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ALX-430-127 Revised 20-Feb-07
KN-93 (water soluble)
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SYNONYMS KN-93 . hydrogen phosphate
2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine . hydrogen phosphate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-127-M001   1 mg 90.00 USD Add To Cart
ALX-430-127-M005   5 mg 315.00 USD Add To Cart
Product Specification
FORMULA: C26H29ClN2O4S . H3PO4
MW: 501.0 . 98.0
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light. Hygroscopic.
HAZARD: IRRITANT.

Product Description
Selective inhibitor of rat brain Ca2+/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A (PKA) activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
Product Specific Literature References
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991) Abstract
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993) Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993) Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Obesity & Diabetes Other Products
 
 
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