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Caspases / Related Products
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ALX-260-074 Revised 04-Nov-05
Z-YVAD(OMe)-FMK
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SYNONYMS Caspase-1 Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-074-M001   1 mg 331.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone
FORMULA: C31H39FN4O9
MW: 630.7
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING: Packaged under inert gas.
Product Description
Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.
Product Specific Literature References
The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells: B.A. Eldadah, et al.; J. Neurosci. 17, 6105 (1997) Abstract; Full Text
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells: X.M. Zhang, et al.; Biochem. J. 340, 127 (1999) Abstract; Full Text
Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo: C. Wiessner, et al.; Cell Mol. Biol. (Noisy-Le-Grand) 46, 53 (2000) Abstract
 
 
ALX-260-049 Revised 10-Feb-05
Z-YVAD-pNA
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SYNONYMS Caspase-1 Substrate (Chromogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-049-M001   1 mg 27.00 USD Add To Cart
ALX-260-049-M005   5 mg 98.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Tyr-Val-Ala-Asp-pNA (pNA = p-Nitroaniline)
FORMULA: C35H40N6O11
MW: 720.7
PEPTIDE CONTENT: 70-90%
PURITY: ≥99% (HPLC)
APPEARANCE: White powder.
FORMULATION: Lyophilized. TFA salt.
SOLUBILITY: Soluble in DMSO. Can be diluted with basic buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Chromogenic substrate for caspase-1 with increased cell permeability. λmax of pNA is 400nm.
 
 
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