ALEXIS Biochemicals: Kazusamycin B

ALX-380-231

Revised 14-Mar-08

Kazusamycin B
SYNONYMS	Hydroxyleptomycin A Antibiotic CL 1957E PD 124,895
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-231-MC01		0.1 mg	460.00 USD

Product Specification

FORMULA:	C₃₂H₄₆O₇
MW:	542.7
CAS NUMBER:	107140-30-7
RTECS:	OA0551000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS4898.
PURITY:	≥95% (HPLC)
APPEARANCE:	Colorless film.
SOLUBILITY:	Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Shows potent antitumor activity in vitro and in vivo against several tumor cell lines, including L1210 and P388 leukemia cells. Has antibacterial and antifungal activities. Inhibitor of nuclear export.

Product Specific Literature References

PD 124,895 and PD 124,966, two new antitumor antibiotics: T.R. Hurley, et al.; J. Antibiot. (Tokyo) 39, 1651 (1986) Abstract
Kazusamycin B, a novel antitumor antibiotic: K. Funaishi, et al.; J. Antibiot. (Tokyo) 40, 778 (1987) Abstract
Antitumor effect of kazusamycin B on experimental tumors: E. Yoshida, et al.; J. Antibiot. (Tokyo) 40, 1596 (1987) Abstract
The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells: K. Takamiya, et al.; J. Antibiot. (Tokyo) 41, 1854 (1988) Abstract
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA: B. Wolff, et al.; Chem. Biol. 4, 139 (1997) Abstract; Full Text

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