mol. Cell 19, 727 (2005) Abstract
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction: T. Kawai, et al.; Nat. Immunol. 6, 981 (2005) Abstract
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3: R.B. Seth, et al.; Cell 122, 669 (2005) Abstract
CARD games between virus and host get a new player: C.L. Johnson and M. Gale, Jr.;