ALEXIS Biochemicals: L-AP3

ALX-550-038

Revised 17-Jan-05

L-AP3
SYNONYMS	L(+)-2-Amino-3-phosphonopropanoic acid
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Glutamate Receptors (Metabotropic) / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-038-M005		5 mg	55.00 USD
ALX-550-038-M025		25 mg	220.00 USD

Product Specification

FORMULA:	C₃H₈NO₅P
MW:	169.1
CAS NUMBER:	23052-80-4
PURITY:	≥97%
APPEARANCE:	White hygroscopic solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Selective antagonist of the PI-linked metabotropic glutamate response.

Product Specific Literature References

1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons: A.J. Irving, et al.; Eur. J. Pharmacol. 186, 363 (1990) Abstract
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid: D.D. Schoepp, et al.; Mol. Pharmacol. 38, 222 (1990) Abstract
Metabotropic glutamate receptors in brain function and pathology: D.D. Schoepp & P.J. Conn; TIPS 14, 13 (1993), (Review) Abstract
Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation: J.J. O'Connor, et al.; Nature 367, 557 (1994) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract

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