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ALX-550-083 Revised 28-Jan-05
L-CCG-IV
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SYNONYMS (2S,1'R,2S)-2-(Carboxycyclopropyl)glycine
(2S,3R,4S)-CCG
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-083-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C6H9NO4
MW: 159.1
CAS NUMBER: 117857-95-1
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Potent NMDA receptor agonist.
Product Specific Literature References
Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord: Shinozaki, et al.; Br. J. Pharmacol. 98, 1213 (1989) Abstract
A significant increase in intracellular Ca2+ concentration induced by (2S,3R,4S)-2-(carboxycyclopropyl)glycine, a new potent NMDA agonist, in cultured rat hippocampal neurons: Y. Kudo, et al.; Brain Res. 567, 342 (1991) Abstract
Synthesis of Four Diastereomeric L-2-(Carboxycyclopropyl)glycines. Conformationally Constrained L-Glutamate Analogues: K. Shimamoto, et al.; J. Org. Chem. 56, 4167 (1991)
Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells: Y. Hayashi, et al.; Br. J. Pharmacol. 107, 539 (1992) Abstract
2-(Carboxycyclopropyl)glycines: binding, neurotoxicity and induction of intracellular free Ca2+ increase: M. Kawai, et al.; Eur. J. Pharmacol. 211, 195 (1992) Abstract
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins & G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
NMDA receptor heterogeneity in mammalian tissues: focus on two agonists, (2S,3R,4S) cyclopropylglutamate and the sulfate ester of 4-hydroxy-(S)-pipecolic acid: F. Moroni, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 351, 371 (1995) Abstract
Inhibition by folded isomers of L-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-1: H. Yamashita, et al.; Eur. J. Pharmacol. 289, 387 (1995) Abstract
Syntheses and conformational analyses of glutamate analogs: 2-(2- carboxy-3-substituted-cyclopropyl)glycines as useful probes for excitatory amino acid receptors: K. Shimamoto & Y. Ohfune; J. Med. Chem. 39, 407 (1996), (Review) Abstract
 
 

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