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ALX-550-026 Revised 27-Nov-04
L-AP4
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SYNONYMS L(+)-2-Amino-4-phosphonobutanoic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-026-M005   5 mg 65.00 USD Add To Cart
ALX-550-026-M025   25 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C4H10NO5P
MW: 183.1
CAS NUMBER: 23052-81-5
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Selective agonist for group III mGluRs.
Product Specific Literature References
Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex: J.F. Koerner & C.W. Cotman; Brain Res. 216, 192 (1981) Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord: J. Davies & J.C. Watkins; Brain Res. 235, 378 (1982) Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982) Abstract
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists: J.C. Watkins, et al.; TIPS 11, 25 (1990) Abstract
L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase: C. Thomsen, et al.; Eur. J. Pharmacol. 227, 361 (1992) Abstract
L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor: P.Q. Trombley and G.L. Westbrook; J. Neurosci. 12, 2043 (1992) Abstract
Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate: Y. Nakajima, et al.; J. Biol. Chem. 268, 11868 (1993) Abstract; Full Text
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
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