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ALX-630-041 Revised 19-May-08
Kaliotoxin (1-37)
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SYNONYMS KTx (1-37)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-041-C100   100 µg 550.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Val-Glu-Ile-Asn-Val-Lys-Cys-Ser-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-OH
(Disulfide bonds between Cys8-Cys28, Cys 14-Cys33 and Cys18-Cys35)
FORMULA: C165H271N53O48S8
MW: 4021.8
SOURCE/HOST: Synthetic. Originally isolated from Androctonus mauretanicus mauretanicus.
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
High conductance Ca2+-activated K+ channel blocker.
Product Specific Literature References
Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)- activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom: M. Crest, et al.; J. Biol. Chem. 267, 1640 (1992) Abstract; Full Text
Synthesis and characterization of kaliotoxin. Is the 26-32 sequence essential for potassium channel recognition?: R. Romi, et al.; J. Biol. Chem. 268, 26302 (1993) Abstract; Full Text
Kaliotoxin (1-37) shows structural differences with related potassium channel blockers: I. Fernandez, et al.; Biochemistry 33, 14256 (1994) Abstract
3D structure of kaliotoxin: is residue 34 a key for channel selectivity?: M. Gairi, et al.; J. Pept. Sci. 3, 314 (1997) Abstract
On the kaliotoxin and dendrotoxin binding sites on rat brain synaptosomes: N. Tricaud, et al.; Toxicon 38, 1749 (2000) Abstract
Heterogeneous competition of Kv1 channel toxins with kaliotoxin for binding in rat brain: autoradiographic analysis: R. Bessone, et al.; Neurochem. Int. 45, 1039 (2004) Abstract
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR: A. Lange, et al.; Nature 440, 959 (2006) Abstract
Further Categories Containing This Product:
K+ Channel Blockers & Inhibitors
 
 
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