ALEXIS Biochemicals: Tryptanthrin

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ALX-350-028

Revised 21-May-08

Curcumin (high purity)
SYNONYMS	1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Diferuloylmethane
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products for Inflammation Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-028-M010		10 mg	15.00 USD
ALX-350-028-M050		50 mg	60.00 USD
ALX-350-028-M250		250 mg	240.00 USD

Product Specification

FORMULA:	C₂₁H₂₀O₆
MW:	368.4
CAS NUMBER:	458-37-7
MERCK INDEX:	14: 2673
SOURCE/HOST:	Isolated from turmeric (Curcuma longa).
PURITY:	≥98.5% (Note: This highly purified product does not contain 30-40% bioactive impurities)
APPEARANCE:	Orange-yellow crystalline powder.
SOLUBILITY:	Soluble in acetic acid or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.

Product Description

Dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase. Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells.

Product Specific Literature References

Modification of certain inflammation-induced biochemical changes by curcumin: R. Srivastava & R.C. Srimal; Indian J. Med. Res. 81, 215 (1985) Abstract
Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones: D.L. Flynn, et al.; Prostagl. Leukotr. Med. 22, 357 (1986) Abstract
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells: L. Korutla & R. Kumar; Biochim. Biophys. Acta 1224, 597 (1994) Abstract
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages: I. Brouet & H. Okshima; BBRC 206, 533 (1995) Abstract
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin: J.N. Commandeur & N.P. Vermeulen; Xenobiotica 26, 667 (1996) Abstract
Nitric oxide scavenging by curcuminoids: Sreejayan & M.N. Rao; J. Pharm. Pharmacol. 49, 105 (1997) Abstract
Inhibitory effects of curcumin on tumorigenesis in mice: M.T. Huang, et al.; J. Cell. Biochem. (Suppl.) 27, 26 (1997) Abstract
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties: M.M. Chan, et al.; Biochem. Pharmacol. 55, 1955 (1998) Abstract
Effect of curcumin on the production of nitric oxide by cultured rat mammary gland: M. Onoda & H. Inano; Nitric Oxide 4, 505 (2000) Abstract
Suppression of nitric oxide oxidation to nitrite by curcumin is due to the sequestration of the reaction intermediate nitrogen dioxide, not nitric oxide: B.D. Johnston & E.G. DeMaster; Nitric Oxide 8, 231 (2003) Abstract
Biological properties of curcumin-cellular and molecular mechanisms of action: B. Joe, et al.; Crit. Rev. Food Sci. Nutr. 44, 97 (2004), (Review) Abstract
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects: M.E. Egan, et al.; Science 304, 600 (2004) Abstract
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin: P. Tsvetkov, et al.; PNAS 102, 5535 (2005) Abstract
Immunomodulatory effects of curcumin: V.S. Yadav, et al.; Immunopharmacol. Immunotoxicol. 27, 485 (2005) Abstract
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases: S. Bengmark; JPEN J. Parenter. Enteral. Nutr. 30, 45 (2006), (Review) Abstract
Curcumin is an inhibitor of p300 histone acetylatransferase: M.G. Marcu, et al.; Med. Chem. 2, 169 (2006) Abstract
Multiple biological activities of curcumin: a short review: R.K. Maheshwari, et al.; Life Sci. 78, 2081 (2006), (Review) Abstract
Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1: M.K. Bae, et al.; Oncol. Rep. 15, 1557 (2006) Abstract
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells: Z. Wang, et al.; Cancer 106, 2503 (2006) Abstract
Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species: M. Panchatcharam, et al.; Mol. Cell Biochem. 290, 87 (2006) Abstract
Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia: K.K. Jung, et al.; Life Sci. 79, 2022 (2006) Abstract
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats: T. Morimoto, et al.; J. Clin. Invest. 118, 868 (2008) Abstract; Full Text

Further Categories Containing This Product:

Other Natural Products for Cancer Research • Natural Products - Protein Kinase Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • COX Inhibitors • Lipoxygenases/Related Products • EGFR Kinase Inhibitors • Glutathione S-Transferase • Respiratory Chain Other Products • Active Substances from Fruit and Vegetables • Natural Products - Antioxidants • Natural Products - Apoptosis Inducers & Inhibitors

ALX-270-312

Revised 03-Jan-08

Formononetin (high purity)
SYNONYMS	7-Hydroxy-4’-methoxyisoflavone (high purity) 7-Hydroxy-3-(4’-methoxyphenyl)-4H-benzopyran-4-one (high purity)
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonoids/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-312-M005		5 mg	140.00 USD

Product Specification

FORMULA:	C₁₆H₁₂O₄
MW:	268.3
CAS NUMBER:	485-72-3
MERCK INDEX:	14: 4244
PURITY:	≥97%
APPEARANCE:	White to greyish powder.
SOLUBILITY:	Soluble in DMSO (200mg/ml) or methanol (2mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Place in a desiccator under vacuum for 48 hours before use.
HANDLING:	Protect from light.

Product Description

Interacts with human estrogen receptors with low potency. Enhances IL-4 production in a dose-dependent manner. Inhibits lecithin peroxidation induced by hydroxyl radicals. Selective inhibitor of the γ-isoform of alcohol dehydrogenase. Antioxidant.

Product Specific Literature References

Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor: R.J. Miksicek; J. Steroid Biochem. Mol. Biol. 49, 153 (1994) Abstract
Dietary estrogenic isoflavones are potent inhibitors of beta-hydroxysteroid dehydrogenase of P. testosteronii: W.M. Keung; BBRC 215, 1137 (1995) Abstract
Proliferative response of mammary glandular tissue to formononetin: W. Wang, et al.; Nutr. Cancer 23, 131 (1995) Abstract
Antioxidant activity of phytoestrogenic isoflavones: M.B. Ruiz-Larrea, et al.; Free Radic. Res. 26, 63 (1997) Abstract
Inhibitory effects of isoflavones on lipid peroxidation by reactive oxygen species: S. Toda and Y. Shirataki; Phytother. Res. 13, 163 (1999) Abstract
Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells: B.L. Pool-Zobel, et al.; Carcinogenesis 21, 1247 (2000) Abstract
Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates: X. Jia, et al.; J. Pharmacol. Exp. Ther. 310, 1103 (2004) Abstract
Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity: J. Park, et al.; Immunology 116, 71 (2005) Abstract

Further Categories Containing This Product:

Other Natural Products for Inflammation Research • Interleukins Other Products • Active Substances from Fruit and Vegetables • Estrogen & Estrogen Receptors/Related Products • Natural Products - Antioxidants

ALX-350-086

Revised 08-Apr-08

Nordihydroguaiaretic acid
SYNONYMS	NDGA 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products for Inflammation Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-086-G001		1 g	62.00 USD

Product Specification

FORMULA:	C₁₈H₂₂O₄
MW:	302.4
CAS NUMBER:	500-38-9
MERCK INDEX:	14: 6693
SOURCE/HOST:	Synthetic.
PURITY:	≥95%
APPEARANCE:	Crystalline powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol or acetone; slightly soluble in hot water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Antioxidant and antineoplastic. Lipoxygenase inhibitor. Stimulates the rapid retrograde movement of both Golgi stacks and the trans-Golgi network to the endoplasmatic reticulum (ER). Displays pleiotropic effects on cells, which include apoptosis, cell proliferation, differentiation and chemotaxis. Anticancer agent.

Product Specific Literature References

Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid: M. Pavani, et al.; Biochem. Pharmacol. 48, 1935 (1994) Abstract
Nordihydroguaiaretic acid blocks protein transport in the secretory pathway causing redistribution of Golgi proteins into the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 273, 3068 (1998) Abstract; Full Text
Effect of nordihydroguaiaretic acid on the secretion of lipoprotein lipase: S.M. Kim, et al.; J. Biochem. Mol. Biol. 35, 518 (2002) Abstract; Full Text
Mechanisms underlying the activation of large conductance Ca2+-activated K+ channels by nordihydroguaiaretic acid: H. Yamamura, et al.; Jpn. J. Pharmacol. 89, 53 (2002) Abstract
Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid: T. Fujiwara, et al.; BBRC 301, 927 (2003) Abstract
Stepwise dissection of the intracellular fate of cationic cell-penetrating peptides: R. Fischer, et al.; J. Biol. Chem. 279, 12625 (2004) Abstract; Full Text
The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling: C.A. Culver, et al.; Life Sci. 77, 2457 (2005) Abstract
Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs: E. Floriano-Sanchez, et al.; Free Radic. Res. 40, 523 (2006) Abstract
Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells: K. Arasaki, et al.; Mol. Pharmacol. 71, 454 (2007) Abstract
Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro: Y.H. Siddique, et al.; J. Environ. Biol. 28, 279 (2007) Abstract

Further Categories Containing This Product:

Golgi Apparatus • Antitumor Agents (Enzyme Inhibitors) • Lipoxygenases/Related Products • Natural Products - Antioxidants • Natural Products - Antitumor Reagents

ALX-350-258

Revised 08-Apr-08

Parthenolide
SYNONYMS	(1aR-[1aR,4E,7aS,-10aS,-10bR])-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclo deca[1,2-b]furan-9(1aH)-one
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-258-M005		5 mg	15.00 USD
ALX-350-258-M025		25 mg	30.00 USD

Product Specification

FORMULA:	C₁₅H₂₀O₃
MW:	248.3
CAS NUMBER:	20554-84-1
MERCK INDEX:	14: 7048
RTECS:	LY4220000
SOURCE/HOST:	Isolated from feverfew leaves.
PURITY:	≥99% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (100mg/ml), dichloromethane (50mg/ml) or 100% ethanol (20mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Sesquiterpene lactone. Anti-inflammatory compound. Specifically inhibits activation of NF-κB by preventing the degradation of IκBα and IκBβ. Inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B₄ and thromboxane B₂. Potent anticancer agent. Induces apoptosis in various cancer cell lines. Specifically inhibits histone deacetylase 1 (HDAC1) without affecting other class I/II HDACs. Inhibits tubulin carboxypeptidase (TCP) activity.

Product Specific Literature References

A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro: W.A. Groenewegen & S. Heptinstall; J. Pharm. Pharmacol. 42, 553 (1990) Abstract
Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta: R.W. Barsby, et al.; J. Pharm. Pharmacol. 44, 737 (1992) Abstract
Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components: H. Sumner, et al.; Biochem. Pharmacol. 43, 2313 (1992) Abstract
Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases: D. Hwang, et al.; BBRC 226, 810 (1996) Abstract
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta: S.P. Hehner, et al.; J. Biol. Chem. 273, 1288 (1998) Abstract
Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells: H.R. Wong & I.Y. Menendez; BBRC 262, 375 (1999) Abstract
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF- kappa B by targeting the I kappa B kinase complex: S.P. Hehner, et al.; J. Immunol. 163, 5617 (1999) Abstract
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide: N.M. Patel, et al.; Oncogene 19, 4159 (2000) Abstract
Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase: H. Nakshatri, et al.; Oncogene 23, 7330 (2004) Abstract
Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis: S. Zhang, et al.; Cancer Lett. 211, 175 (2004) Abstract
Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity: W. Wang, et al.; Apoptosis 11, 2225 (2006) Abstract
Parthenolide inhibits tubulin carboxypeptidase activity: X. Fonrose, et al.; Cancer Res. 67, 3371 (2007) Abstract
Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated: Y.N. Gopal, et al.; Chem. Biol. 14, 813 (2007) Abstract

Further Categories Containing This Product:

COX Inhibitors • MAPK Pathway Inhibitors • NF-kB Pathway Inhibitors • Natural Products - NF-kB Pathway Inhibitors • Other Natural Products for Inflammation Research • Natural Products - Apoptosis Inducers & Inhibitors

ALX-350-299

Revised 25-May-07

S14-95
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products for Inflammation Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-299-MC05		0.5 mg	250.00 USD

Product Specification

FORMULA:	C₂₈H₃₄O₅
MW:	450.6
SOURCE/HOST:	Isolated from Penicillium sp.
PURITY:	≥95% (HPLC)
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C

Product Description

Potent inhibitor of cytokine-induced activation of STAT1α leading to the inhibition of inducible expression of proinflammatory enzymes (COX-2, iNOS (NOS II)) and cytokines (TNF-α).

Product Specific Literature References

S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species: G. Erkel, et al.; J. Antibiot. 56, 337 (2003) Abstract
Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi: Y. Yao, et al.; Mol. Pharmacol. 63, 383 (2003) Abstract; Full Text

Further Categories Containing This Product:

COX Inhibitors • NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • MAPK Pathway Inhibitors • Natural Products - Protein Kinase Inhibitors

ALX-350-339

Revised 14-Nov-07

Thielavin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products for Inflammation Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-339-MC05		0.5 mg	390.00 USD

Product Specification

FORMULA:	C₂₉H₃₀O₁₀
MW:	538.5
CAS NUMBER:	71950-66-8
SOURCE/HOST:	Isolated from an unidentified fungus MST-FP1888.
PURITY:	≥94% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Fungal metabolite. Glucose-6-phosphatase inhibitor. Inhibitor of prostaglandin biosynthesis.

Product Specific Literature References

Thielavin A and B, new inhibitors of prostaglandin biosynthesis produced by Thielavia terricola: N. Kithahara, et al.; J. Antibiot. (Tokyo) 34, 1562 (1981) Abstract
The structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi: N. Kithahara, et al.; J. Antibiot. (Tokyo) 36, 599 (1983) Abstract
Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus: N. Mani, et al.; J. Antibiot. (Tokyo) 51, 471 (1998) Abstract
Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activities: S. Sakemi, et al.; J. Antibiot. (Tokyo) 55, 941 (2002) Abstract

Further Categories Containing This Product:

Glycobiology Other Products • Prostaglandin Synthases/Related Products

ALX-350-340

Revised 14-Nov-07

Thielavin B
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products for Inflammation Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-340-MC05		0.5 mg	390.00 USD

Product Specification

FORMULA:	C₃₁H₃₄O₁₀
MW:	566.6
CAS NUMBER:	71950-67-9
SOURCE/HOST:	Isolated from an unidentified fungus MST-FP1888.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Fungal metabolite. Glucose-6-phosphatase inhibitor. Potent inhibitor of phospholipase C. Inhibits telomerase, viral reverse transcriptase, peptidoglycan formation and prostaglandin biosynthesis.

Product Specific Literature References

Thielavin A and B, new inhibitors of prostaglandin biosynthesis produced by Thielavia terricola: N. Kitahara, et al.; J. Antibiot. (Tokyo) 34, 1562 (1981) Abstract
The structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi: N. Kitahara, et al.; J. Antibiot. (Tokyo) 36, 599 (1983) Abstract
Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus: N. Mani, et al.; J. Antibiot. (Tokyo) 51, 471 (1998) Abstract
Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B: K. Togashi, et al.; Biosci. Biotechnol. Biochem. 65, 651 (2001) Abstract; Full Text
Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activitie: S. Sakemi, et al.; J. Antibiot. (Tokyo) 55, 941 (2002) Abstract

Further Categories Containing This Product:

Phospholipase C/Related Products • Telomerase/Related Products • Prostaglandin Synthases/Related Products

ALX-350-261

Revised 08-Apr-08

Trichodion
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products - DNA Regulation/Transcription

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-261-C100		100 µg	85.00 USD
ALX-350-261-C500		500 µg	250.00 USD

Product Specification

FORMULA:	C₁₂H₁₄O₅
MW:	238.2
SOURCE/HOST:	Isolated from Trichosporiella sp.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	CYTOTOXIC.

Product Description

Inhibits NF-κB (IC₅₀=42-84µM), AP-1 (IC₅₀=21µM) and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS ll) expression.

Product Specific Literature References

Trichodion, a new inhibitor of inflammatory signal transduction pathways from a Trichosporiella species: G. Erkel; FEBS Lett. 477, 219 (2000) Abstract; Full Text
Trichodion, a new bioactive pyrone from a Trichosporiella species: G. Erkel, et al.; J. Antibiot. (Tokyo) 53, 1401 (2000) Abstract

Further Categories Containing This Product:

COX Inhibitors • NOS Inhibitors (NOS Induction & Enzyme Activity) • NF-kB Pathway Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Other Natural Products for Inflammation Research

ALX-270-360

Revised 21-May-08

Tryptanthrin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products for Inflammation Research

Ordering Information

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