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ALX-210-873
Revised 02-Jun-08
Polyclonal Antibody to Toll-like Receptor 6
SYNONYMS
anti-TLR6 PAb
anti-CD286 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-873-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to a portion of mouse TLR6 (Toll-like receptor 6).
SPECIFICITY:
Recognizes human and mouse TLR6. Detects a band of ~92kDa by Western blot.
APPLICATION:
Flow Cytometry (2µg/10
6
cells)
Western blot (1-2µg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract:
M.A. Palladino, et al; Biol. Reprod.
76
, 958 (2007)
Abstract
General Information
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. The aa sequence of human TLR6 is most similar to hTLR1 with 69% identity at the aa level. Human TLR6 consists of a predicted 807 aa with a molecular weight of approximately 92 kDa. Human and mouse TLR6 share an aa identity of 73%. TLR6 activates both NF-κB and c-Jun N-terminal Kinase (JNK). The aa in the cytoplasmic domain of IL-1 receptor, which are critical for NF-κB activation, are conserved in TLR6. It has also been shown that TLR2-mediated response to a phenol-soluble factor from staphylococcus epidermidis is enhanced by TLR6. TLR6 is predominantly expressed in spleen, thymus, ovary, and lung.
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-874
Revised 13-May-08
Polyclonal Antibody to Toll-like Receptor 7
SYNONYMS
anti-TLR7 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-874-C100
100 µg
293.00 USD
ALX-210-874PF-C100
Preservative Free
100 µg
319.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
ALX-210-874
: Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
ALX-210-874PF
: Liquid. In PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 706-728 of human TLR7 (Toll-like receptor 7).
SPECIFICITY:
Recognizes human and mouse TLR7.
APPLICATION:
Immunocytochemistry
(see [1])
Flow Cytometry
(intracellular (2-5µg/10
6
cells), cell surface (see [5]))
Immunohistochemistry
(frozen sections (see [4]), paraffin sections (5-10µg/ml))
Immunoprecipitation
(see [8])
Western Blot
(1-3µg/ml; in human Ramos cells, additional bands are seen)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1]
Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line:
M.D. Srivastava and B.I. Srivastava; Leuk. Res.
29
, 813 (2005)
Abstract
[2]
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad:
S. Francois, et al.; J. Immunol.
174
, 3633 (2005)
Abstract
[3]
TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production:
O.M. Hart, et al.; J. Immunol.
175
, 1636 (2005)
Abstract
[4]
Toll-like receptor-7 modulates immune complex glomerulonephritis:
R.D. Pawar, et al.; J. Am. Soc. Nephrol.
17
, 141 (2006)
Abstract
;
Full Text
[5]
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice:
P.S. Patole, et al.; Nephrol. Dial. Transplant.
21
, 3062 (2006)
Abstract
[6]
Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract:
M.A. Palladino, et al.; Biol. Reprod.
76
, 958 (2007)
Abstract
[7]
Antitumor effects of imidazoquinolines in urothelial cell carcinoma of the bladder:
E.B. Smith, et al.; J. Urol.
177
, 2347 (2007)
Abstract
[8]
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling:
M.M. Brinkmann, et al.; J. Cell Biol.
177
, 265 (2007)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-639
Revised 16-Oct-07
Polyclonal Antibody to Toll-like Receptor 8
SYNONYMS
anti-TLR8 PAb
anti-CD288 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-639-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From goat.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 81-109 (CE
81
SFQGLQNLTKINLNHNPNVQHQNGNPGI
109
) of the N-terminal domain of human TLR8 (Toll-like receptor 8).
SPECIFICITY:
Recognizes human and mouse TLR8.
APPLICATION:
Immunocytochemistry (acetone fixed cells (>1:400))
Immunohistochemistry (paraffin sections (>1:250))
Western Blot (>1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-168-015
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-168-015
Blocking Peptide for PAb to Toll-like Receptor 8 (Prod. No.
ALX-210-639
)
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-368
Revised 30-Oct-07
Polyclonal Antibody to Toll-like Receptor 9
SYNONYMS
anti-TLR9 PAb
anti-CD289 PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-368-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 275-291 of mouse TLR9 (Toll-like receptor 9) (extracellular domain).
SPECIFICITY:
Recognizes human and mouse TLR9. Detects a band of ~113kDa by Western blot.
APPLICATION:
Flow Cytometry (intracellular (1-2µg/10
6
))
Flow Cytometry (cell surface (see [6]))
Immunocytochemistry (see [5])
Immunocytochemistry (paraffin sections (see [8]); frozen sections (10µg/ml) (see [6]))
Western Blot (0.5-1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1]
Toll-like receptor 9 regulates tumor necrosis factor-alpha expression by different mechanisms. Implications for osteoclastogenesis:
A. Amcheslavsky, et al.; J. Biol. Chem.
279
, 54039 (2004)
Abstract
;
Full Text
[2]
IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA:
M. Uchijima, et al.; Immunol. Cell Biol.
83
, 92 (2005)
Abstract
[3]
Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects:
I.N. Buhtoiarov, et al.; J. Immunol.
176
, 309 (2006)
Abstract
;
Full Text
[4]
Distinct responses of lung and spleen dendritic cells to the TLR9 agonist CpG oligodeoxynucleotide:
L. Chen, et al.; J. Immunol.
177
, 2373 (2006)
Abstract
;
Full Text
[5]
Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity:
M.A. Merrell, et al.; Mol. Cancer Res.
4
, 437 (2006)
Abstract
;
Full Text
[6]
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice:
P.S. Patole, et al.; Nephrol. Dial. Transplant.
21
, 3062 (2006)
Abstract
[7]
Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro:
J.M. Ilvesaro, et al.; Prostate
67
, 774 (2007)
Abstract
[8]
Toll-like receptor 9 expression in murine and human adrenal glands and possible implications during inflammation:
N. Tran, et al.; ; J. Clin. Endocrinol. Metab.
92
, 2773 (2007)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-642
Revised 12-Oct-07
Polyclonal Antibody to Toll-like Receptor 9 (human)
SYNONYMS
anti-TLR9 (human) PAb
anti-CD289 (human) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-642-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From goat.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 205-233 (CS
205
LKYNNLTVVPRNLPSSLEYLLLSYNRIVKL
235
) of the N-terminal domain of human TLR9 (Toll-like receptor 9).
SPECIFICITY:
Recognizes human TLR9. Cross-reacts with mouse TLR9.
APPLICATION:
Immunocytochemistry (acetone fixed cells (>1:400))
Immunohistochemistry (paraffin sections (>1:250))
Western Blot (>1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-168-016
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-168-016
Blocking Peptide for PAb to to Toll-like Receptor 9 (human) (Prod. No.
ALX-210-642
)
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-637
Revised 12-Oct-07
Polyclonal Antibody to Toll-like Receptor 9 (mouse)
SYNONYMS
anti-TLR9 (mouse) PAb
anti-CD289 (mouse) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-637-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From goat.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 204-224 (L
204
SLKYNNLTKVPRQLPPSLEY
224
C) of the N-terminal domain of mouse TLR9 (Toll-like receptor 9).
SPECIFICITY:
Recognizes mouse TLR9. Cross-reacts with human TLR9.
APPLICATION:
Immunocytochemistry (acetone fixed cells (>1:400))
Immunohistochemistry (paraffin sections (>1:250))
Western Blot (>1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-168-013
.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-643
Revised 23-Oct-07
Polyclonal Antibody to Toll-like Receptor 10 (human)
SYNONYMS
anti-TLR10 (human) PAb
anti-CD290 (human) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-643-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From goat.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope affinity-purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 81-111 (CH
81
NRIQQLDLKTFEFNKELRYLDLSNNRLKSV
111
) of human TLR10 (Toll-like receptor 10).
SPECIFICITY:
Recognizes human TLR10.
APPLICATION:
Immunocytochemistry (acetone fixed cells (1:400))
Immunohistochemistry (paraffin sections (>1:250))
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-168-017
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-168-017
Blocking Peptide for PAb to Toll-like Receptor 10 (Prod. No.
ALX-210-643
)
ALX-804-407
Monoclonal Antibody to Toll-like Receptor 10 (human) (158C1114)
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-215-014
Revised 30-Oct-07
Polyclonal Antibody to Toll-like Receptor 10 (mouse/rat)
SYNONYMS
anti-TLR10 (mouse/rat) PAb
anti-CD290 (mouse/rat) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-014-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Mixture of 3 synthetic peptides corresponding to aa 37-52 (M
37
SLRKVPADLTPATTT
52
), aa 235-251 (R
235
NLSLENAKTSVLLLNK
251
) and aa 393-409 (F
393
ANNTPLEHLDLSQNLL
409
) of human TLR10 (Toll-like receptor 10).
SPECIFICITY:
Recognizes mouse and rat TLR10. By ELISA strongly detects aa 37-52, weakly detects aa 235-251 and 392-409. For detection of human TLR10 use MAb to Toll-like Receptor 10 (human) (158C1114) (Prod. No.
ALX-804-407
).
APPLICATION:
ELISA (1:100-1’000)
Western Blot (5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-804-407
Monoclonal Antibody to Toll-like Receptor 10 (human) (158C1114)
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-215-013
Revised 01-Nov-07
Polyclonal Antibody to Toll-like Receptor 11 (mouse)
SYNONYMS
anti-TLR11 (mouse) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-013-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 911-926 (C
911
EQLKRRLSKAGQERD
926
) of mouse TLR11 (Toll-like receptor 11).
SPECIFICITY:
Recognizes mouse TLR11.
APPLICATION:
Western Blot (1-3µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-215-012
Revised 01-Nov-07
Polyclonal Antibody to Toll-like Receptor 12 (mouse)
SYNONYMS
anti-TLR12 (human) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-012-C100
100 µg
384.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
