ALEXIS Biochemicals: LBP (mouse) (recombinant) (His)

ALX-201-132

Revised 28-Jul-06

LBP (mouse) (recombinant) (His)
SYNONYMS	Lipopolysaccharide Binding Protein (mouse) (recombinant) (His)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Lipopolysaccharide Binding Protein [LBP]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-132-C010		10 µg	295.00 USD

Product Specification

MW:	~58kDa.
SOURCE/HOST:	Produced in CHO cells.
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	Affinity purified
FORMULATION:	Lyophilized. Contains PBS, pH 7.2.
ENDOTOXIN CONTENT:	<0.00015EU/µg protein (LAL test; Chromogenix).
RECONSTITUTION:	Reconstitute with 10µl distilled water.
BIOLOGICAL ACTIVITY:	Mediates binding of LPS to CD14 (up to 2µg/ml LBP mediates binding of FITC-LPS (0.5µg/ml) to CD14⁺ CHO transfectants (2x10⁶/ml)).
SHIPPING:	SHIPPED ON DRY ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-80°C
USE/STABILITY:	LBP will precipitate upon rapid changes of pH or temperature. Keep in ice bath during application.
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism: U. Grunwald, et al.; J. Immunol. 157, 4119 (1996) Abstract

General Information

LBP (lipopolysaccharide binding protein) is a 58kDa acute phase glycoprotein and binds to the lipid A portion of lipopolysaccharide (LPS) with high affinity and catalyzes the CD14 dependent cellular activation by LPS.
BACKGROUND/TECHNICAL INFORMATION	His-tag at C-terminal end of LBP has no protease site and cannot be split off.
MANUFACTURER	Manufactured by Biometec.

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