ALEXIS Biochemicals: Kazusamycin A

ALX-380-230

Revised 07-Apr-08

Kazusamycin A
SYNONYMS	Kazusamycin Hydroxyleptomycin B Antibiotic CL 1957B Hydroxyelactocin PD 114,721
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-230-MC01		0.1 mg	460.00 USD

Product Specification

FORMULA:	C₃₃H₄₈O₇
MW:	556.7
CAS NUMBER:	92090-94-3
RTECS:	OA0550000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS4898.
PURITY:	≥95% (HPLC)
APPEARANCE:	Colorless film.
SOLUBILITY:	Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Shows potent antitumor activity in vitro and in vivo against several tumor cell lines. Has antibacterial and antifungal activities. Inhibitor of nuclear export.

Product Specific Literature References

A new antitumor antibiotic, kazusamycin: I. Umezawa, et al.; J. Antibiot. (Tokyo) 37, 706 (1984) Abstract
Antitumor activity of a new antibiotic, kazusamycin: K. Komiyama, et al.; J. Antibiot. (Tokyo) 38, 224 (1985) Abstract
Novel antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721. Taxonomy, fermentation and biological activity: J.B. Tunac, et al.; J. Antibiot. (Tokyo) 38, 460 (1985) Abstract
In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721): B.J. Roberts, et al.; Cancer Chemother. Pharmacol. 16, 95 (1986) Abstract
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA: B. Wolff, et al.; Chem. Biol. 4, 139 (1997) Abstract; Full Text

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