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Inflammation
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ALX-210-905 Revised 23-May-08
Polyclonal Antibody to Asc (AL177)
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SYNONYMS anti-Pycard PAb (AL177)
anti-Apoptosis-associated Speck-like Protein Containing CARD PAb (AL177)
anti-TMS1 PAb (AL177)
anti-Target of Methylation-induced Silencing 1 PAb (AL177)
anti-CARD5 PAb (AL177)
anti-Caspase Recruitment Domain-containing Protein 5 PAb (AL177)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-905-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 2-27 (G2RARDAILDALENLTAEELKKFKLKL27) of N-terminal human Asc (apoptosis-associated speck-like protein containing CARD; Pycard).
SPECIFICITY: Recognizes human and mouse Asc.
APPLICATION: Immunocytochemistry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
POSITIVE CONTROL: For Positive Control (Western blot) see Prod. No. ALX-840-602.
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Product Specific Literature References
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon, et al.; Mol. Cell. 10, 417 (2002) Abstract
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini, et al.; Immunity 20, 319 (2004) Abstract
P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1{beta} in Mouse Macrophage: P. Pelegrin, et al.; J. Immunol. 180, 7147 (2008) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Signalling: Initiation of pro-IL-1beta processing: E. Bell; Nat. Rev. Immunol. 2, 719 (2002) Abstract
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1: S.M. Srinivasula, et al.; J. Biol. Chem. 277, 21119 (2002) Abstract
NALPS: a novel protein family involved in inflammation: J. Tschopp, et al.; Nat. Rev. Mol. Cell Biol. 4, 95 (2003), (Review) Abstract; Full Text
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins/Related Products • Polyclonal Antibodies
 
 
ALX-210-908 Revised 14-Jan-08
Polyclonal Antibody to TRIF (human) (AL227)
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SYNONYMS anti-TICAM-1 (human) PAb (AL227)
anti-TIR-containing Adaptor Molecule-1 (human) PAb (AL227)
anti-Toll-interleukin-1 Receptor [TIR] Domain-containing Adaptor Inducing Interferon-β [IFN-β] (human) PAb (AL227)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Toll-IL-1 Receptor Adaptors/Related Products
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ALX-210-908-C050   50 µg 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 4-31 (T4GPSLPSAFDIL
GAAGQDKLLYLKHKLK31) of N-terminal human TRIF [TICAM-1].
SPECIFICITY: Recognizes human TRIF.
APPLICATION: Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling: M. Carty, et al.; Nat. Immunol. 7, 1074 (2006) Abstract
Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells: E. Aksoy, et al.; Blood 109, 2887 (2007) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Antiviral Signalling/Related Products • Polyclonal Antibodies
 
 
ALX-210-910 Revised 29-Feb-08
Polyclonal Antibody to CYLD (human) (AF888)
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SYNONYMS anti-Cylindromatosis Tumor Suppressor Protein (human) PAb (AF888)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Other Products
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ALX-210-910-C050   50 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.45mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 1% BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 56-70 (G56HSRIPSAKGKKNQI70) of human CYLD (cylindromatosis tumor suppressor protein).
SPECIFICITY: Recognizes human CYLD. Detects a band of ~120kDa by Western blot.
APPLICATION: Immunocytochemistry (on transfected cells; 1:200)
Western Blot (on transfected cells; 1:3'000).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
The tumor suppressor CYLD Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7: H. Yoshida, et al.; J. Biol. Chem. 280, 41111 (2005) Abstract; Full Text
General Information
Cylindromas are benign adnexal skin tumors caused by germ line mutations in the CYLD gene. In most cases the second wild type allele is lost in tumor tissue suggesting that CYLD functions as tumor-suppressor. CYLD is a protein of 956 amino acids harboring a functional deubiquitinating domain at the C-terminal end. CYLD was shown to interact with TRAF2, NEMO and TRIP (Trompouki et al.; Brummelkamp et al.; Kovalenko et al.; Regamey et al.). Furthermore, CYLD is a negative regulator of NF-κB activation mediated by TNF family members and IL-1β. Downregulation of NF-κB activity depends on the deubiquitinating activity of CYLD which removes lysine-63 linked ubiquitin chains from target proteins. These findings indicate that cylindromas arise through constitutive NF-κB activation leading to hyperproliferation and tumor growth.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members: E. Trompouki, et al.; Nature 424, 793 (2003) Abstract
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB: T.R. Brummelkamp, et al.; Nature 424, 797 (2003) Abstract
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination: A. Kovalenko, et al.; Nature 424, 801 (2003) Abstract
The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor: A. Regamey, et al.; J. Exp. Med. 198, 1959 (2003) Abstract
Further Categories Containing This Product:
Deubiquitination Other Products • Polyclonal Antibodies • Tumor Suppressors/Related Products
 
 
ALX-210-914 Revised 25-Jan-08
Polyclonal Antibody to TRAM (human) (AL239)
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SYNONYMS anti-TRIF-related Adaptor Molecule (human) PAb (AL239)
anti-TIRP (human) PAb (AL239)
anti-Toll-Interleukin 1 Receptor [TIR] Domain-containing Protein (human) PAb (AL239)
anti-TICAM-2 (human) PAb (AL239)
anti-TIR-containing Adaptor Molecule-2 (human) PAb (AL239)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Toll-IL-1 Receptor Adaptors/Related Products
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ALX-210-914-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Synthetic peptide corresponding to aa 2-29 (G2IGKSKINSC
PLSLSWGKRHSVDTSPGY29) of human TRAM (TRIF-related adaptor molecule).
SPECIFICITY: Recognizes human TRAM.
APPLICATION: Western Blot (1:1’000).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells: E. Aksoy, et al.; Blood 109, 2887 (2007) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling: L.H. Bin, et al.; J. Biol. Chem. 278, 24526 (2003) Abstract; Full Text
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway: M. Yamamoto, et al.; Nat. Immunol. 4, 1144 (2003) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-917 Revised 02-Nov-06
Polyclonal Antibody to SET (human)
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SYNONYMS anti-PHAPII (human) PAb
anti-I2αPP2A (human) PAb
anti-Phosphatase 2A Inhibitor Protein 2α (human) PAb
anti-HLA-DR-associated Protein 2 (human) PAb
anti-IGAAD (human) PAb
anti-Inhibitor of Granzyme-activated DNase (human) PAb
anti-TAF-Iβ (human) PAb
anti-Template-activating Factor Iβ (human) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2A/Related Products
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ALX-210-917-C050   50 µg 194.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A affinity-purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 3-16 (A3PAAKVSKKELNSN16) of human SETβ.
SPECIFICITY: Recognizes human SETβ. Detects endogenous protein by IP and WB.
APPLICATION: Flow cytometry (1:100-1:200);
Immunocytochemistry;
Immunoprecipitation;
Western blot (1:1'000).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt if stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks: P.J. Beresford, et al.; J. Biol. Chem. 276, 43285 (2001) Abstract; Full Text
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A: Z. Fan, et al.; Mol. Cell. Biol. 22, 2810 (2002) Abstract; Full Text
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A: Z. Fan, et al.; Nat. Immunol. 4, 145 (2003) Abstract
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor: Z. Fan, et al.; Cell 112, 659 (2003) Abstract
Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis: D. Martinvalet, et al.; Immunity 22, 355 (2005) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Granzymes Other Products • Polyclonal Antibodies
 
 
ALX-210-918 Revised 25-Jan-08
Polyclonal Antibody to Nod1 (human) (AL184)
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SYNONYMS anti-CARD4 (human) PAb (AL184)
anti-Caspase Recruitment Domain-containing Protein 4 (human) PAb (AL184)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Nod-complex/Related Products
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ALX-210-918-C050   50 µg 194.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Affinity-purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 2-31 (E2EQGHSEMEIIP
SESHPHIQLLKSNRELLV31) of human Nod1 [CARD4].
SPECIFICITY: Recognizes human Nod1.
APPLICATION: Western blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition: T. Tanabe, et al.; EMBO J. 23, 1587 (2004) Abstract
Further Categories Containing This Product:
Adaptor Proteins for Death Receptors Other Products • Polyclonal Antibodies
 
 
ALX-210-928 Revised 08-Nov-07
Polyclonal Antibody to LRRK2 (human) (AT106)
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SYNONYMS anti-Leucine-rich Repeat Kinase 2 (human) PAb (AT106)
anti-RIP7 (human) PAb (AT106)
anti-PARK8 (human) PAb (AT106)
anti-Dardarin (human) PAb (AT106)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY RIP Kinases
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ALX-210-928-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human LRRK2 (leucine-rich repeat kinase 2) (aa 1838-2133).
SPECIFICITY: Recognizes human LRRK2. The strongest recognized epitope is PDQPRLTIPISQ (aa 1843-1854) as defined by epitope mapping.
APPLICATION: Immunohistochemistry (paraffin sections (1:500))
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
LRRK2 in Parkinson’s disease and dementia with Lewy bodies: X. Zhu, et al.; Mol. Neurodegener. 1, 17 (2006) Abstract; Full Text
General Information
LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease: C. Paisan-Ruiz, et al.; Neuron 44, 595 (2004) Abstract
From The Cover: Parkinson’s disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity: A.B. West, et al.; PNAS 102, 16842 (2005) Abstract
The RIP kinases: crucial integrators of cellular stress: E. Meylan and J. Tschopp; TIBS 30, 151 (2005) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • Parkinson's Disease Other Products
 
 
ALX-210-929 Revised 16-Apr-08
Polyclonal Antibody to Cardif (human) (AT107)
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SYNONYMS anti-CARD Adapter Inducing Interferon-β (human) PAb (AT107)
anti-IPS-1 (human) PAb (AT107)
anti-Interferon-β Promoter Stimulator Protein 1 (human) PAb (AT107)
anti-MAVS (human) PAb (AT107)
anti-Mitochondrial Antiviral Signalling Protein (human) PAb (AT107)
anti-VISA (human) PAb (AT107)
anti-Virus-induced Signalling Adapter (human) PAb (AT107)
PRODUCT LINE Immunology
PRODUCT CATEGORY Antiviral Signalling/Related Products
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ALX-210-929-C100   100 µg 370.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human Cardif (CARD adapter inducing interferon-β) (aa 160-450).
SPECIFICITY: Recognizes human cardif.
APPLICATION: Immunocytochemistry (1:500)
Immunoprecipitation (1:100)
Western Blot (1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif : S. K. Saha; EMBO J. 25, 3257 (2006) Abstract
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity: Y.M. Loo, et al.; J. Virol. 82, 335 (2008) Abstract
General Information
RIG-I (retinoic acid-inducible gene I; Ddx58) and Mda5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-κB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons.
Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and Mda5, leading to the activation of NF-κB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-β production.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus: E. Meylan, et al.; Nature 437, 1167 (2005) Abstract
VISA is an adapter protein required for virus-triggered IFN-beta signaling: L.G. Xu, et al.; Mol. Cell 19, 727 (2005) Abstract
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction: T. Kawai, et al.; Nat. Immunol. 6, 981 (2005) Abstract
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3: R.B. Seth, et al.; Cell 122, 669 (2005) Abstract
CARD games between virus and host get a new player: C.L. Johnson and M. Gale, Jr.; Trends Immunol. 27, 1 (2006) Abstract
Further Categories Containing This Product:
NF-kB Pathway Other Products • Caspase Recruitment Domain [CARD] Proteins/Related Products • Polyclonal Antibodies
 
 
ALX-210-932 Revised 28-Feb-07
Polyclonal Antibody to RIG-I (human) (AT111)
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SYNONYMS anti-RIG-1 (human) PAb (AT111)
anti-Retinoic Acid-inducible Ge