ALEXIS Biochemicals: Isotetrandrine

ALX-350-035

Revised 14-Nov-07

Isotetrandrine
SYNONYMS	Berbamine methyl ether
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-035-M001		1 mg	65.00 USD

Product Specification

FORMULA:	C₃₈H₄₂N₂O₆
MW:	622.8
CAS NUMBER:	477-57-6
RTECS:	NX7285000
PURITY:	≥98%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Alkaloid inhibitor of G-protein mediated activation of phospholipase A₂(PLA₂) but not phospholipase C or D.

Product Specific Literature References

Total syntheses of optically active natural isotetrandrine, phaeanthine and tetrandrine
: Y. Inubushi, et al.; Tetrahedron Lett. 30, 3399 (1968) Abstract
Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets: T. Hashizume, et al.; Biochem. Pharmacol. 41, 419 (1991) Abstract
Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells: S. Akiba, et al.; Biochem. Pharmacol. 44, 45 (1992) Abstract
Inhibition of membrane tubule formation and trafficking by isotetrandrine, an antagonist of G-protein-regulated phospholipase A2 enzymes: D. Chan, et al.; Mol. Biol. Cell 15, 1871 (2004) Abstract

Further Categories Containing This Product:

PLA2 Inhibitors • Alkaloids

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