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ALX-380-229 Revised 14-Jan-08
Isoapoptolidin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-229-MC01   0.1 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C58H96O21
MW: 1129.4
CAS NUMBER: 476647-30-0
SOURCE/HOST: Isolated from Amycolatopsis sp. MST-AS5912.
PURITY: ≥90% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Isomer of apoptolidin (Prod. No. ALX-380-207). In water an equilibrium mixture of apoptolidin:isoapoptolidin (~1.5:1) is formed within hours. Less active F0F1-ATPase inhibitor (IC50=17µM) than apoptolidin (IC50=0.7µM).
Product Specific Literature References
Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of apoptolidin: J.D. Pennington, et al.; Org. Lett. 4, 3823 (2002) Abstract
Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin: P.A. Wender, et al.; Org. Lett. 4, 3819 (2002) Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products
 
 
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