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Toll-like Receptors [TLRs] / Related Products
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ALX-270-066 Revised 07-Apr-08
Lavendustin C
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SYNONYMS Compound 5
5-(N-2,5-Dihydroxybenzyl)aminosalicylic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-270-066-M001   1 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C14H13NO5
MW: 275.3
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Potent inhibitor of protein tyrosine kinases and Ca2+/calmodulin-dependent kinase II. Acts also as an inhibitor of EGFR tyrosine kinase and pp60c-src kinase.
Product Specific Literature References
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus: T. Onoda, et al.; J. Nat. Prod. 52, 1252 (1989) Abstract
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors: T.J. O'Dell, et al.; Nature 353, 558 (1991) Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989) Abstract
Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor: H.M. Burt, et al.; J. Leukoc. Biol. 55, 112 (1994) Abstract
Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway: D. Lidington, et al.; J. Cell Physiol. 185, 117 (2000) Abstract
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Further Categories Containing This Product:
CAM Kinase Inhibitors • Tyrosine Kinase Inhibitors • EGFR Kinase Inhibitors • Lipopolysaccharides [LPS] / Related Products
 
 
ALX-350-227 Revised 28-Apr-08
Myristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-227-M100   100 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C11H12O3
MW: 192.2
CAS NUMBER: 607-91-0
MERCK INDEX: 14: 6334
SOURCE/HOST: Isolated from Petroselinium hortense Hoffmann.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless to slightly yellow liquid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Natural product isolated from parsley oil. Inducer of glutathione S-transferases. Also inhibits chemical carcinogenesis. Induces rat and human cytochrome P450 enzymes. Has very potent hepatoprotective activity. Induces apoptosis.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.-Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Induction of rat hepatic cytochrome P450 enzymes by myristicin: H.G. Jeong & C.H. Yun; BBRC 217, 966 (1995) Abstract
Toxicological evaluation of myristicin: H. Hallstrom & A. Thuvander; Nat. Toxins 5, 186 (1997), Review Abstract
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin: C.H. Yun, et al.; Toxicol. Lett. 137, 143 (2003) Abstract
Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/ d-galactosamine-induced liver injury: T. Morita, et al.; J. Agric. Food Chem. 51, 1560 (2003) Abstract
Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells: B.K. Lee, et al.; Toxicol. Lett. 157, 49 (2005) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Cytochrome P450 [CYP450] / Related Products • Glutathione S-Transferase • Active Substances from Fruit and Vegetables • Natural Products - Apoptosis Inducers & Inhibitors • Lipopolysaccharides [LPS] / Related Products
 
 
ALX-581-001 Revised 03-Apr-07
LPS from E. coli, Serotype O55:B5 - Replaced by Prod. No. ALX-581-013
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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not sold in USA
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ALX-581-002 Revised 14-Feb-07
LPS from E. coli, Serotype O111:B4 - Replaced by Prod. No. ALX-581-012
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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not sold in USA
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ALX-581-004 Revised 14-Feb-07
LPS from Salmonella typhimurium - Replaced by Prod. No. ALX-581-011
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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not sold in USA
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ALX-581-007 Revised 16-Sep-08
LPS from E. coli, Serotype R515 (Re) (TLRgrade™) (Ready-to-Use)
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SYNONYMS Lipopolysaccharide from E. coli, Serotype R515 (Re) (TLRgrade™) (Ready-to-Use)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-007-L002   2 ml 155.00 USD Add To Cart
Product Specification
SOURCE/HOST: Rough (R)-form LPS isolated and purified from E. coli R515 (Re mutant) by a modification of the PCP extraction method [1,2], converted to the uniform sodium salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Strong activator of Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Use must be restricted to qualified personnel. Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream. Keep sterile.
HAZARD: HIGHLY PYROGENIC. HARMFUL.
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Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Meth. Carbohydrate. Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells: M. Huber, et al.; Eur. J. Immunol. 36, 701 (2006) Abstract
[5] The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies: N. Satta, et al.; Blood 109, 1507 (2007) Abstract
 
 
ALX-581-008 Revised 10-Sep-08
LPS from Salmonella minnesota R595 (Re) (TLRgrade™) (Ready-to-Use)
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SYNONYMS Lipopolysaccharide from Salmonella minnesota R595 (Re) (TLRgrade™) (Ready-to-Use)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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ALX-581-008-L002   2 ml 155.00 USD Add To Cart
Product Specification
RTECS: UX2990000
SOURCE/HOST: Rough (R)-form LPS, isolated and purified from Salmonella minnesota R595 (Re mutant) by a modification of the PCP extraction method [1,2], converted to the uniform sodium salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Strong activator of Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream. Keep sterile. Use must be restricted to qualified personnel.
HAZARD: HARMFUL. HIGHLY PYROGENIC.
Product Images
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Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Methods in Carbohydrate Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4: C. Termeer, et al.; J. Exp. Med. 195, 99 (2002) Abstract; Full Text
[5] CD36 is a sensor of diacylglycerides: K. Hoebe, et al.; Nature 433, 523 (2005) Abstract
[6] CD14 is required for MyD88-independent LPS signaling: Z. Jiang, et al.; Nat. Immunol. 6, 565 (2005 6, 565 (2005) Abstract
[7] Toll-like receptor 9-induced type I IFN protects mice from experimental colitis: K. Katakura, et al.; J. Clin. Invest. 115, 695 (2005) Abstract; Full Text
[8] R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells: M. Huber, et al.; Eur. J. Immunol. 36, 701 (2006) Abstract
 
 
ALX-581-009 Revised 16-Sep-08
LPS from Salmonella abortus equi S-form (TLRgrade™) (Ready-to-Use)
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SYNONYMS Lipopolysaccharide from Salmonella abortus equi S-form (TLRgrade™) (Ready-to-Use)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-009-L002   2 ml 155.00 USD Add To Cart
Product Specification
SOURCE/HOST: Smooth (S)-form LPS, isolated and purified from Salmonella abortus equi by modification of the phenol water extraction and PCP method [1,2], converted to the uniform salt form [3] and dissolved in pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Strong activator of Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Keep sterile. Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream. Use must be restricted to qualified personnel.
HAZARD: HIGHLY PYROGENIC. HARMFUL.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Methods in Carbohydrate Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] Preparation and properties of a standardized lipopolysaccharide from salmonella abortus equi (Novo-Pyrexal)  : C. Galanos et al.; Zentralbl. Bakteriol. [Orig. A] 243, 226 (1979) Abstract
[5] Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4: C. Termeer, et al.; J. Exp. Med. 195, 99 (2002) Abstract; Full Text
[6] Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice: C. Kalis, et al.; Eur. J. Immunol. 33, 798 (2003) Abstract
[7] A striking correlation between lethal activity and apoptotic DNA fragmentation of liver in response of D-galactosamine-sensitized mice to a non-lethal amount of lipopolysaccharide: B.R. Zhou, et al.; Acta Pharmacol. Sin. 24, 193 (2003) Abstract; Full Text
[8] CD14 is required for MyD88-independent LPS signaling: Z. Jiang, et al.; Nat. Immunol. 6, 565 (2005) Abstract
[9] IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella Enteritidis and the impact of IL-10 in bone marrow-derived macrophages: N. Schuetze, et al.; Int. Immunol. 17, 649 (2005) Abstract
[10] R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells: M. Huber, et al.; Eur. J. Immunol. 36, 701 (2006) Abstract
[11] Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis: S. Siegemund, et al.; Immunobiology 212, 739 (2008) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Related Product:

- For the biotinylated LPS, please see LPS from Salmonella abortus equi S-form (TLRgrade™) (Ready-to-Use) (Biotin) (Prod. No. ALX-581-150).
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ALX-581-010 Revised 10-Sep-08
LPS from E. coli, Serotype EH100 (Ra) (TLRgrade™) (Ready-to-Use)
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SYNONYMS Lipopolysaccharide from E. coli, Serotype EH100(Ra) (TLRgrade™) (Ready-to-Use)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-010-L002   2 ml 155.00 USD Add To Cart
Product Specification
SOURCE/HOST: Rough (R)-form LPS isolated and purified from E. coli EH100 (Ra-mutant) by a modification of the PCP extraction method [1,2], converted to the uniform sodium salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in double distilled, pyrogen-free water.
ACTIVITY: Strong activator of Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream. Keep sterile. Use must be restricted to qualified personnel.
HAZARD: HIGHLY PYROGENIC. HARMFUL.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Meth. Carbohydrate. Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells: M. Huber, et al.; Eur. J. Immunol. 36, 701 (2006) Abstract
 
 
ALX-581-011 Revised 10-Sep-08
LPS from Salmonella typhimurium S-form (TLRgrade™) (Ready-to-Use)
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SYNONYMS Lipopolysaccharide from Salmonella typhimurium S-form (TLRgrade™) (Ready-to-Use)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-011-L002   2 ml 155.00 USD Add To Cart
Product Specification
RTECS: OJ0895637
SOURCE/HOST: Smooth (S)-form LPS, isolated and purified from Salmonella typhimurium by modification of the phenol water extraction and PCP method [1,2], converted to the uniform salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Specific activator of Toll-like receptor (TLR) 4 [4]. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream. Keep sterile. Use must be restricted to qualified personnel.
HAZARD: HARMFUL. HIGHLY PYROGENIC.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C Galanos & O. Luderitz; Meth. Carbohydrate Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] CD14 is required for MyD88-independent LPS signaling: Z. Jiang, et al.; Nat. Immunol. 6, 565 (2005) Abstract
[5] R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells: M. Huber, et al.; Eur. J. Immunol. 36, 701 (2006) Abstract
 
 
ALX-581-012 Revised 12-Sep-08
LPS from E. coli, Serotype O111:B4 (TLRgrade™) (Ready-to-Use)
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SYNONYMS Lipopolysaccharide from E. coli, Serotype O111:B4 S-form (TLRgrade™) (Ready-to-Use)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-012-L002   2 ml 155.00 USD Add To Cart
Product Specification
RTECS: OJ0895400
SOURCE/HOST: Smooth (S)-form LPS isolated and purified from E. coli O111:B4 by a modification of the phenol water extraction and PCP extraction method [1,2], converted to the uniform sodium salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: Absence of detectable protein or DNA contaminants with agonistic TLR activity.
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Specific activator of Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice.
Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at +4°C.
HANDLING: Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Avoid inhalation of LPS and prevent these compounds from entering the bloodstream. Keep sterile. Use must be restricted to qualified personnel.
HAZARD: