ALEXIS Biochemicals: Ingenol 3,20-dibenzoate

ALX-350-032

Revised 08-Oct-08

Ingenol 3,20-dibenzoate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Tumor Promoters

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-032-M001		1 mg	90.00 USD

Product Specification

FORMULA:	C₃₄H₃₆O₇
MW:	556.7
CAS NUMBER:	59086-90-7
SOURCE/HOST:	Semisynthetic.
PURITY:	≥96%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE CARCINOGENIC.

Product Description

Activates protein kinase C (PKC). Induces apoptosis. Anticancer agent. Shows potent antileukemic activity in the P388 mouse assay. Displays unusually high mouse ear inflammatory activity, even though the 20-hydroxy group is blocked with a benzoate ester. It appears likely that this high potency is due to metabolic cleavage of the 20-benzoate group, which releases the more potent ingenol 3-benzoate.

Product Specific Literature References

Antileukemic principles isolated from euphorbiaceae plants: S.M. Kupchan, et al.; Science 191, 571 (1976) Abstract
Zur Chemie des Ingcnols, II. Ester des Ingenols. und des A’-’-Isoingenols: B. Sorg & E. Hecker; Z. Naturforsch. 37b, 748 (1982)
Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation: A. Asada, et al.; J. Biol. Chem. 273, 28392 (1998) Abstract
Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway: M. Blanco-Molina, et al.; Chem. Biol. Interact. 8, 767 (2001) Abstract

Further Categories Containing This Product:

Carcinogens & Tumor Promoters Other Products • Natural Products - Antitumor Reagents • Antitumor Agents (Apoptosis Inducers) • Natural Products - Apoptosis Inducers & Inhibitors

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