ALEXIS Biochemicals: Iromycin A

ALX-380-124

Revised 20-Jun-08

Iromycin A
SYNONYMS	6-(3,7-Dimethyl-octa-2,5-dienyl)-4-hydroxy-3-methyl-5-propyl-1H-pyridin-2-one
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Nitric Oxide Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-124-MC05		0.5 mg	180.00 USD
ALX-380-124-M001		1 mg	260.00 USD
ALX-380-124-M005		5 mg	780.00 USD

Product Specification

FORMULA:	C₁₉H₂₉NO₂
MW:	303.5
SOURCE/HOST:	Isolated from Streptomyces bottropensis.
PURITY:	≥98%
APPEARANCE:	Off-white to greenish solid.
SOLUBILITY:	Soluble in DMSO; fairly soluble in methanol; poorly soluble in acetone.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Pyridone metabolite. Inhibitor of nitric oxide synthases (NOS) showing selectivity for eNOS (NOS III) versus nNOS (NOS I). Inhibitor of thaxtomine biosynthesis and of mitochondrial electron transport chain.

Product Specific Literature References

The iromycins, a new family of pyridone metabolites from Streptomyces sp. I. Structure, NOS inhibitory activity, and biosynthesis: F. Surup, et al; J. Org. Chem. 72, 5085 (2007) Abstract
Iromycins: a new family of pyridone metabolites from Streptomyces sp. II. Convergent total synthesis: H. Shojaei, et al.; J. Org. Chem. 72, 5091 (2007) Abstract
Iromycins from Streptomyces sp. and from synthesis: New inhibitors of the mitochondrial electron transport chain: F. Surup, et al.; Bioorg. Med. Chem. 16, 1738 (2008) Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity)

header picture © micronaut.ch, another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.