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ALX-350-366 Revised 03-Apr-08
Azaspiracid-1
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SYNONYMS AZA-1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-366-C001   1 µg 180.00 USD Add To Cart
Product Specification
FORMULA: C47H71NO12
MW: 842.1
CAS NUMBER: 214899-21-5
SOURCE/HOST: Islolated from marine mussel.
CONCENTRATION:

2μg/ml

PURITY: ≥95%
FORMULATION: Liquid. In methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC. MAY BE TERATOGENIC.

Product Description
Activator of JNK (c-Jun-N-terminal kinase). Cellular growth inhibitor and inducer of cytoskeletal alterations. Activator of caspases. Modulator of intracellular cAMP (cyclic adenosine monophosphate) and calcium levels. Inhibitor of cholesterol biosynthesis in human T lymphocyte cells. Potent teratogen to finfish. Cytotoxic to mammalian cells.
Product Specific Literature References
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland: E. Ito, et al.; Toxicon 38, 917 (2000) Abstract
Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets: Y. Roman, et al.; Cell. Signal. 14, 703 (2002) Abstract
Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos: J.R. Coleman, et al.; Toxicon 45, 881 (2005) Abstract
Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines: M.J. Twiner, et al.; Toxicon 45, 891 (2005) Abstract
Azaspiracids modulate intracellular pH levels in human lymphocytes: A. Alfonso, et al.; BBRC 346, 1091 (2006) Abstract
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies: N. Vilarino, et al.; Chem. Res. Toxicol. 19, 1459 (2006) Abstract
The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1: C. Vale, et al.; Cell Physiol. Biochem. 20, 957 (2007) Abstract
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study: C. Vale, et al.; J. Med. Chem. 50, 356 (2007) Abstract
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells: N. Vilarino, et al.; Biochem. Pharmacol. 74, 327 (2007) Abstract
Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid: M.J. Twiner, et al.; Genomics 91, 289 (2008) Abstract
 
 
ALX-420-031 Revised 11-Jun-04
PETCM
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SYNONYMS α-(Trichloromethyl)-4-pyridineethanol
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Prothymosin alpha
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ALX-420-031-M010   10 mg 30.00 USD Add To Cart
ALX-420-031-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C8H8Cl3NO
MW: 240.5
CAS NUMBER: 10129-56-3
PURITY: ≥95%
APPEARANCE: White to brownish powder.
SOLUBILITY: Soluble in dimethyl formamide, DMSO or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. IRRITANT.
MELTINGPOINT: 164°C

Product Description
Activator of caspase-3 in cell extracts. Relieves prothymosin α inhibition and promotes apoptosome formation at a physiological concentration of deoxyadenosine triphosphate.
Product Specific Literature References
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway: X. Jiang, et al.; Science 299, 223 (2003) Abstract
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Caspases Other Products
 
 
ALX-420-035 Revised 03-May-05
Apoptosis Activator 2
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SYNONYMS 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Apoptosis Inducers & Inhibitors Other Products
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ALX-420-035-M005   5 mg 45.00 USD Add To Cart
ALX-420-035-M025   25 mg 180.00 USD Add To Cart
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Product Specification
FORMULA: C15H9NO2Cl2
MW: 306.1
CAS NUMBER: 79183-19-0
PURITY: ≥98% (NMR)
APPEARANCE: Orange to red solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Induces apoptosis by promoting the oligomerization of Apaf-1 into the mature, functional apoptosome, triggering caspase-9 activation resulting in activated caspase-3. Shows strong selectivity for cancer cells against normal cell lines. Acts in a similar way like apoptosis inducer PETCM (Prod. No. ALX-420-031).
Product Specific Literature References
Direct activation of the apoptosis machinery as a mechanism to target cancer cells: J.T. Nguyen and J.A. Wells; PNAS 100, 7533 (2003) Abstract; Full Text
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Caspases Other Products
 
 
ALX-430-146 Revised 30-Nov-06
PAC-1
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SYNONYMS 4-(Phenylmethyl)[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide-1-piperazine acetic acid
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
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ALX-430-146-M010   10 mg 45.00 USD Add To Cart
ALX-430-146-M050   50 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C23H28N4O2
MW: 392.5
CAS NUMBER: 315183-21-2
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetonitrile, DMSO, dioxane or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
First molecule to directly activate procaspase-3 to caspase-3 in vitro. Has been shown to induce apoptosis in cancer cells.
Product Specific Literature References
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy: K.S. Putt, et al.; Nat. Chem. Biol. 2, 543 (2006) Abstract
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ALX-804-264 Revised 19-Sep-05
Monoclonal Antibody to D4-GDI (cleavage-specific) (97A1015)
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SYNONYMS anti-Rho-GDI2 MAb (cleavage-specific) (97A1015)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspases Other Products
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ALX-804-264-C100   100 µg 319.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 97A1015
ISOTYPE: Mouse IgG2b
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to the region of Fas-induced cleavage site of human D4-GDI (Rho-GDI2).
SPECIFICITY: Recognizes human and mouse D4-GDI. Detects a band of ~23kDa by Western blot.
APPLICATION: Flow Cytometry (0.5-1µg/106 cells; intracellular staining)
Immunohistochemistry (2µg/ml)
Immunoprecipitation (1-2µg/ml)
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Specific Literature References
The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change: H. Yamaguchi & H.G. Wang; Oncogene 20, 7779 (2001) Abstract
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine): S. Sato, et al.; Oncogene 21, 1727 (2002) Abstract
RhoGDI2 is an invasion and metastasis suppressor gene in human cancer: J.J. Gildea, et al.; Cancer Res. 62, 6418 (2002) Abstract
Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax: S.M. Cuddeback, et al.; J. Biol. Chem. 276, 20559 (2001) Abstract; Full Text
General Literature References
Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-GDI, during apoptosis: R.J. Krieser & A. Eastman; Cell Death Differ. 6, 412 (1999) Abstract
Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling: B. Olofsson; Cell. Signal. 11, 545 (1999), (Review) Abstract
GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis: F. Essmann, et al.; Biochem. J. 346 Pt 3, 777 (2000) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 

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