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ALX-630-085 Revised 07-Apr-08
Kaliotoxin
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SYNONYMS KTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-085-C010   10 µg 190.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Val-Glu-Ile-Asn-Val-Lys-Cys-Ser-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-Lys-OH
(Disulfide bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35)
FORMULA: C171H283N55O49S8
MW: 4150.0
CAS NUMBER: 145199-73-1
SOURCE/HOST: Synthetic. Originally isolated from Androctonus mauretanicus mauretanicus scorpion venom.
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description

High conductance Ca2+-activated K+ channel blocker. Highly selective for Kv1.1 and Kv1.3. Blocking of Kv1.3 inhibits T cell activation.
Product Specific Literature References
Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)- activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom: M. Crest, et al.; J. Biol. Chem. 267, 1640 (1992) Abstract; Full Text
Synthesis and characterization of kaliotoxin. Is the 26-32 sequence essential for potassium channel recognition?: R. Romi, et al.; J. Biol. Chem. 268, 26302 (1993) Abstract; Full Text
3D structure of kaliotoxin: is residue 34 a key for channel selectivity?: M. Gairi, et al.; J. Pept. Sci. 3, 314 (1997) Abstract
Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits: C. Mourre, et al.; J. Pharmacol. Exp. Ther. 291, 943 (1999) Abstract
Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation: C. Beeton, et al.; J. Immunol. 166, 936 (2001) Abstract
Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation: C. Beeton, et al.; J. Immunol. 19, 936 (2001), 155 Abstract
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR: A. Lange, et al.; Nature 440, 959 (2006) Abstract
Further Categories Containing This Product:
K+ Channel Blockers & Inhibitors
 
 
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