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Inflammation
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ALX-380-126 Revised 17-Jul-08 New product
Asperloxine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-126-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C21H19N3O5
MW: 393.4
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Natural benzodiazepine. Anti-inflammatory.
Product Specific Literature References
Big effects from small changes: possible ways to explore nature’s chemical diversity: H.B. Bode, et al.; Chembiochem. 3, 619 (2002) Abstract
Further Categories Containing This Product:
Benzodiazepines / Related Products • Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
 
 
ALX-430-110 Revised 16-Jan-08
5-Aminosalicylic acid
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SYNONYMS 5-ASA
Mesalamine
5-Amino-2-hydroxybenzoic acid
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Inhibitors
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ALX-430-110-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C7H7NO3
MW: 153.1
CAS NUMBER: 89-57-6
MERCK INDEX: 14: 5904
PURITY: ≥98%
SOLUBILITY: Soluble in 1 M hydrochloric acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Inhibits TNF-α regulated IκB degradation and NF-κB activation.
Product Specific Literature References
Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine: S. Liptay, et al.; Br. J. Pharmacol. 128, 1361 (1999) Abstract
Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells: F. Yan & D.B. Polk; J. Biol. Chem. 274, 36631 (1999) Abstract; Full Text
Further Categories Containing This Product:
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
 
 
ALX-430-112 Revised 20-Aug-03
Phenylbutazone
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SYNONYMS 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-112-G005   5 g 10.00 USD Add To Cart
Product Specification
FORMULA: C19H20N2O2
MW: 308.4
CAS NUMBER: 50-33-9
MERCK INDEX: 14: 7277

Product Description
Anti-inflammatory agent. Substrate for prostaglandin peroxidase.
Further Categories Containing This Product:
Prostaglandins Other Products
 
 
ALX-430-116 Revised 04-Mar-05
Sodium salicylate
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-116-G005   5 g 15.00 USD Add To Cart
Product Specification
FORMULA: C7H5O3Na
MW: 160.1
CAS NUMBER: 54-21-7
MERCK INDEX: 14: 8332
PURITY: ≥99%
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Specific Literature References
Inhibition of NF-kappa B by sodium salicylate and aspirin: E. Kopp & S. Ghosh; Science 265, 956 (1994) Abstract
Neuroprotection by aspirin and sodium salicylate through blockade of NF- kappaB activation: M. Grilli, et al.; Science 274, 1383 (1996) Abstract
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta: M.J. Yin, et al.; Nature 396, 77 (1998) Abstract
The pleiotropic functions of aspirin: mechanisms of action: A.R. Amin, et al.; Cell Mol. Life Sci. 56, 305 (1999) Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
 
 
ALX-350-333 Revised 05-Apr-08
Harpagoside
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-333-M005   5 mg 90.00 USD Add To Cart
ALX-350-333-M025   25 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C24H30O11
MW: 494.5
CAS NUMBER: 19210-12-9
SOURCE/HOST: Isolated from Scrophularia ningpoensis Hemsl (Figwort).
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Anti-inflammatory and anti-diabetic compound. Suppresses LPS-induced inducible nitric oxide synthase (iNOS; NOS II) and cyclooxygenase-2 (COX-2) expression through inhibition of NF-κB activation.
Product Specific Literature References
Antiinflammatory effects of different extracts and harpagoside isolated from Scrophularia frutescens: L. D. Garcia, et al.; Farmaco. 51, 443 (1996) Abstract
Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets: S. Chrubasik, et al.; Phytomedicine 6, 469 (2000) Abstract
Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity: B. Ahmed, et al.; Biol. Pharm. Bull. 26, 462 (2003) Abstract; Full Text
Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects: M. Kaszkin, et al.; Phytomedicine 11, 585 (2004) Abstract
High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens: M. Gunther, et al.; Phytochem. Anal. 17, 1 (2006) Abstract
Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation: T.H. Huang, et al.; J. Ethnopharmacol. 104, 149 (2006) Abstract
Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study: P. Li, et al.; Anal. Bioanal. Chem. 389, 2259 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • NF-kB Pathway Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • COX Other Products • Natural Products - NF-kB Pathway Inhibitors
 
 
ALX-270-077 Revised 19-Dec-02
L-655,238
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipoxygenases / Related Products
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ALX-270-077-M005   5 mg 47.00 USD Add To Cart
Product Specification
FORMULA: C22H25NO2
MW: 335.5
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective, potent inhibitor of 5-lipoxygenase-activating protein (FLAP).
Product Specific Literature References
5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors: J.F. Evans, et al.; Mol. Pharmacol. 40, 22 (1991) Abstract
FLAP: a novel drug target for inhibiting the synthesis of leukotrienes: A.W. Ford-Hutchinson; TIPS 12, 68 (1991), (Review) Abstract
 
 
ALX-270-078 Revised 16-Jun-06
L-690,330
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SYNONYMS [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipoxygenases / Related Products
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ALX-270-078-M001   1 mg 30.00 USD Add To Cart
ALX-270-078-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C8H12O8P2
MW: 298.1
PURITY: ≥96%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Potent inositol monophosphatase inhibitor, resistant to hydrolysis.
Product Specific Literature References
In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330: J.R. Atack, et al.; J. Neurochem. 60, 652 (1993) Abstract
Further Categories Containing This Product:
Autophagy Other Products
 
 
ALX-270-099 Revised 02-Dec-04
Ethyl 3,4-dihydroxybenzylidenecyanoacetate
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipoxygenases / Related Products
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ALX-270-099-M025   25 mg 63.00 USD Add To Cart
Product Specification
FORMULA: C12H11NO4
MW: 233.2
CAS NUMBER: 132464-92-7
PURITY: ≥96%
SOLUBILITY: Soluble in DMSO and methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
12- and 15-lipoxygenase inhibitor.
Product Specific Literature References
Novel caffeic acid derivatives: extremely potent inhibitors of 12- lipoxygenase: H. Cho, et al.; J. Med. Chem. 34, 1503 (1991) Abstract
 
 
ALX-270-231 Revised 28-Feb-08
Caffeic acid
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SYNONYMS 3-(3,4-Dihydroxyphenyl)-2-propenoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-270-231-M250   250 mg 10.00 USD Add To Cart
ALX-270-231-G001   1 g 14.00 USD Add To Cart
Product Specification
FORMULA: C9H8O4
MW: 180.2
CAS NUMBER: 331-39-5
MERCK INDEX: 14: 1635
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Off-white to brown crystalline solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS, pH 7.2.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stable for at least 2 years when stored at +20°C. Organic stock solutions are stable for at least 6 months when stored at –20 °C. Store aqueous solutions of the product on ice and use within 12 hours of preparation.

Product Description

Naturally occuring phenolic compound found in many fruits, vegetables and herbs, including coffee. Shows anti-tumor, antiviral, antioxidant and anti-inflammatory effects. Inhibitor of 5- and 12-lipoxygenase (LO).
Product Specific Literature References
Caffeic acid is a selective inhibitor for leukotriene biosynthesis: Y. Koshihara, et al.; Biochim. Biophys. Acta 792, 92 (1984) Abstract
Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon: C.V. Rao, et al.; Cancer Res. 53, 4182 (1993) Abstract
Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives: N. Kohyama, et al.; Biosci. Biotech. Biochem. 61, 347 (1997) Abstract
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties: F.M. da Cunha, et al.; Free Radic. Res. 38, 1241 (2004) Abstract
Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism: T.W. Chung, et al.; FASEB J. 18, 1670 (2004) Abstract
Anti-HIV activities of natural antioxidant caffeic acid derivatives: toward an antiviral supplementation diet: F. Bailly & P. Cotelle; Curr. Med. Chem. 12, 1811 (2005) Abstract
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Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Lipoxygenases / Related Products • Tyrosine Kinase Inhibitors • Active Substances from Fruit and Vegetables • Natural Products - Antioxidants • Natural Products - Antiviral / anti-HIV Agents • Phenolic Acids
 
 
ALX-270-381 Revised 28-Sep-07
Anacardic acid
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SYNONYMS 2-Hydroxy-6-pentadecylbenzoic acid
6-Pentadecylsalicylic acid
AA
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-270-381-M005   5 mg 40.00 USD Add To Cart
ALX-270-381-M025   25 mg 140.00 USD Add To Cart
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Product Specification
FORMULA: C22H36O3
MW: 348.5
MERCK INDEX: 14: 621
SOURCE/HOST: Synthetic.
PURITY: ≥95% (1H-NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas.

Product Description
Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC50~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.
Product Specific Literature References
Anacardic Acid: molluscicide in cashew nut shell liquid: J.T. Sullivan, et al.; Planta Med. 44, 175 (1982) Abstract
Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids: R. Grazzini, et al.; BBRC 176, 775 (1991) Abstract
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi & I. Kubo; J. Appl. Bacteriol. 80, 387 (1996) Abstract
Small molecule modulators of histone acetyltransferase p300: K. Balasubramanyam, et al.; J. Biol. Chem. 278, 19134 (2003) Abstract; Full Text
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation: Y. Sun, et al.; FEBS Lett. 580, 4353 (2006) Abstract
General Literature References
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus: H. Muroi and I. Kubo; J. Appl. Bacteriol. 80, 387 (1996) Abstract
Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition: R. Paramashivappa, et al.; J. Agric. Food Chem. 50, 7709 (2002) Abstract
Further Categories Containing This Product:
Lipoxygenases / Related Products • Prostaglandin Synthases / Related Products • Antibiotics Other Products
 
 
ALX-340-008 Revised 22-May-07
7,7-Dimethyleicosadienoic acid
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SYNONYMS DEDA
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PLA2 Inhibitors
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