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ALX-151-035
Revised 22-Jul-08
Ac-muramyl-Ala-D-Glu-amide
SYNONYMS
MDP-LD
N-Acetylmuramyl-L-alanyl-D-isoglutamine
Adjuvant Peptide
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Nod-complex / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-151-035-M001
1 mg
35.00 USD
ALX-151-035-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
19
H
32
N
4
O
11
MW:
492.5
CAS NUMBER:
53678-77-6
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (TLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
After reconstitution, prepare aliquots and store at -20°C.
Product Description
Specific ligand for NALP3. For inactive control compound see MDP-DD (Prod. No.
ALX-151-036
).
Product Specific Literature References
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives:
F. Ellouz, et al.; Biochem. Biophys. Res. Commun.
59
, 1317 (1974)
Abstract
Further Categories Containing This Product:
Peptides
ALX-151-036
Revised 22-Aug-07
Ac-muramyl-D-Ala-D-Glu-amide
SYNONYMS
MDP-DD
N-Acetylmuramyl-D-alanyl-D-isoglutamine
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Nod-complex / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-036-M001
1 mg
70.00 USD
ALX-151-036-M005
5 mg
240.00 USD
Product Specification
FORMULA:
C
19
H
32
N
4
O
11
MW:
492.5
SOURCE/HOST:
Synthetic.
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inactive control compound for MDP-LD (Prod. No.
ALX-151-035
).
Product Specific Literature References
Muramyl peptides: immunomodulators, sleep factors, and vitamins:
A. Adam and E. Lederer; Med. Res. Rev.
4
, 111 (1984)
Abstract
ALX-803-302
Revised 06-Aug-07
Monoclonal Antibody to CHP1 (5E9G5)
SYNONYMS
anti-CHORD Containing Protein-1 MAb (5E9G5)
anti-CHORDC1 MAb (5E9G5)
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Cell Stress, Oxidative Stress & Redox Signalling Other Products
Ordering Information
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ALX-803-302-C100
100 µg
240.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
5E9G5
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.2mg/ml
PURITY:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
PURITY DETAIL:
Protein A-affinity purified.
IMMUNOGEN:
Recombinant mouse CHP1 (CHORD containing protein-1).
SPECIFICITY:
Recognizes human and mouse CHP1.
APPLICATION:
ELISA
Immunocytochemistry (5µg/ml)
Immunohistochemistry (5µg/ml)
Immunoprecipitation (5µg per 5x10
6
cells)
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Literature References
Chp-1 and melusin, two CHORD containing proteins in vertebrates:
M. Brancaccio, et al.; FEBS Lett.
551
, 47 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products
•
Nod-complex / Related Products
•
Monoclonal Antibodies
ALX-804-848
Revised 24-May-07
Monoclonal Antibody to IPAF (human) (Luna-1)
SYNONYMS
anti-Ice Protease-activating Factor (human) (Luna-1)
anti-CARD12 (human) (Luna-1)
anti-Caspase Recruitment Domain-containing Protein 12 (human) (Luna-1)
anti-CLAN (human) (Luna-1)
anti-CARD, LRR, and NACHT-containing Protein (human) (Luna-1)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Nod-complex / Related Products
Ordering Information
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Format:
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ALX-804-848-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Luna-1
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human IPAF (ice protease-activating factor) (aa 753-1024).
SPECIFICITY:
Recognizes human IPAF.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Inflammatory caspases and inflammasomes: master switches of inflammation:
F. Martinon and J. Tschopp; Cell Death Differ.
14
, 10 (2007)
Abstract
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Monoclonal Antibodies
ALX-803-307
Revised 28-Jul-08
Monoclonal Antibody to Nod2 (human) (2D9)
SYNONYMS
anti-CARD15 (human) MAb (2D9)
anti-Caspase Recruitment Domain-containing Protein 15 (human) MAb (2D9)
anti-Ibd1 (human) MAb (2D9)
anti-Inflammatory Bowel Disease Protein 1 (human) PAb (2D9)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Nod-complex / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-803-307-1
1 Vial
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
2D9
ISOTYPE:
Mouse IgG1κ
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Affinity-purified.
FORMULATION:
Liquid. In 200μl PBS, pH 7.2, containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human Nod2 (CARD15) (aa 28-301).
SPECIFICITY:
Recognizes human Nod2.
APPLICATION:
Immunohistochemistry (2µg/ml)
Immunoprecipitation
Western Blot (transfected cells: 1:100 - 1:250)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least one year after receipt when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Literature References
Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB
:
J. Bertin, et al.; J. Biol. Chem.
274
, 12955 (1999)
Abstract
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
:
N. Inohara, et al. ; J. Biol. Chem.
274
, 14560 (1999)
Abstract
An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways
:
N. Inohara, et al. ; J. Biol. Chem.
275
, 27823 (2000)
Abstract
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
:
Y. Ogura, et al.; J. Biol. Chem.
276
, 4812 (2001)
Abstract
Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation
:
O. Gutierrez, et al. ; J. Biol. Chem.
277
, 41701 (2001)
Abstract
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
:
Y. Ogura, et al. ; Nature
411
, 603 (2001)
Abstract
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
:
J.P. Hugot, et al. ; Nature
411
, 599 (2001)
Abstract
Human Nod1 confers responsiveness to bacterial lipopolysaccharides
:
N. Inohara, et al. ; J. Biol. Chem.
276
, 2551 (2001)
Abstract
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis
:
Y. Ogura, et al. ; Gut
52
, 1591 (2003)
Abstract
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Monoclonal Antibodies
ALX-804-139
Revised 09-May-07
Monoclonal Antibody to RIP2 (human) (Nick-1)
SYNONYMS
anti-Receptor-interacting Protein 2 (human) MAb (Nick-1)
anti-CARDIAK (human) MAb (Nick-1)
anti-CARD-containing Interleukin-1β Converting Enzyme Associated Kinase (human) MAb (Nick-1)
anti-RICK (human) MAb (Nick-1)
anti-RIPK2 (human) MAb (Nick-1)
anti-Receptor-interacting Serine/Threonine Protein Kinase 2 (human) MAb (Nick-1)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
RIP Kinases
Ordering Information
Product Numbers:
Format:
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ALX-804-139-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Nick-1
ISOTYPE:
Rat IgG2a
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RIP2 (receptor-interacting protein 2) (aa 1-322).
SPECIFICITY:
Recognizes human RIP2.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-604
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Participation of Rip2 in LPS signaling is independent of its kinase activity
:
C. Lu, et al.; J. Biol. Chem.
280
, 16278 (2005)
Abstract
;
Full Text
PIDD mediates NF-kB activation in Response to DNA damage:
Janssens, et al.; Cell
123
, 1079 (2005)
Abstract
Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity:
C. Lu, et al.; J. Biol. Chem.
280
, 16278 (2005)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Nod-complex / Related Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Monoclonal Antibodies
ALX-210-918
Revised 24-Sep-08
Polyclonal Antibody to Nod1 (human) (AL184)
SYNONYMS
anti-CARD4 (human) PAb (AL184)
anti-Caspase Recruitment Domain-containing Protein 4 (human) PAb (AL184)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Nod-complex / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-210-918-C050
50 µg
194.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 2-31 (E
2
EQGHSEMEIIP
SESHPHIQLLKSNRELLV
31
) of human Nod1 [CARD4].
SPECIFICITY:
Recognizes human Nod1.
APPLICATION:
Western blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
NOD protein expression and function in first trimester trophoblast cells:
M.J. Costello, et al.; Am. J. Reprod. Immunol.
57
, 67 (2007)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition
:
T. Tanabe, et al.; EMBO J.
23
, 1587 (2004)
Abstract
Further Categories Containing This Product:
Adaptor Proteins for Death Receptors Other Products
•
Polyclonal Antibodies
ALX-210-373
Revised 02-Apr-07
Polyclonal Antibody to Nod2 (human)
SYNONYMS
anti-CARD15 (human) PAb
anti-Caspase Recruitment Domain-containing Protein 15 (human) PAb
anti-Ibd1 (human) PAb
anti-Inflammatory Bowel Disease Protein 1 (human) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Nod-complex / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-373-1
1 Vial
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with 100µl water containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human Nod2 (CARD15) (aa 28-301).
SPECIFICITY:
Recognizes human Nod2.
APPLICATION:
Immunoprecipitation*
Western Blot (1:500 to 1:1'000)*
*) tested with cells overexpressing Nod2. In monocytes, Nod2 is expressed at low levels and may not be detected with this antibody.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution store at +4°C.
Further Categories Containing This Product:
Polyclonal Antibodies
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
ALX-840-604
Revised 01-Mar-07
Positive Control (Cell Lysate) for Antibodies to RIP2 (human)
SYNONYMS
Positive Control (Cell Lysate) for Antibodies to Receptor-interacting Protein 2 (human)
Positive Control (Cell Lysate) for Antibodies to CARDIAK (human)
Positive Control (Cell Lysate) for Antibodies to CARD-containing IL-1β Converting Enzyme Associated Kinase (human)
Positive Control (Cell Lysate) for Antibodies to RICK (human)
Positive Control (Cell Lysate) for Antibodies to RIPK2 (human)
Positive Control (Cell Lysate) for Antibodies to Receptor-interacting Serine-Threonine Kinase 2 (human)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Positive Controls (Cell Lysates & Extracts)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-840-604-R100
100 µl
70.00 USD
Product Specification
SOURCE/HOST:
Whole cell lysate of HEK 293T cells transfected with an expression plasmid for human RIP2 (receptor-interacting protein 2) (aa 1-541) fused at the C-terminus to a FLAG
®
-tag.
QUANTITY:
100µl corresponding to 2x10
6
cells.
FORMULATION:
Liquid. In 5x sample buffer (312.5mM TRIS, pH 6.8, containing 10% SDS, 6% glycerol, 0.075% bromophenol blue, 10% β-mercaptoethanol and 10mM DTT).
APPLICATION:
Positive control in Western blot for MAb to RIP2 (human) (Nick-1) (Prod. No.
ALX-804-139
). Add 13µl sterile water and 2µl DTT (100mM) to 5µl of cell lysate.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Nod-complex / Related Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
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