• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Inflammation
You are here: Product Lines > Inflammation
 
Toolbar - View Selection
 
 Items 1-100 of 673 Page 1 of 7 Select Page: 1 2 3 4 5 6 7  >>  
ALX-270-374 Revised 08-Dec-04
5-[(S)-(-)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
Add to Clipboard
SYNONYMS Caspase-7 Inhibitor
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-374-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C14H16N2O5S
MW: 324.4
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or methanol.
HANDLING: Packaged under inert gas. Protect from light.

Product Description
Potent, reversible, non-peptide inhibitor of caspase-3 (Ki=60nm), caspase-7 (Ki=170nM) and caspase-9 (Ki=3.1µM).
Product Specific Literature References
Potent and selective nonpeptide inhibitors of caspases 3 and 7: D. Lee, et al.; J. Med. Chem. 44, 2015 (2001) Abstract
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality: D. Lee, et al.; J. Biol. Chem. 275, 16007 (2000) Abstract
 
 
ALX-420-036 Revised 21-Jul-05
DICA
Add to Clipboard
SYNONYMS 2-(2,4-Dichlorophenoxy)-N-(2-mercaptoethyl)acetamide
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-036-M005   5 mg 40.00 USD Add To Cart
ALX-420-036-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C10H11Cl2NO2S
MW: 280.2
CAS NUMBER: 613665-26-2
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Do not store DMSO solutions for more than 1 day.
HANDLING: Keep under inert gas. Protect from oxygen.

Product Description
Inhibitor of caspase-3 and caspase-7 binding to an allosteric site and not to the active site.
Product Specific Literature References
Discovery of an allosteric site in the caspases: J.A. Hardy, et al.; PNAS 101, 12461 (2004) Abstract; Full Text
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-260-094 Revised 09-May-06
D2R (high purity)
Add to Clipboard
SYNONYMS (L-Asp)2 rhodamine 110 (high purity) . TFA salt
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-094-M001   1 mg 120.00 USD Add To Cart
ALX-260-094-5001   5x1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C28H24N4O9 . CF3COOH
MW: 560.5 . 114.0
PURITY: ≥98%
APPEARANCE: Off-white to orange powder.
SOLUBILITY: Soluble in DMSO.
RECONSTITUTION: Reconstitute in DMSO followed by the addition of ethanol at a ratio 1:1.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Aliquots in DMSO:ethanol (1:1) are stable for at least 1 month when stored at -20°C and stable for at least 6 months when stored at -80°C. Use high purity reagents only as the dye is instable in water. Discard surplus aqueous solutions.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light.

Product Description
Substrate for detection of intracellular caspase activation by flow cytometry and fluorescence microscopy after apoptosis induction in intact hematopoietic cell lines. For detailed application protocols see [2].
Product Specific Literature References
[1] Rhodamine 110-linked amino acids and peptides as substrates to measure caspase activity upon apoptosis induction in intact cells: H. Hug, et al.; Biochemistry 38, 13906 (1999) Abstract
[2] Fluorogenic substrates as detectors of caspase activity during natural killer cell-induced apoptosis: M. Los, et al.; Methods Mol. Biol. 121, 155 (2000) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION D2R can be used to detect caspase activity (predominantly caspase-3) in intact cells by flow cytometry [1], fluorescence microscopy as well as in cell extracts followed by analysis with a fluorometer (λex: 488nm/λem 550nm). Free (cleaved) Rhodamine 110 emits light both in the FL1 and FL2 channel. Dual staining is possible by employing the FL3 channel for flow cytometry. At least 160 assays can be performed (100µl sample volume (e.g. whole blood sample) and 100µM D2R) [2]. Optimal substrate concentrations for other applications range from 25-50µM D2R and have to be determined empirically for the particular cell system.
 
 
ALX-350-366 Revised 03-Apr-08
Azaspiracid-1
Add to Clipboard
SYNONYMS AZA-1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-366-C001   1 µg 180.00 USD Add To Cart
Product Specification
FORMULA: C47H71NO12
MW: 842.1
CAS NUMBER: 214899-21-5
SOURCE/HOST: Islolated from marine mussel.
CONCENTRATION:

2μg/ml
PURITY: ≥95%
FORMULATION: Liquid. In methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC. MAY BE TERATOGENIC.

Product Description
Activator of JNK (c-Jun-N-terminal kinase). Cellular growth inhibitor and inducer of cytoskeletal alterations. Activator of caspases. Modulator of intracellular cAMP (cyclic adenosine monophosphate) and calcium levels. Inhibitor of cholesterol biosynthesis in human T lymphocyte cells. Potent teratogen to finfish. Cytotoxic to mammalian cells.
Product Specific Literature References
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland: E. Ito, et al.; Toxicon 38, 917 (2000) Abstract
Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets: Y. Roman, et al.; Cell. Signal. 14, 703 (2002) Abstract
Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos: J.R. Coleman, et al.; Toxicon 45, 881 (2005) Abstract
Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines: M.J. Twiner, et al.; Toxicon 45, 891 (2005) Abstract
Azaspiracids modulate intracellular pH levels in human lymphocytes: A. Alfonso, et al.; BBRC 346, 1091 (2006) Abstract
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies: N. Vilarino, et al.; Chem. Res. Toxicol. 19, 1459 (2006) Abstract
The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1: C. Vale, et al.; Cell Physiol. Biochem. 20, 957 (2007) Abstract
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study: C. Vale, et al.; J. Med. Chem. 50, 356 (2007) Abstract
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells: N. Vilarino, et al.; Biochem. Pharmacol. 74, 327 (2007) Abstract
Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid: M.J. Twiner, et al.; Genomics 91, 289 (2008) Abstract
Further Categories Containing This Product:
MAPK Pathway Activators • Natural Products for Cytoskeletal Research • Natural Products - Other Signal Transduction Pathway Modulators • Caspases Other Products • cAMP Pathways Other Products
 
 
ALX-420-031 Revised 11-Jun-04
PETCM
Add to Clipboard
SYNONYMS α-(Trichloromethyl)-4-pyridineethanol
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-031-M010   10 mg 30.00 USD Add To Cart
ALX-420-031-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C8H8Cl3NO
MW: 240.5
CAS NUMBER: 10129-56-3
PURITY: ≥95%
APPEARANCE: White to brownish powder.
SOLUBILITY: Soluble in dimethyl formamide, DMSO or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. IRRITANT.
MELTINGPOINT: 164°C

Product Description
Activator of caspase-3 in cell extracts. Relieves prothymosin α inhibition and promotes apoptosome formation at a physiological concentration of deoxyadenosine triphosphate.
Product Specific Literature References
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway: X. Jiang, et al.; Science 299, 223 (2003) Abstract
Related Products
Further Categories Containing This Product:
Caspases Other Products
 
 
ALX-420-035 Revised 03-May-05
Apoptosis Activator 2
Add to Clipboard
SYNONYMS 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Apoptosis Inducers & Inhibitors Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-035-M005   5 mg 45.00 USD Add To Cart
ALX-420-035-M025   25 mg 180.00 USD Add To Cart
Inquire
Product Specification
FORMULA: C15H9NO2Cl2
MW: 306.1
CAS NUMBER: 79183-19-0
PURITY: ≥98% (NMR)
APPEARANCE: Orange to red solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Induces apoptosis by promoting the oligomerization of Apaf-1 into the mature, functional apoptosome, triggering caspase-9 activation resulting in activated caspase-3. Shows strong selectivity for cancer cells against normal cell lines. Acts in a similar way like apoptosis inducer PETCM (Prod. No. ALX-420-031).
Product Specific Literature References
Direct activation of the apoptosis machinery as a mechanism to target cancer cells: J.T. Nguyen and J.A. Wells; PNAS 100, 7533 (2003) Abstract; Full Text
Further Categories Containing This Product:
Caspases Other Products
 
 
ALX-430-146 Revised 30-Nov-06
PAC-1
Add to Clipboard
SYNONYMS 4-(Phenylmethyl)[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide-1-piperazine acetic acid
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-146-M010   10 mg 45.00 USD Add To Cart
ALX-430-146-M050   50 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C23H28N4O2
MW: 392.5
CAS NUMBER: 315183-21-2
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetonitrile, DMSO, dioxane or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
First molecule to directly activate procaspase-3 to caspase-3 in vitro. Has been shown to induce apoptosis in cancer cells.
Product Specific Literature References
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy: K.S. Putt, et al.; Nat. Chem. Biol. 2, 543 (2006) Abstract
Further Categories Containing This Product:
Caspases Other Products
 
 
ALX-340-004 Revised 18-Aug-08
Arachidonic acid
Add to Clipboard
SYNONYMS 5Z,8Z,11Z,14Z-Eicosatetraenoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Arachidonic Acid / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-004-M100   100 mg 147.00 USD Add To Cart
Product Specification
FORMULA: C20H32O2
MW: 304.5
CAS NUMBER: 506-32-1
MERCK INDEX: 14: 765
RTECS: CE6675000
CONCENTRATION: 100mg/ml
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol containing 0.1% BHT.
SOLUBILITY: 100mg/ml soluble in DMSO or dimethyl formamide; sparingly soluble in basic aqueous buffers (1.7mg/ml). To prevent oxidation, the solvent should be purged with an inert gas.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING: Protect from light and oxygen.
HAZARD: TOXIC.

Product Description
Precursor to a large family of eicosanoids. Activator for several protein kinase C (PKC) isotypes.
Product Specific Literature References
Arachidonic acid metabolism: P. Needleman, et al.; Ann. Rev. Biochem. 55, 69 (1986) Abstract
Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid: M.D. Lister, et al.; J. Biol. Chem. 263, 7506 (1988) Abstract; Full Text
Characterization of the L-arginine:nitric oxide pathway in human platelets: M.W. Radomski, et al.; Br. J. Pharmacol. 101, 325 (1990) Abstract
The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor: A.J.R. Habenicht, et al.; Nature 345, 634 (1990) Abstract
The control of free arachidonic acid levels: R.D. Burgoyne & A. Morgan; TIBS 15, 365 (1990) Abstract
A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets: F. Chevy, et al.; Lipids 26, 1080 (1991) Abstract
Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids: J.W. Han, et al.; Science 252, 576 (1991) Abstract
Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils: S.B. Abramson, et al.; J. Immunol. 147, 231 (1991) Abstract
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation: Henderson, et al.; Eur. J. Biochem. 211, 157 (1993) Abstract
Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia: G. Khurana & M.R. Bennett; Br. J. Pharmacol. 109, 480 (1993) Abstract
Arachidonic acid-induced Ca2+ release from isolated sarcoplasmic reticulum: C. Dettbarn & P. Palade; Biochem. Pharmacol. 45, 1301 (1993) Abstract
Covalent binding of arachidonate to G protein alpha subunits of human platelets: H. Hallak, et al.; J. Biol. Chem. 269, 4713 (1994) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PKC Activators • Nitric Oxide Pathway Other Products • Fatty Acids
 
 
ALX-270-086 Revised 07-May-08
Indomethacin
Add to Clipboard
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-086-G005   5 g 30.00 USD Add To Cart
ALX-270-086-G025   25 g 80.00 USD Add To Cart
Product Specification
FORMULA: C19H16ClNO4
MW: 357.8
CAS NUMBER: 53-86-1
MERCK INDEX: 14: 4968
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in acetone or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: VERY TOXIC.

Product Description
Non-steroidal anti-inflammatory and analgesic agent. Inhibits prostaglandin synthesis. Far more potent for inhibition of cyclooxygenases (COX) than for inhibition of lipoxygenases.
Product Specific Literature References
Chemical and biological studies on indomethacin, sulindac and their analogs: T.Y. Shen, et al.; Adv. Drug Res. 12, 90 (1977) Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostagl. Leukotr. Med. 13, 53 (1984) Abstract
Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production: K.M. Stevenson & E.R. Lumbers; J. Dev. Physiol. 17, 257 (1992) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • COX Inhibitors
 
 
ALX-270-097 Revised 07-Sep-06
Ebselen
Add to Clipboard
SYNONYMS 2-Phenyl-1,2-benzisoselenazol-3-(2H)-one
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY