ALEXIS Biochemicals: Kahalalide F - Discontinued Due to Patent Restrictions

ALX-350-292

Revised 26-Mar-05

Kahalalide F - Discontinued Due to Patent Restrictions
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-292-C500		500 µg

Product Specification

FORMULA:	C₇₅H₁₂₄N₁₄O₁₆
MW:	1477.9
CAS NUMBER:	149204-42-2
SOURCE/HOST:	Isolated from marine mollusc Elysia rufescens.
PURITY:	≥95%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Highly selective activity against prostate tumors in vitro. Disrupts lysosomal membranes. Inhibitor of c-erbB-2 (ErbB2).

Product Specific Literature References

The antitumoral compound Kahalalide F acts on cell lysosomes: M. Garcia-Rocha, et al.; Cancer Lett. 99, 43 (1996) Abstract
Synthesis and structure determination of kahalalide F (1,2): Synthesis and structure determination of kahalalide F (1,2); J. Am. Chem. Soc. 123, 11398 (2001) Abstract
Chemical and enzymatic stability of a cyclic depsipeptide, the novel, marine-derived, anti-cancer agent kahalalide F: R.W. Sparidans, et al.; Anticancer Drugs 12, 575 (2001) Abstract
Preclinical toxicity studies of kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat: A.P. Brown, et al.; Cancer Chemother. Pharmacol. 50, 333 (2002) Abstract
Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry: E. Stokvis, et al.; J. Mass. Spectrom. 37, 992 (2002) Abstract

Further Categories Containing This Product:

Tyrosine Kinase Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Protein Kinase Inhibitors • erbB-2 / Related Products

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