ALEXIS Biochemicals: LBP (human) (recombinant) (His)

ALX-201-131

Revised 15-May-07

LBP (human) (recombinant) (His)
SYNONYMS	Lipopolysaccharide Binding Protein (human) (recombinant) (His)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Lipopolysaccharide Binding Protein [LBP]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-131-C010		10 µg	295.00 USD

Product Specification

SOURCE/HOST:	Produced in CHO cells.
CONCENTRATION:	0.25mg/ml after reconstitution.
PURITY:	~90-95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS, pH 7.2.
ENDOTOXIN CONTENT:	<0.00015EU/µg protein (LAL test; Chromogenix).
RECONSTITUTION:	Reconstitute with 40µl distilled water.
BIOLOGICAL ACTIVITY:	Mediates binding of LPS to CD14 (up to 0.2µg/ml LBP mediates binding of FITC-LPS (0.5µg/ml) to CD14⁺ CHO transfectants (FACS)).
SHIPPING:	SHIPPED ON DRY ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Will precipitate by rapid changes of pH or temperature. Best working temperature is ice bath.
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism: U. Grunwald, et al.; J. Immunol. 157, 4119 (1996) Abstract

General Information

LBP (lipopolysaccharide binding protein) is a ~58kDa acute phase glycoprotein and binds to the lipid A portion of lipopolysaccharide (LPS) with high affinity and catalyzes the CD14 dependent cellular activation by LPS.
BACKGROUND/TECHNICAL INFORMATION	Note: His-tag at the C-terminal end of the LBP has no protease site and cannot be split off.
MANUFACTURER	Manufactured by Biometec.

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