ALEXIS Biochemicals: JYL-273

ALX-550-390

Revised 28-Jun-07

JYL-273
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	TRPV1 Agonists and Antagonists / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-390-M001		1 mg	70.00 USD
ALX-550-390-M005		5 mg	280.00 USD

Product Specification

FORMULA:	C₂₈H₄₀N₂O₄S
MW:	500.7
CAS NUMBER:	289902-71-2
PURITY:	≥98%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in methanol, 100% ethanol, DMSO or other organic solvents; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent TRPV1 agonist (K_i=11nM). About 500-fold more potent than capsaicin (Prod. No. ALX-550-066). RTX binding affinity (K_i=6.35nM), agonism (calcium influx; EC₅₀=2.83nM).

Product Specific Literature References

N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 9, 19 (2001) Abstract
Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics: J. Lee, et al.; Bioorg. Med. Chem. 10, 1171 (2002) Abstract

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