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COX Antibodies
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ALX-804-030 Revised 30-Nov-04
Monoclonal Antibody to COX-1 (CXIII)
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SYNONYMS anti-Cyclooxygenase 1 MAb (CXIII)
anti-Prostaglandin H Synthase 1 MAb (CXIII)
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-030-1   1 Vial 412.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Monkey
Others
CLONE: CXIII
ISOTYPE: Mouse IgG2b
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 500µl distilled water. For further dilutions use any buffer suitable for your experiment.
IMMUNOGEN: Sheep seminal vesicle COX-1 (cyclooxygenase 1).
SPECIFICITY: Recognizes human, mouse, rat, monkey, sheep and bovine COX-1. Weakly cross-reacts with human (~5%) or sheep (50%) COX-2. Does not cross-react with mouse COX-2.
APPLICATION: Immunohistochemistry (frozen sections (1:50-1:100), paraffin sections (1:50-1:100)
Western Blot (1:200-1:400)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Immunological studies of human constitutive cyclooxygenase (COX-1) using enzyme immunometric assay: C. Créminon, et al.; Biochim. Biophys. Acta 1254, 333 (1995) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-485 Revised 06-Mar-07
Monoclonal Antibody to COX-2 (5E10/D10)
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SYNONYMS anti-Cyclooxygenase-2 MAb (5E10/D10)
anti-Prostaglandin H Synthase 2 MAb (5E10/D10)
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-485-C100   100 µg 420.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 5E10/D10
ISOTYPE: Mouse IgG1
CONCENTRATION: 1.9mg/ml
FORMULATION: Liquid. In PBS, pH 7.4.
IMMUNOGEN: Native purified human COX-2 (cyclooxygenase-2).
SPECIFICITY: Recognizes human and mouse COX-2. The linear epitope corresponds to the target of non steroidal anti-inflammatory drugs (NSAID). Does not cross-react with COX-1.
APPLICATION: ELISA (0.1-0.5µg/ml)
Western Blot (0.5-1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-112 Revised 18-Sep-07
Monoclonal Antibody to COX-2 (CX229)
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SYNONYMS anti-Cyclooxygenase-2 MAb (CX229)
anti-Prostaglandin H Synthase 2 MAb (CX229)
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-112-C050   50 µg 313.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Sheep
Monkey
CLONE: CX229
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml after reconstitution.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 100µl distilled water.
IMMUNOGEN: Synthetic peptide corresponding to aa 580-599 (N580ASSSRSGLDDINPTVLLKE599) of human COX-2 (cyclooxygenase 2).
SPECIFICITY: Recognizes human, monkey and sheep COX-2. Detects a band of  ~72kDa by Western blot. Expected to cross-react with bovine and dog COX-2. Does not cross-react with COX-1 or with mouse, rat or rabbit COX-2.
APPLICATION: Immunohistochemistry (1:50-1:100)
Western Blot (1:1'000)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 years when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Differential measurement of constitutive (COX-1) and inducible (COX-2) cyclooxygenase expression in human umbilical vein endothelial cells using specific immunometric enzyme immunoassays: C. Créminon, et al.; Biochim. Biophys. Acta 1254, 341 (1995) Abstract
The viral protein A238L inhibits cyclooxygenase-2 expression through a nuclear factor of activated T cell-dependent transactivation pathway: A.G. Granja, et al.; J. Biol. Chem. 279, 53736 (2004) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-709 Revised 03-Mar-05
Polyclonal Antibody to COX
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SYNONYMS anti-Cyclooxygenase PAb
anti-Prostaglandin H Synthase PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-709-1   1 Vial 233.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Sheep
SOURCE/HOST: From rabbit.
QUANTITY: Sufficient for 10 immunoblots.
FORMULATION: Lyophilized IgG fraction from rabbit antiserum.
IMMUNOGEN: Purified sheep seminal vesicle COX-1 (cyclooxygenase 1) [1].
SPECIFICITY: Recognizes mouse, rat and sheep COX-1 and COX-2.
APPLICATION: Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
[1] Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence: D.L. DeWitt & W.L. Smith; PNAS 85, 1412 (1988) Abstract
[2] Immunocytochemical localization of cyclooxygenase in the rat lens: D.R. Zheng, et al.; Invest. Ophthalmol. Vis. Sci. 33, 178 (1992) Abstract
[3] Eicosanoid metabolism in cholesterol-enriched arterial smooth muscle cells. Evidence for reduced posttranscriptional processing of cyclooxygenase I and reduced cyclooxygenase II gene expression: K.B. Pomerantz, et al.; Biochemistry 32, 13624 (1993) Abstract
[4] Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2: V. Zhang, et al.; BBRC 227, 499 (1996) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-710 Revised 10-Jul-08
Polyclonal Antibody to COX-1
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SYNONYMS anti-Cyclooxygenase 1 PAb
anti-Prostaglandin H Synthase 1 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-710-1   1 Vial 313.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Sheep
Pig
Others
SOURCE/HOST: From rabbit.
QUANTITY: 200μg lyophilized antiserum
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 200µl distilled water.
IMMUNOGEN: Synthetic peptide corresponding to aa 272-282 (L272MHYPRGIPPQ282) [1,2] of sheep seminal vesicle COX-1 (cyclooxygenase 1).
SPECIFICITY: Recognizes human, sheep and bovine endothelial COX-1. Also recognizes pig COX-1. Does not cross-react with mouse or rat COX-1 or human, mouse or sheep COX-2.
APPLICATION: Immunocytochemistry
Immunohistochemistry
Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
[1] Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence: D.L. DeWitt & W.L. Smith; PNAS 85, 1412 (1988) Abstract
[2] The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum: J.C. Otto & W.L. Smith; J. Biol. Chem. 269, 19868 (1994) Abstract; Full Text
[3] Expression of prostaglandin endoperoxide H synthase 1 and 2 in human placenta at term: L. Macchia, et al.; BBRC 233, 496 (1997) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-750 Revised 29-Jan-08
Polyclonal Antibody to COX-1
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SYNONYMS anti-Cyclooxygenase 1 PAb
anti-Prostaglandin H Synthase 1 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-750-1   1 Vial 313.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION:  
PURITY DETAIL: Affinity purified IgG.
FORMULATION: Liquid. In TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 274-288 (L274MRYPPGVPPERQMA288) of mouse COX-1 (cyclooxygenase-1).
SPECIFICITY: Recognizes mouse and rat COX-1. Does not cross-react with human or sheep COX-1 or with COX-2. Detects a band of ~70kDa by Western blot.
APPLICATION: Immunohistochemistry
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-711 Revised 06-Jan-06
Polyclonal Antibody to COX-2
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SYNONYMS anti-Cyclooxygenase 2 PAb
anti-Prostaglandin H Synthase 2 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-711-1   1 Vial 189.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Monkey
Others
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized from ~50µl purified antiserum.
RECONSTITUTION: Reconstitute with 100µl distilled water containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 584-598 (S584HSRLDDINPTVLIK598) of mouse COX-2 (cyclooxygenase 2).
SPECIFICITY: Recognizes human, mouse, rat, monkey, sheep and guinea pig COX-2. Does not cross-react with COX-1.
APPLICATION: Immunohistochemistry (frozen sections, paraffin sections; 
suggested starting dilution 1:300 -1:600)
Western Blot (1:1'000).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 years after receipt when stored at -20°C. After reconstitution store at +4°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-063.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-712 Revised 17-Apr-08
Polyclonal Antibody to COX-2
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SYNONYMS anti-Cyclooxygenase 2 PAb
anti-Prostaglandin H Synthase 2 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-712-1   1 Vial 269.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Others
SOURCE/HOST: From rabbit.
CONCENTRATION:   
FORMULATION: Liquid. In 500µl TBS, pH 8.0, containing 50% glycerol and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 567-599 (S567VPDPELIKTV
TINASSSRSGLDDINPTVLLKE599) of human COX-2 (cyclooxygenase 2).
SPECIFICITY: Recognizes human, mouse, rat, sheep and guinea pig COX-2. Does not cross-react with COX-1.
APPLICATION: Immunocytochemistry
Immunohistochemistry (frozen sections (1:300), paraffin sections (1:300))
Western Blot (1:200)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-726 Revised 19-Jun-06
Polyclonal Antibody to COX-2
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SYNONYMS anti-Cyclooxygenase 2 PAb
anti-Prostaglandin H Synthase 2 PAb
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-726-1   1 Vial 261.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Monkey
Others
SOURCE/HOST: From rabbit.
CONCENTRATION:      
PURITY DETAIL: Purified using a DEAE-Cibicron Blue column; some contaminating transferrin may be present but will not affect the experiment.
FORMULATION: Liquid. In TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to C-terminal aa 570-598 (D570PQPTKTATINASASHSRLDDINPTVLIK598) of mouse and rat COX-2 (cyclooxygenase 2).
SPECIFICITY: Recognizes human, mouse, rat, sheep, rabbit, monkey and guinea pig COX-2. Does not cross-react with COX-1.
APPLICATION: Immunocytochemistry
Immunohistochemistry (frozen sections or paraffin sections)
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years when stored at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-063.
Product Specific Literature References
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction: R.C. Harris, et al.; J. Clin. Invest. 94, 2504 (1994) Abstract
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse: S.G. Morham, et al.; Cell 83, 473 (1995) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 

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